Setting description

TC3 and TC4 more effective in the HRD+ biomarker signature

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4 TC5
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.112, shape = 1.05
all summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 9.9, median = 7.1 mean = 9.9, median = 7.1 mean = 8.8, median = 6.3
all effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.13, hr = 0.88 af = 1.13, hr = 0.88 af = 1, hr = 1
AR- & TP53- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.096, shape = 1.05 scale = 0.096, shape = 1.05 scale = 0.112, shape = 1.05
AR- & TP53- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 10.2, median = 7.4 mean = 10.2, median = 7.4 mean = 8.8, median = 6.3
AR- & TP53- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.16, hr = 0.85 af = 1.16, hr = 0.85 af = 1, hr = 1
HRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
HRD+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
HRD+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.107, shape = 1.05 scale = 0.107, shape = 1.05 scale = 0.112, shape = 1.05
TP53+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 9.2, median = 6.6 mean = 9.2, median = 6.6 mean = 8.8, median = 6.3
TP53+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.04, hr = 0.96 af = 1.04, hr = 0.96 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.097, shape = 1.05 scale = 0.097, shape = 1.05 scale = 0.112, shape = 1.05
TEfus+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 10.1, median = 7.3 mean = 10.1, median = 7.3 mean = 8.8, median = 6.3
TEfus+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.15, hr = 0.87 af = 1.15, hr = 0.87 af = 1, hr = 1
PI3K+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.104, shape = 1.05 scale = 0.104, shape = 1.05 scale = 0.112, shape = 1.05
PI3K+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 9.4, median = 6.8 mean = 9.4, median = 6.8 mean = 8.8, median = 6.3
PI3K+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.07, hr = 0.93 af = 1.07, hr = 0.93 af = 1, hr = 1



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4 TC5
—– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-+— summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-+— effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
-+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-+–+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-+–+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
-+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-+-+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-+-+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
-+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-+-++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-+-++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
-++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-++– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-++– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
-++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-++-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
-+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-+++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-+++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
-++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-++++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
+—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+–+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+–+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+–++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+–++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
++— summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
++— effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
++–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
++–+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
++–+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
++-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
++-+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
++-+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
++-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
++-++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
++-++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
+++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
+++– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
+++– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
+++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
+++-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
+++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
++++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
++++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
++++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
+++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
+++++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
+++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 6 1 14 15 3
AR- & TP53- 20 24 39 50 13
HRD+ 0 1 275 281 0
TP53+ 5 2 7 8 3
TEfus+ 2 2 6 9 2
PI3K+ 5 5 9 12 2
TC1 TC2 TC3 TC4 TC5
all 0.012 0.002 0.028 0.030 0.006
AR- & TP53- 0.040 0.048 0.078 0.100 0.026
HRD+ 0.000 0.002 0.550 0.562 0.000
TP53+ 0.010 0.004 0.014 0.016 0.006
TEfus+ 0.004 0.004 0.012 0.018 0.004
PI3K+ 0.010 0.010 0.018 0.024 0.004
futility (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 7 3 0 0 4
AR- & TP53- 131 103 1 2 101
HRD+ 26 31 0 0 34
TP53+ 40 41 13 21 38
TEfus+ 16 18 1 1 15
PI3K+ 28 30 8 9 40
TC1 TC2 TC3 TC4 TC5
all 0.014 0.006 0.000 0.000 0.008
AR- & TP53- 0.262 0.206 0.002 0.004 0.202
HRD+ 0.052 0.062 0.000 0.000 0.068
TP53+ 0.080 0.082 0.026 0.042 0.076
TEfus+ 0.032 0.036 0.002 0.002 0.030
PI3K+ 0.056 0.060 0.016 0.018 0.080
max sample size (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 0 0 0 0 0
AR- & TP53- 53 31 41 46 44
HRD+ 0 0 0 0 0
TP53+ 0 0 0 0 0
TEfus+ 0 0 0 0 0
PI3K+ 0 0 0 0 0
TC1 TC2 TC3 TC4 TC5
all 0.000 0.000 0.000 0.000 0.000
AR- & TP53- 0.106 0.062 0.082 0.092 0.088
HRD+ 0.000 0.000 0.000 0.000 0.000
TP53+ 0.000 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000 0.000 0.000
PI3K+ 0.000 0.000 0.000 0.000 0.000


Operating characteristics

char overall TC1 TC2 TC3 TC4 TC5
err_sign 0.3286573 0.0761523 0.0641283 0.0821643 0.1022044 0.0420842
err_type 0.4228457 0.0761523 0.0641283 0.1382766 0.1663327 0.0420842
pow_sign 0.8036072 0.0000000 0.0000000 0.5511022 0.5631263 0.0000000
pow_type 0.8737475 0.0000000 0.0000000 0.6332665 0.6653307 0.0000000

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4 TC5
all graduation 0 6 1 14 15 3
all futility 0 7 3 0 0 4
all max_n 0 0 0 0 0 0
all n 366 (335, 406) 160 (100, 225) 160 (108, 219) 163 (112, 217) 159 (110, 217) 165 (105, 224)
all n_unique 335 (306, 373) 148 (92, 210) 146 (98, 202) 150 (103, 200) 146 (99, 201) 152 (96, 208)
all time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
all time_stop NA (NA, NA) 5 (3, 7) 4 (3, 5) 7 (6, 9) 8 (6, 13) 10 (7, 11)
all post_p NA (NA, NA) 0.45 (0.07, 0.87) 0.46 (0.09, 0.86) 1 (0.91, 1) 1 (0.92, 1) 0.47 (0.07, 0.87)
all rate 0.112 (0.104, 0.12) 0.113 (0.1, 0.129) 0.113 (0.102, 0.127) 0.084 (0.073, 0.095) 0.084 (0.072, 0.095) 0.113 (0.102, 0.128)
AR- & TP53- graduation 0 20 24 39 50 13
AR- & TP53- futility 0 131 103 1 2 101
AR- & TP53- max_n 0 53 31 41 46 44
AR- & TP53- n 217 (191, 251) 87 (29, 150) 77 (31, 139) 89 (47, 143) 88 (45, 146) 85 (33, 146)
AR- & TP53- n_unique 201 (175, 232) 80 (28, 140) 71 (29, 129) 82 (43, 135) 81 (39, 137) 79 (30, 138)
AR- & TP53- time_trial 36 (36, 36) 36 (10, 36) 36 (14, 36) 36 (36, 36) 36 (32, 36) 36 (16, 36)
AR- & TP53- time_stop NA (NA, NA) 12 (6, 28) 17 (10, 31) 14 (9, 25) 14 (10, 27) 19 (11, 33)
AR- & TP53- post_p NA (NA, NA) 0.41 (0.07, 0.85) 0.4 (0.08, 0.87) 1 (0.88, 1) 0.99 (0.87, 1) 0.44 (0.08, 0.87)
AR- & TP53- rate 0.113 (0.102, 0.123) 0.115 (0.098, 0.14) 0.114 (0.098, 0.14) 0.076 (0.06, 0.093) 0.077 (0.058, 0.093) 0.114 (0.098, 0.14)
HRD+ graduation 0 0 1 275 281 0
HRD+ futility 0 26 31 0 0 34
HRD+ max_n 0 0 0 0 0 0
HRD+ n 60 (48, 72) 21 (10, 35) 23 (13, 35) 34 (25, 56) 32 (25, 54) 22 (14, 35)
HRD+ n_unique 55 (44, 67) 19 (10, 32) 20 (11, 32) 31 (22, 51) 29 (21, 49) 20 (12, 32)
HRD+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 33 (19, 36) 32 (19, 36) 36 (36, 36)
HRD+ time_stop NA (NA, NA) 32 (28, 35) 34 (26, 36) 23 (17, 33) 24 (17, 32) 32 (25, 36)
HRD+ post_p NA (NA, NA) 0.31 (0.08, 0.75) 0.32 (0.07, 0.73) 1 (1, 1) 1 (1, 1) 0.32 (0.06, 0.73)
HRD+ rate 0.114 (0.093, 0.137) 0.114 (0.082, 0.165) 0.116 (0.085, 0.156) 0.036 (0.025, 0.047) 0.035 (0.025, 0.047) 0.114 (0.086, 0.161)
TP53+ graduation 0 5 2 7 8 3
TP53+ futility 0 40 41 13 21 38
TP53+ max_n 0 0 0 0 0 0
TP53+ n 122 (106, 139) 58 (34, 79) 63 (41, 82) 56 (35, 77) 55 (34, 75) 61 (37, 81)
TP53+ n_unique 110 (96, 126) 53 (31, 72) 57 (37, 75) 51 (31, 70) 50 (30, 69) 56 (34, 75)
TP53+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
TP53+ time_stop NA (NA, NA) 20 (15, 33) 20 (14, 30) 20 (15, 29) 22 (17, 30) 23 (12, 31)
TP53+ post_p NA (NA, NA) 0.46 (0.08, 0.87) 0.48 (0.12, 0.86) 0.64 (0.21, 0.95) 0.68 (0.19, 0.97) 0.46 (0.09, 0.83)
TP53+ rate 0.111 (0.097, 0.128) 0.115 (0.093, 0.141) 0.113 (0.095, 0.138) 0.104 (0.083, 0.128) 0.103 (0.084, 0.13) 0.114 (0.095, 0.14)
TEfus+ graduation 0 2 2 6 9 2
TEfus+ futility 0 16 18 1 1 15
TEfus+ max_n 0 0 0 0 0 0
TEfus+ n 115 (99, 133) 54 (35, 73) 58 (41, 79) 56 (39, 74) 56 (38, 73) 58 (38, 76)
TEfus+ n_unique 104 (89, 119) 48 (31, 66) 52 (37, 72) 52 (34, 67) 51 (33, 66) 53 (35, 69)
TEfus+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
TEfus+ time_stop NA (NA, NA) 20 (16, 32) 16 (15, 26) 12 (11, 19) 18 (14, 20) 18 (12, 28)
TEfus+ post_p NA (NA, NA) 0.46 (0.08, 0.85) 0.42 (0.1, 0.87) 0.93 (0.61, 1) 0.93 (0.55, 1) 0.41 (0.1, 0.86)
TEfus+ rate 0.112 (0.098, 0.129) 0.113 (0.093, 0.145) 0.114 (0.096, 0.137) 0.083 (0.067, 0.105) 0.083 (0.065, 0.105) 0.114 (0.095, 0.139)
PI3K+ graduation 0 5 5 9 12 2
PI3K+ futility 0 28 30 8 9 40
PI3K+ max_n 0 0 0 0 0 0
PI3K+ n 121 (104, 136) 54 (32, 79) 56 (35, 78) 54 (34, 75) 53 (33, 75) 64 (42, 88)
PI3K+ n_unique 109 (95, 124) 49 (29, 71) 50 (31, 72) 49 (30, 68) 48 (30, 68) 59 (39, 80)
PI3K+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
PI3K+ time_stop NA (NA, NA) 24 (15, 31) 19 (15, 30) 17 (15, 24) 21 (14, 31) 19 (9, 30)
PI3K+ post_p NA (NA, NA) 0.47 (0.11, 0.88) 0.48 (0.1, 0.84) 0.77 (0.37, 0.98) 0.76 (0.33, 0.98) 0.48 (0.1, 0.86)
PI3K+ rate 0.113 (0.099, 0.128) 0.113 (0.092, 0.141) 0.113 (0.095, 0.143) 0.098 (0.077, 0.119) 0.097 (0.078, 0.123) 0.114 (0.097, 0.138)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4 TC5
—– graduation 0 26 25 52 63 16
—– futility 0 134 106 1 2 102
—– max_n 0 53 31 41 46 44
—– n 125 (104, 150) 45 (18, 103) 36 (12, 95) 36 (11, 86) 38 (10, 94) 39 (11, 98)
—– n_unique 116 (95, 140) 43 (18, 99) 35 (12, 91) 34 (10, 83) 37 (10, 89) 37 (10, 93)
—– post_p NA (NA, NA) 0.45 (0.12, 0.86) 0.41 (0.1, 0.87) 0.42 (0.08, 0.88) 0.44 (0.1, 0.89) 0.43 (0.09, 0.89)
—– rate 0.113 (0.1, 0.127) 0.116 (0.097, 0.156) 0.117 (0.096, 0.175) 0.119 (0.093, 0.174) 0.116 (0.094, 0.176) 0.117 (0.094, 0.172)
—-+ graduation 0 31 29 60 71 17
—-+ futility 0 146 120 9 11 126
—-+ max_n 0 53 31 41 46 44
—-+ n 30 (22, 39) 10 (3, 26) 10 (3, 25) 10 (3, 23) 10 (3, 23) 13 (5, 28)
—-+ n_unique 27 (20, 36) 9 (3, 24) 9 (2, 23) 9 (2, 21) 9 (3, 21) 12 (4, 26)
—-+ post_p NA (NA, NA) 0.47 (0.16, 0.85) 0.44 (0.16, 0.84) 0.46 (0.16, 0.84) 0.46 (0.17, 0.84) 0.47 (0.19, 0.86)
—-+ rate 0.114 (0.089, 0.149) 0.123 (0.081, 0.282) 0.125 (0.08, 0.268) 0.122 (0.081, 0.269) 0.121 (0.08, 0.287) 0.12 (0.082, 0.218)
—+- graduation 0 27 27 55 69 17
—+- futility 0 141 113 2 3 111
—+- max_n 0 53 31 41 46 44
—+- n 5 (2, 8) 3 (0, 6) 2 (0, 6) 3 (0, 6) 2 (0, 5) 2 (0, 5)
—+- n_unique 4 (2, 7) 2 (0, 5) 2 (0, 5) 2 (0, 5) 2 (0, 5) 2 (0, 5)
—+- post_p NA (NA, NA) 0.45 (0.28, 0.72) 0.47 (0.29, 0.75) 0.5 (0.28, 0.74) 0.48 (0.29, 0.74) 0.46 (0.29, 0.76)
—+- rate 0.114 (0.057, 0.253) 0.135 (0.054, 0.455) 0.134 (0.051, 0.422) 0.127 (0.041, 0.432) 0.128 (0.041, 0.521) 0.14 (0.052, 0.6)
—++ graduation 0 32 31 63 77 18
—++ futility 0 153 126 10 11 131
—++ max_n 0 53 31 41 46 44
—++ n 13 (8, 19) 5 (1, 13) 5 (1, 11) 5 (1, 11) 5 (2, 11) 6 (2, 14)
—++ n_unique 12 (8, 17) 5 (1, 12) 4 (1, 10) 4 (1, 10) 4 (1, 10) 6 (2, 13)
—++ post_p NA (NA, NA) 0.44 (0.21, 0.81) 0.47 (0.23, 0.81) 0.43 (0.19, 0.8) 0.46 (0.22, 0.8) 0.46 (0.2, 0.82)
—++ rate 0.113 (0.076, 0.172) 0.13 (0.069, 0.384) 0.128 (0.068, 0.34) 0.136 (0.069, 0.436) 0.13 (0.071, 0.354) 0.124 (0.074, 0.306)
–+– graduation 0 11 3 21 23 6
–+– futility 0 47 44 13 21 42
–+– max_n 0 0 0 0 0 0
–+– n 26 (19, 33) 11 (5, 25) 11 (4, 24) 9 (3, 22) 9 (3, 21) 10 (3, 23)
–+– n_unique 23 (17, 31) 10 (4, 22) 10 (3, 22) 8 (3, 20) 8 (3, 20) 9 (3, 21)
–+– post_p NA (NA, NA) 0.42 (0.15, 0.85) 0.47 (0.16, 0.84) 0.4 (0.16, 0.82) 0.44 (0.17, 0.82) 0.44 (0.16, 0.84)
–+– rate 0.11 (0.082, 0.152) 0.123 (0.084, 0.242) 0.12 (0.078, 0.274) 0.128 (0.081, 0.259) 0.125 (0.078, 0.251) 0.127 (0.079, 0.284)
–+-+ graduation 0 16 6 29 35 7
–+-+ futility 0 71 68 21 25 64
–+-+ max_n 0 0 0 0 0 0
–+-+ n 25 (18, 32) 10 (3, 21) 10 (3, 22) 9 (3, 21) 8 (3, 19) 12 (4, 24)
–+-+ n_unique 23 (16, 30) 9 (3, 19) 9 (3, 19) 8 (3, 20) 8 (3, 17) 11 (4, 22)
–+-+ post_p NA (NA, NA) 0.46 (0.18, 0.86) 0.49 (0.16, 0.86) 0.42 (0.16, 0.84) 0.44 (0.17, 0.81) 0.46 (0.15, 0.85)
–+-+ rate 0.115 (0.085, 0.15) 0.122 (0.079, 0.268) 0.122 (0.078, 0.291) 0.129 (0.08, 0.258) 0.127 (0.082, 0.256) 0.123 (0.083, 0.23)
–++- graduation 0 13 5 26 30 7
–++- futility 0 59 58 14 21 49
–++- max_n 0 0 0 0 0 0
–++- n 7 (3, 11) 3 (1, 7) 4 (1, 8) 3 (1, 7) 3 (1, 7) 3 (1, 7)
–++- n_unique 6 (3, 10) 3 (1, 6) 4 (1, 8) 3 (1, 6) 3 (1, 6) 3 (1, 6)
–++- post_p NA (NA, NA) 0.48 (0.26, 0.78) 0.44 (0.24, 0.75) 0.48 (0.29, 0.78) 0.48 (0.27, 0.76) 0.46 (0.25, 0.77)
–++- rate 0.113 (0.064, 0.217) 0.125 (0.058, 0.463) 0.129 (0.064, 0.365) 0.12 (0.052, 0.414) 0.127 (0.052, 0.459) 0.136 (0.053, 0.546)
–+++ graduation 0 18 8 34 42 8
–+++ futility 0 79 78 22 25 71
–+++ max_n 0 0 0 0 0 0
–+++ n 19 (14, 26) 8 (3, 16) 8 (3, 18) 7 (2, 17) 7 (2, 16) 9 (4, 19)
–+++ n_unique 17 (12, 24) 7 (2, 15) 7 (3, 16) 6 (2, 15) 6 (2, 15) 9 (4, 17)
–+++ post_p NA (NA, NA) 0.46 (0.19, 0.83) 0.46 (0.19, 0.86) 0.42 (0.18, 0.81) 0.44 (0.17, 0.8) 0.44 (0.18, 0.79)
–+++ rate 0.111 (0.077, 0.159) 0.124 (0.075, 0.299) 0.123 (0.078, 0.28) 0.13 (0.076, 0.315) 0.126 (0.076, 0.296) 0.125 (0.082, 0.244)
-+— graduation 0 26 26 290 308 16
-+— futility 0 154 133 1 2 131
-+— max_n 0 52 30 38 42 43
-+— n 27 (19, 35) 5 (1, 16) 7 (2, 15) 15 (8, 28) 14 (7, 27) 6 (2, 15)
-+— n_unique 25 (17, 33) 5 (1, 14) 6 (2, 14) 14 (7, 26) 12 (6, 25) 6 (2, 13)
-+— post_p NA (NA, NA) 0.34 (0.15, 0.66) 0.33 (0.14, 0.64) 0.99 (0.86, 1) 0.98 (0.81, 1) 0.32 (0.14, 0.64)
-+— rate 0.112 (0.084, 0.155) 0.125 (0.076, 0.36) 0.124 (0.076, 0.261) 0.036 (0.022, 0.055) 0.035 (0.021, 0.058) 0.126 (0.075, 0.3)
-+–+ graduation 0 30 30 294 308 17
-+–+ futility 0 165 143 9 10 154
-+–+ max_n 0 52 30 38 42 43
-+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.53 (0.5, 0.53) 0.56 (0.56, 0.56) 0.49 (0.49, 0.49)
-+–+ rate 0.169 (0, 1.358) 0.111 (0, 0.405) 0.115 (0.017, 0.468) 0 (0, 0.307) 0.019 (0, 0.713) 0.183 (0.029, 9.55)
-+-+- graduation 0 27 28 290 308 17
-+-+- futility 0 161 138 1 3 140
-+-+- max_n 0 52 30 38 42 43
-+-+- n 12 (8, 18) 4 (0, 9) 4 (1, 9) 7 (3, 13) 7 (2, 13) 4 (2, 9)
-+-+- n_unique 11 (7, 16) 3 (0, 8) 4 (1, 8) 6 (2, 12) 6 (2, 12) 4 (1, 8)
-+-+- post_p NA (NA, NA) 0.37 (0.19, 0.63) 0.37 (0.18, 0.63) 0.88 (0.58, 0.99) 0.87 (0.58, 0.98) 0.35 (0.18, 0.65)
-+-+- rate 0.113 (0.071, 0.173) 0.126 (0.064, 0.386) 0.127 (0.066, 0.302) 0.036 (0.015, 0.075) 0.035 (0.015, 0.076) 0.131 (0.062, 0.272)
-+-++ graduation 0 31 32 294 308 18
-+-++ futility 0 172 148 9 10 159
-+-++ max_n 0 52 30 38 42 43
-+-++ n 5 (2, 8) 2 (0, 5) 2 (0, 5) 2 (0, 6) 2 (0, 6) 2 (0, 5)
-+-++ n_unique 4 (2, 8) 1 (0, 5) 2 (0, 5) 2 (0, 6) 2 (0, 5) 2 (0, 5)
-+-++ post_p NA (NA, NA) 0.41 (0.25, 0.64) 0.42 (0.27, 0.6) 0.67 (0.43, 0.87) 0.65 (0.43, 0.86) 0.42 (0.26, 0.61)
-+-++ rate 0.12 (0.057, 0.251) 0.135 (0.048, 0.559) 0.128 (0.057, 0.455) 0.037 (0, 0.127) 0.038 (0, 0.122) 0.125 (0.044, 0.399)
-++– graduation 0 11 4 290 296 6
-++– futility 0 69 71 11 15 72
-++– max_n 0 0 0 0 0 0
-++– n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– post_p NA (NA, NA) 0.44 (0.43, 0.47) 0.48 (0.43, 0.57) 0.54 (0.48, 0.55) 0.64 (0.64, 0.64) NA (NA, NA)
-++– rate 0.16 (0, 0.602) 0.172 (0, 1.231) 0.103 (0, 0.484) 0.053 (0, 0.131) 0.052 (0, 0.164) 0.174 (0.079, 0.634)
-++-+ graduation 0 15 7 295 298 7
-++-+ futility 0 92 92 19 19 94
-++-+ max_n 0 0 0 0 0 0
-++-+ n 3 (0, 5) 1 (0, 4) 2 (0, 4) 1 (0, 4) 1 (0, 4) 1 (0, 3)
-++-+ n_unique 2 (0, 5) 1 (0, 3) 1 (0, 4) 1 (0, 4) 1 (0, 4) 1 (0, 3)
-++-+ post_p NA (NA, NA) 0.44 (0.32, 0.62) 0.44 (0.31, 0.62) 0.6 (0.42, 0.8) 0.62 (0.45, 0.82) 0.45 (0.3, 0.62)
-++-+ rate 0.121 (0.045, 0.388) 0.129 (0.023, 0.525) 0.136 (0.029, 0.506) 0.044 (0, 0.201) 0.034 (0, 0.136) 0.131 (0.036, 0.577)
-+++- graduation 0 13 6 292 297 7
-+++- futility 0 81 83 11 15 79
-+++- max_n 0 0 0 0 0 0
-+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- post_p NA (NA, NA) 0.46 (0.46, 0.46) 0.47 (0.45, 0.49) 0.61 (0.61, 0.61) 0.56 (0.52, 0.57) 0.54 (0.51, 0.57)
-+++- rate 0.147 (0, 1.081) 0.172 (0.056, 3) 0.099 (0, 0.426) 0 (0, 0.204) 0.023 (0, 0.258) 0.152 (0, 0.385)
-++++ graduation 0 17 9 297 299 8
-++++ futility 0 100 101 19 19 101
-++++ max_n 0 0 0 0 0 0
-++++ n 3 (1, 5) 1 (0, 3) 1 (0, 4) 2 (0, 4) 2 (0, 4) 2 (0, 3)
-++++ n_unique 2 (0, 5) 1 (0, 3) 1 (0, 4) 1 (0, 4) 1 (0, 3) 1 (0, 3)
-++++ post_p NA (NA, NA) 0.45 (0.31, 0.62) 0.45 (0.29, 0.62) 0.59 (0.44, 0.83) 0.58 (0.41, 0.78) 0.45 (0.31, 0.64)
-++++ rate 0.121 (0.042, 0.329) 0.129 (0, 0.543) 0.136 (0, 0.507) 0.036 (0, 0.159) 0.04 (0, 0.169) 0.129 (0.028, 0.522)
+—- graduation 0 6 1 14 15 3
+—- futility 0 7 3 0 0 4
+—- max_n 0 0 0 0 0 0
+—- n 5 (2, 7) 3 (1, 5) 3 (1, 6) 2 (0, 5) 2 (0, 5) 2 (0, 5)
+—- n_unique 4 (2, 7) 2 (0, 5) 3 (1, 5) 2 (0, 5) 2 (0, 4) 2 (0, 5)
+—- post_p NA (NA, NA) 0.48 (0.29, 0.73) 0.46 (0.27, 0.74) 0.48 (0.3, 0.71) 0.47 (0.31, 0.76) 0.45 (0.28, 0.72)
+—- rate 0.111 (0.05, 0.257) 0.13 (0.053, 0.402) 0.126 (0.063, 0.401) 0.131 (0.04, 0.48) 0.128 (0.043, 0.443) 0.141 (0.031, 0.566)
+—+ graduation 0 11 6 23 27 5
+—+ futility 0 35 33 8 9 42
+—+ max_n 0 0 0 0 0 0
+—+ n 2 (0, 4) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3)
+—+ n_unique 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 2) 1 (0, 3)
+—+ post_p NA (NA, NA) 0.48 (0.35, 0.66) 0.47 (0.33, 0.66) 0.49 (0.34, 0.68) 0.48 (0.35, 0.67) 0.5 (0.34, 0.68)
+—+ rate 0.127 (0.032, 0.496) 0.131 (0, 0.464) 0.148 (0.039, 0.579) 0.118 (0, 0.697) 0.143 (0, 0.808) 0.132 (0, 0.463)
+–+- graduation 0 8 3 20 23 5
+–+- futility 0 23 21 1 1 18
+–+- max_n 0 0 0 0 0 0
+–+- n 7 (4, 12) 4 (1, 7) 5 (2, 8) 3 (1, 7) 3 (1, 7) 3 (1, 8)
+–+- n_unique 6 (3, 11) 3 (1, 7) 4 (2, 8) 3 (1, 7) 3 (1, 6) 3 (1, 7)
+–+- post_p NA (NA, NA) 0.46 (0.23, 0.76) 0.47 (0.24, 0.8) 0.46 (0.24, 0.77) 0.45 (0.25, 0.8) 0.48 (0.27, 0.77)
+–+- rate 0.114 (0.066, 0.2) 0.13 (0.061, 0.395) 0.122 (0.063, 0.326) 0.132 (0.052, 0.367) 0.142 (0.051, 0.443) 0.13 (0.06, 0.37)
+–++ graduation 0 13 8 29 35 7
+–++ futility 0 47 47 9 9 51
+–++ max_n 0 0 0 0 0 0
+–++ n 3 (1, 7) 2 (0, 5) 2 (0, 4) 2 (0, 4) 2 (0, 4) 2 (1, 5)
+–++ n_unique 3 (1, 6) 2 (0, 4) 2 (0, 4) 2 (0, 4) 2 (0, 4) 2 (0, 5)
+–++ post_p NA (NA, NA) 0.49 (0.31, 0.73) 0.47 (0.29, 0.71) 0.48 (0.3, 0.72) 0.46 (0.31, 0.73) 0.49 (0.3, 0.74)
+–++ rate 0.122 (0.04, 0.276) 0.119 (0.032, 0.47) 0.136 (0.046, 0.528) 0.129 (0.04, 0.513) 0.142 (0.04, 0.617) 0.128 (0.048, 0.429)
+-+– graduation 0 11 3 21 23 6
+-+– futility 0 47 44 13 21 42
+-+– max_n 0 0 0 0 0 0
+-+– n 1 (0, 3) 1 (0, 2) 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– n_unique 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– post_p NA (NA, NA) 0.48 (0.39, 0.67) 0.49 (0.37, 0.63) 0.48 (0.38, 0.63) 0.48 (0.38, 0.65) 0.48 (0.37, 0.65)
+-+– rate 0.122 (0, 0.539) 0.14 (0, 0.622) 0.13 (0, 0.762) 0.138 (0, 0.594) 0.14 (0, 0.541) 0.133 (0, 0.742)
+-+-+ graduation 0 16 6 29 35 7
+-+-+ futility 0 71 68 21 25 64
+-+-+ max_n 0 0 0 0 0 0
+-+-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ post_p NA (NA, NA) 0.58 (0.55, 0.59) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.44 (0.44, 0.44) 0.46 (0.44, 0.47)
+-+-+ rate 0.089 (0, 1.11) 0.088 (0, 0.476) 0.119 (0, 1.14) 0.09 (0, 0.904) 0.335 (0, 1.627) 0.152 (0, 0.362)
+-++- graduation 0 13 5 26 30 7
+-++- futility 0 59 58 14 21 49
+-++- max_n 0 0 0 0 0 0
+-++- n 21 (15, 28) 8 (3, 17) 10 (4, 21) 8 (3, 19) 8 (3, 18) 8 (3, 18)
+-++- n_unique 19 (13, 26) 7 (3, 15) 9 (4, 19) 7 (3, 17) 7 (3, 16) 7 (2, 17)
+-++- post_p NA (NA, NA) 0.44 (0.17, 0.84) 0.48 (0.17, 0.85) 0.44 (0.18, 0.83) 0.47 (0.18, 0.83) 0.44 (0.19, 0.85)
+-++- rate 0.115 (0.083, 0.155) 0.129 (0.075, 0.283) 0.122 (0.082, 0.228) 0.127 (0.078, 0.263) 0.12 (0.073, 0.261) 0.128 (0.074, 0.341)
+-+++ graduation 0 18 8 34 42 8
+-+++ futility 0 79 78 22 25 71
+-+++ max_n 0 0 0 0 0 0
+-+++ n 16 (11, 22) 6 (2, 14) 7 (3, 14) 7 (2, 15) 7 (2, 14) 8 (3, 16)
+-+++ n_unique 14 (9, 20) 5 (2, 13) 6 (2, 13) 6 (2, 13) 6 (2, 13) 7 (3, 14)
+-+++ post_p NA (NA, NA) 0.47 (0.22, 0.81) 0.46 (0.18, 0.81) 0.46 (0.2, 0.82) 0.48 (0.21, 0.84) 0.46 (0.2, 0.82)
+-+++ rate 0.115 (0.08, 0.165) 0.126 (0.076, 0.3) 0.127 (0.076, 0.316) 0.126 (0.075, 0.301) 0.123 (0.073, 0.264) 0.128 (0.076, 0.281)
++— graduation 0 6 2 289 296 3
++— futility 0 33 34 0 0 38
++— max_n 0 0 0 0 0 0
++— n 8 (5, 13) 3 (1, 7) 3 (1, 7) 4 (2, 10) 5 (2, 10) 3 (1, 7)
++— n_unique 7 (4, 12) 3 (1, 6) 3 (1, 6) 4 (1, 9) 4 (1, 9) 3 (1, 6)
++— post_p NA (NA, NA) 0.39 (0.2, 0.64) 0.4 (0.21, 0.65) 0.77 (0.46, 0.96) 0.78 (0.51, 0.96) 0.38 (0.22, 0.63)
++— rate 0.115 (0.067, 0.194) 0.132 (0.05, 0.372) 0.12 (0.056, 0.321) 0.038 (0.012, 0.102) 0.037 (0.011, 0.089) 0.127 (0.054, 0.349)
++–+ graduation 0 10 7 294 298 5
++–+ futility 0 60 60 8 8 75
++–+ max_n 0 0 0 0 0 0
++–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ post_p NA (NA, NA) 0.5 (0.44, 0.52) 0.53 (0.47, 0.57) 0.5 (0.5, 0.5) NA (NA, NA) 0.46 (0.46, 0.47)
++–+ rate 0.068 (0, 0.675) 0.27 (0, 0.996) 0.111 (0, 0.614) 0 (0, 0.082) 0.066 (0, 0.343) 0.181 (0.01, 0.862)
++-+- graduation 0 8 4 291 297 5
++-+- futility 0 49 50 0 1 52
++-+- max_n 0 0 0 0 0 0
++-+- n 1 (0, 2) 0 (0, 2) 1 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2)
++-+- n_unique 1 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2)
++-+- post_p NA (NA, NA) 0.46 (0.4, 0.59) 0.47 (0.38, 0.58) 0.57 (0.43, 0.65) 0.55 (0.44, 0.66) 0.47 (0.4, 0.6)
++-+- rate 0.146 (0, 0.619) 0.148 (0, 1.051) 0.144 (0, 0.644) 0.032 (0, 0.192) 0.031 (0, 0.23) 0.146 (0, 0.73)
++-++ graduation 0 12 9 296 299 7
++-++ futility 0 72 73 8 8 84
++-++ max_n 0 0 0 0 0 0
++-++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ post_p NA (NA, NA) 0.55 (0.55, 0.55) 0.5 (0.44, 0.56) 0.58 (0.58, 0.58) 0.57 (0.57, 0.57) 0.46 (0.46, 0.46)
++-++ rate 0.153 (0, 0.433) 0.077 (0, 0.61) 0.197 (0, 0.608) 0.029 (0, 0.123) 0.04 (0, 0.176) 0.15 (0, 2.599)
+++– graduation 0 11 4 290 296 6
+++– futility 0 69 71 11 15 72
+++– max_n 0 0 0 0 0 0
+++– n 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– n_unique 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– post_p NA (NA, NA) 0.48 (0.43, 0.57) 0.5 (0.41, 0.57) 0.54 (0.47, 0.59) 0.53 (0.46, 0.59) 0.5 (0.41, 0.57)
+++– rate 0.125 (0, 0.904) 0.116 (0, 1.111) 0.11 (0, 0.417) 0.038 (0, 0.165) 0.02 (0, 0.215) 0.147 (0, 0.684)
+++-+ graduation 0 15 7 295 298 7
+++-+ futility 0 92 92 19 19 94
+++-+ max_n 0 0 0 0 0 0
+++-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ post_p NA (NA, NA) 0.53 (0.53, 0.53) 0.52 (0.52, 0.52) 0.48 (0.48, 0.48) 0.56 (0.5, 0.58) NA (NA, NA)
+++-+ rate 0.133 (0, 0.634) 0.128 (0, 0.41) 0.06 (0, 0.199) 0.075 (0, 1.073) 0.055 (0, 0.185) 0.043 (0, 0.759)
++++- graduation 0 13 6 292 297 7
++++- futility 0 81 83 11 15 79
++++- max_n 0 0 0 0 0 0
++++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- post_p NA (NA, NA) 0.46 (0.46, 0.46) 0.52 (0.52, 0.52) 0.55 (0.49, 0.56) 0.54 (0.52, 0.58) 0.45 (0.43, 0.5)
++++- rate 0.221 (0, 0.594) 0.147 (0, 4.556) 0.16 (0, 0.355) 0.036 (0, 0.133) 0.04 (0, 0.462) 0.214 (0, 1.166)
+++++ graduation 0 17 9 297 299 8
+++++ futility 0 100 101 19 19 101
+++++ max_n 0 0 0 0 0 0
+++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ post_p NA (NA, NA) 0.44 (0.44, 0.44) 0.51 (0.5, 0.54) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52)
+++++ rate 0.122 (0, 1.294) 0.283 (0, 7.532) 0.105 (0, 1.081) 0 (0, 0.09) 0.057 (0, 0.512) 0.128 (0, 0.355)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4 TC5
all count 6 1 14 15 3
all time_stop 5 (3, 6) 4 (4, 4) 7 (6, 9) 8 (6, 13) 7 (7, 7)
all n_trt 33 (26, 38) 25 (25, 25) 30 (27, 35) 30 (25, 50) 27 (27, 31)
all n_control 46 (33, 63) 48 (48, 48) 68 (53, 86) 70 (55, 119) 68 (61, 78)
all post_p 0.87 (0.86, 0.9) 0.92 (0.92, 0.92) 0.97 (0.89, 1) 0.99 (0.9, 1) 0.9 (0.87, 0.91)
all order 1 (1, 1) 1 (1, 1) 1 (1, 1) 1 (1, 1) 1 (1, 1)
AR- & TP53- count 20 24 39 50 13
AR- & TP53- time_stop 9 (6, 14) 10 (7, 14) 14 (9, 25) 14 (10, 27) 12 (10, 14)
AR- & TP53- n_trt 33 (26, 61) 29 (25, 43) 40 (26, 92) 35 (25, 88) 32 (25, 45)
AR- & TP53- n_control 46 (32, 79) 52 (39, 80) 71 (53, 142) 79 (54, 165) 59 (51, 82)
AR- & TP53- post_p 0.91 (0.88, 0.96) 0.9 (0.86, 0.94) 0.99 (0.94, 1) 0.99 (0.95, 1) 0.92 (0.88, 0.98)
AR- & TP53- order 1 (1, 1.2) 1 (1, 1) 1 (1, 3) 1 (1, 2.1) 1 (1, 2)
HRD+ count 1 275 281
HRD+ time_stop 26 (26, 26) 23 (17, 33) 24 (17, 32)
HRD+ n_trt 25 (25, 25) 27 (25, 45) 28 (25, 42)
HRD+ n_control 41 (41, 41) 32 (22, 52) 36 (22, 52)
HRD+ post_p 0.93 (0.93, 0.93) 1 (0.98, 1) 1 (0.98, 1)
HRD+ order 5 (5, 5) 1 (1, 3) 2 (1, 3)
TP53+ count 5 2 7 8 3
TP53+ time_stop 17 (14, 21) 16 (14, 17) 19 (13, 23) 18 (15, 22) 15 (13, 23)
TP53+ n_trt 34 (29, 44) 27 (25, 29) 30 (28, 35) 33 (27, 42) 32 (26, 38)
TP53+ n_control 49 (35, 64) 42 (41, 43) 47 (35, 72) 51 (36, 72) 42 (37, 82)
TP53+ post_p 0.93 (0.87, 0.98) 0.94 (0.9, 0.97) 0.98 (0.94, 0.99) 0.98 (0.95, 0.99) 0.94 (0.93, 0.96)
TP53+ order 1 (1, 2) 1.5 (1.1, 1.9) 1 (1, 2) 2 (1, 2) 2 (1.2, 2)
TEfus+ count 2 2 6 9 2
TEfus+ time_stop 12 (10, 14) 16 (15, 16) 12 (10, 20) 18 (13, 19) 14 (12, 15)
TEfus+ n_trt 26 (26, 26) 36 (36, 36) 26 (25, 36) 27 (25, 37) 28 (26, 30)
TEfus+ n_control 41 (34, 48) 45 (40, 50) 32 (24, 60) 45 (31, 54) 33 (31, 35)
TEfus+ post_p 0.92 (0.87, 0.98) 0.89 (0.89, 0.9) 0.98 (0.95, 0.99) 0.98 (0.95, 1) 0.9 (0.87, 0.93)
TEfus+ order 1 (1, 1) 1 (1, 1) 1 (1, 2.5) 1 (1, 3) 1.5 (1.1, 1.9)
PI3K+ count 5 5 9 12 2
PI3K+ time_stop 22 (14, 24) 14 (12, 18) 15 (14, 19) 16 (13, 22) 15 (13, 17)
PI3K+ n_trt 38 (31, 49) 26 (25, 27) 28 (26, 33) 26 (25, 37) 36 (32, 40)
PI3K+ n_control 69 (50, 81) 41 (35, 47) 45 (30, 64) 52 (37, 72) 46 (40, 51)
PI3K+ post_p 0.96 (0.9, 0.99) 0.96 (0.89, 0.99) 0.96 (0.95, 0.99) 0.99 (0.91, 0.99) 0.92 (0.9, 0.94)
PI3K+ order 1 (1, 3.2) 2 (1, 2) 1 (1, 2.2) 1 (1, 2.9) 1 (1, 1)
Futility:
signature var TC1 TC2 TC3 TC4 TC5
all count 7 3 4
all time_stop 6 (4, 7) 5 (3, 5) 10 (10, 11)
all n_trt 32 (27, 42) 25 (25, 27) 50 (37, 54)
all n_control 54 (31, 62) 49 (29, 51) 92 (77, 106)
all post_p 0.04 (0.01, 0.17) 0.07 (0.04, 0.14) 0.01 (0, 0.11)
all order 1 (1, 2) 1 (1, 1) 1 (1, 1.7)
AR- & TP53- count 131 103 1 2 101
AR- & TP53- time_stop 13 (6, 29) 18 (11, 33) 11 (11, 11) 17 (15, 19) 20 (11, 33)
AR- & TP53- n_trt 40 (26, 73) 35 (26, 78) 26 (26, 26) 37 (27, 47) 39 (26, 65)
AR- & TP53- n_control 68 (36, 166) 98 (55, 191) 58 (58, 58) 94 (80, 108) 107 (49, 193)
AR- & TP53- post_p 0.13 (0.03, 0.23) 0.16 (0.03, 0.27) 0.27 (0.27, 0.27) 0.19 (0.15, 0.23) 0.1 (0.04, 0.24)
AR- & TP53- order 1 (1, 2) 1 (1, 3) 1 (1, 1) 3 (1.4, 4.6) 2 (1, 3)
HRD+ count 26 31 34
HRD+ time_stop 32 (28, 35) 34 (26, 36) 32 (25, 36)
HRD+ n_trt 27 (25, 40) 27 (25, 35) 26 (25, 32)
HRD+ n_control 52 (40, 69) 51 (39, 65) 52 (36, 66)
HRD+ post_p 0.15 (0.02, 0.25) 0.14 (0.07, 0.28) 0.11 (0.03, 0.24)
HRD+ order 2 (1, 4) 2 (1, 3) 2 (1, 3)
TP53+ count 40 41 13 21 38
TP53+ time_stop 20 (15, 33) 21 (14, 30) 21 (17, 33) 24 (19, 32) 24 (13, 32)
TP53+ n_trt 33 (26, 45) 31 (25, 52) 27 (25, 36) 31 (25, 39) 31 (25, 47)
TP53+ n_control 62 (37, 118) 67 (40, 98) 55 (47, 107) 76 (58, 102) 70 (35, 110)
TP53+ post_p 0.09 (0.02, 0.18) 0.07 (0.02, 0.22) 0.11 (0.01, 0.19) 0.11 (0.01, 0.21) 0.08 (0.01, 0.22)
TP53+ order 1.5 (1, 3) 2 (1, 3) 2 (1, 3) 2 (1, 3) 2 (1, 3)
TEfus+ count 16 18 1 1 15
TEfus+ time_stop 22 (19, 32) 17 (14, 26) 15 (15, 15) 25 (25, 25) 19 (12, 28)
TEfus+ n_trt 28 (26, 36) 29 (25, 42) 25 (25, 25) 39 (39, 39) 30 (25, 41)
TEfus+ n_control 64 (50, 103) 52 (35, 82) 30 (30, 30) 82 (82, 82) 52 (32, 87)
TEfus+ post_p 0.06 (0.02, 0.17) 0.07 (0.01, 0.22) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.06 (0, 0.16)
TEfus+ order 2 (1, 5) 3 (1, 3.3) 1 (1, 1) 4 (4, 4) 2 (1, 3)
PI3K+ count 28 30 8 9 40
PI3K+ time_stop 24 (16, 32) 20 (17, 30) 18 (15, 26) 26 (22, 32) 20 (9, 30)
PI3K+ n_trt 32 (26, 41) 28 (25, 43) 28 (26, 35) 37 (26, 48) 30 (25, 53)
PI3K+ n_control 68 (41, 103) 63 (47, 97) 55 (45, 79) 88 (67, 120) 56 (24, 96)
PI3K+ post_p 0.07 (0, 0.24) 0.06 (0.01, 0.22) 0.1 (0.01, 0.27) 0.09 (0.04, 0.29) 0.08 (0.02, 0.19)
PI3K+ order 2 (1, 3) 2 (1, 3.1) 2 (1, 3.3) 3 (1, 4.2) 2 (1, 3)


By subgroup combinations

Graduation:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
all TC1 time 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6)
all TC1 n 18 (14, 21) 2 (0, 4) 0 (0, 1) 0 (0, 2) 4 (2, 6) 1 (0, 3) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (0, 2) 0 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.63 (0.55, 0.78) 0.56 (0.55, 0.62) 0.5 (0.5, 0.5) 0.52 (0.52, 0.56) 0.56 (0.51, 0.61) 0.55 (0.53, 0.57) NA (NA, NA) 0.54 (0.53, 0.57) 0.5 (0.5, 0.5) NA (NA, NA) 0.51 (0.5, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.56 (0.54, 0.59) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.54 (0.52, 0.54) 0.59 (0.54, 0.6) 0.51 (0.5, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.05 (0.035, 0.076) 0 (0, 0) 0 (0, 0) 0 (0, 0.26) 0 (0, 0.108) 0 (0, 1.867) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0.103) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
all TC2 time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
all TC2 n 9 (9, 9) 0 (0, 0) 1 (1, 1) 0 (0, 0) 3 (3, 3) 2 (2, 2) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 1 (1, 1) 0 (0, 0) 1 (1, 1) 0 (0, 0) 3 (3, 3) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.86 (0.86, 0.86) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.62 (0.62, 0.62) 0.53 (0.53, 0.53) NA (NA, NA) 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 5.034 (5.034, 5.034) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 count 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14
all TC3 time 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9) 7 (6, 9)
all TC3 n 6 (4, 14) 1 (0, 2) 0 (0, 2) 1 (0, 1) 2 (0, 4) 2 (1, 3) 0 (0, 1) 1 (0, 3) 4 (2, 9) 0 (0, 0) 2 (1, 5) 1 (0, 3) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 2 (0, 3) 1 (0, 2) 2 (1, 4) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.64 (0.54, 0.76) 0.56 (0.54, 0.66) 0.67 (0.67, 0.67) 0.52 (0.51, 0.57) 0.57 (0.51, 0.65) 0.58 (0.52, 0.66) 0.51 (0.51, 0.51) 0.53 (0.5, 0.55) 0.58 (0.54, 0.66) NA (NA, NA) 0.54 (0.51, 0.6) 0.55 (0.51, 0.63) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) 0.52 (0.52, 0.55) 0.52 (0.5, 0.53) NA (NA, NA) 0.52 (0.51, 0.54) 0.54 (0.51, 0.58) NA (NA, NA) NA (NA, NA) 0.55 (0.5, 0.6) 0.55 (0.54, 0.63) 0.55 (0.53, 0.59) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC3 rate 0.019 (0, 0.12) 0 (0, 0.024) 0 (0, 0.073) 0 (0, 0) 0 (0, 0.167) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.092) NA (NA, NA) 0 (0, 0.13) 0 (0, 0.019) 3.523 (3.523, 3.523) 0 (0, 2.039) NA (NA, NA) 0 (0, 0.151) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.602) NA (NA, NA) NA (NA, NA) 0 (0, 0.124) 0 (0, 0) 0 (0, 0.07) NA (NA, NA) 0.11 (0.022, 0.198) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA)
all TC4 count 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15
all TC4 time 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13)
all TC4 n 9 (4, 15) 1 (0, 5) 0 (0, 0) 1 (0, 2) 2 (0, 6) 2 (0, 4) 0 (0, 1) 1 (0, 4) 5 (2, 8) 0 (0, 0) 2 (0, 5) 1 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 1) 0 (0, 0) 2 (1, 4) 1 (0, 3) 1 (0, 4) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.6 (0.55, 0.79) 0.63 (0.54, 0.66) NA (NA, NA) 0.56 (0.5, 0.7) 0.56 (0.52, 0.64) 0.57 (0.53, 0.68) 0.54 (0.51, 0.59) 0.55 (0.5, 0.8) 0.57 (0.52, 0.78) NA (NA, NA) 0.59 (0.54, 0.82) 0.54 (0.52, 0.62) NA (NA, NA) 0.57 (0.55, 0.6) NA (NA, NA) 0.57 (0.55, 0.62) 0.56 (0.56, 0.56) NA (NA, NA) 0.54 (0.52, 0.56) 0.54 (0.53, 0.55) 0.54 (0.54, 0.54) NA (NA, NA) 0.55 (0.53, 0.65) 0.62 (0.53, 0.72) 0.53 (0.5, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC4 rate 0.079 (0, 0.11) 0 (0, 0) 0 (0, 0) 0 (0, 0.317) 0 (0, 0.085) 0 (0, 0.103) 0 (0, 0) 0 (0, 0.123) 0 (0, 0.031) NA (NA, NA) 0 (0, 0.017) 0 (0, 0) NA (NA, NA) 0 (0, 0.012) NA (NA, NA) 0 (0, 0.178) 0 (0, 0) NA (NA, NA) 0 (0, 0.037) 0 (0, 0) 0 (0, 0.081) NA (NA, NA) 0 (0, 0.095) 0 (0, 0.068) 0 (0, 0.103) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA)
all TC5 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
all TC5 time 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7)
all TC5 n 5 (5, 6) 7 (5, 8) 0 (0, 1) 1 (0, 2) 3 (3, 5) 4 (2, 4) 0 (0, 0) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 2) 0 (0, 1) 1 (0, 2) 1 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 4 (3, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1)
all TC5 post_p 0.65 (0.56, 0.68) 0.67 (0.65, 0.73) 0.51 (0.51, 0.51) 0.53 (0.52, 0.54) 0.54 (0.53, 0.71) 0.54 (0.52, 0.59) NA (NA, NA) NA (NA, NA) 0.53 (0.51, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.58 (0.58, 0.58) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) 0.51 (0.51, 0.51) 0.6 (0.54, 0.61) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 rate 0 (0, 0.082) 0.048 (0.032, 0.099) 0 (0, 0) 0 (0, 0) 0 (0, 0.08) 0.073 (0.071, 0.116) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.093 (0.019, 0.152) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0)
AR- & TP53- TC1 count 20 20 20 20 20 20 20 20
AR- & TP53- TC1 time 9 (6, 14) 9 (6, 14) 9 (6, 14) 9 (6, 14) 9 (6, 14) 9 (6, 14) 9 (6, 14) 9 (6, 14)
AR- & TP53- TC1 n 23 (18, 39) 4 (2, 9) 1 (0, 2) 2 (0, 4) 1 (0, 4) 0 (0, 0) 1 (0, 2) 0 (0, 1)
AR- & TP53- TC1 post_p 0.82 (0.74, 0.93) 0.71 (0.53, 0.78) 0.53 (0.51, 0.55) 0.6 (0.55, 0.74) 0.56 (0.51, 0.65) NA (NA, NA) 0.53 (0.53, 0.71) 0.53 (0.53, 0.54)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.073 (0.055, 0.097) 0.032 (0, 0.083) 0 (0, 0.22) 0 (0, 0.068) 0 (0, 0.041) NA (NA, NA) 0 (0, 0) 0 (0, 0.428)
AR- & TP53- TC2 count 24 24 24 24 24 24 24 24
AR- & TP53- TC2 time 10 (7, 14) 10 (7, 14) 10 (7, 14) 10 (7, 14) 10 (7, 14) 10 (7, 14) 10 (7, 14) 10 (7, 14)
AR- & TP53- TC2 n 21 (16, 31) 3 (1, 4) 0 (0, 3) 2 (0, 4) 2 (1, 5) 0 (0, 0) 0 (0, 2) 0 (0, 1)
AR- & TP53- TC2 post_p 0.81 (0.73, 0.94) 0.6 (0.52, 0.69) 0.58 (0.54, 0.63) 0.55 (0.52, 0.66) 0.55 (0.51, 0.61) NA (NA, NA) 0.54 (0.51, 0.58) 0.53 (0.5, 0.56)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.067 (0.046, 0.095) 0 (0, 0.098) 0 (0, 0.239) 0 (0, 0.065) 0 (0, 0.064) NA (NA, NA) 0 (0, 0.335) 0 (0, 0.148)
AR- & TP53- TC3 count 39 39 39 39 39 39 39 39
AR- & TP53- TC3 time 14 (9, 25) 14 (9, 25) 14 (9, 25) 14 (9, 25) 14 (9, 25) 14 (9, 25) 14 (9, 25) 14 (9, 25)
AR- & TP53- TC3 n 19 (12, 55) 4 (0, 11) 0 (0, 2) 3 (0, 5) 8 (4, 15) 0 (0, 0) 3 (2, 8) 1 (0, 3)
AR- & TP53- TC3 post_p 0.8 (0.72, 0.93) 0.62 (0.52, 0.77) 0.56 (0.5, 0.71) 0.58 (0.51, 0.75) 0.8 (0.6, 0.96) NA (NA, NA) 0.62 (0.53, 0.85) 0.59 (0.53, 0.67)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.079 (0.043, 0.094) 0.072 (0, 0.116) 0 (0, 0.263) 0.054 (0, 0.131) 0.029 (0, 0.056) NA (NA, NA) 0.017 (0, 0.065) 0 (0, 0.103)
AR- & TP53- TC4 count 50 50 50 50 50 50 50 50
AR- & TP53- TC4 time 14 (10, 27) 14 (10, 27) 14 (10, 27) 14 (10, 27) 14 (10, 27) 14 (10, 27) 14 (10, 27) 14 (10, 27)
AR- & TP53- TC4 n 18 (10, 44) 4 (1, 13) 0 (0, 2) 2 (0, 5) 8 (4, 17) 0 (0, 0) 4 (2, 7) 1 (0, 4)
AR- & TP53- TC4 post_p 0.79 (0.7, 0.92) 0.59 (0.52, 0.79) 0.56 (0.51, 0.66) 0.62 (0.53, 0.83) 0.75 (0.58, 0.96) NA (NA, NA) 0.63 (0.52, 0.89) 0.57 (0.52, 0.77)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.079 (0.036, 0.103) 0.067 (0, 0.128) 0 (0, 0.126) 0.057 (0, 0.106) 0.028 (0, 0.053) NA (NA, NA) 0.016 (0, 0.056) 0 (0, 0.096)
AR- & TP53- TC5 count 13 13 13 13 13 13 13 13
AR- & TP53- TC5 time 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14)
AR- & TP53- TC5 n 18 (12, 25) 8 (4, 11) 0 (0, 2) 3 (0, 5) 2 (0, 4) 0 (0, 0) 0 (0, 2) 0 (0, 1)
AR- & TP53- TC5 post_p 0.8 (0.72, 0.86) 0.76 (0.64, 0.84) 0.55 (0.53, 0.58) 0.62 (0.56, 0.72) 0.54 (0.52, 0.72) NA (NA, NA) 0.55 (0.52, 0.59) 0.55 (0.54, 0.56)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.068 (0.031, 0.093) 0.043 (0.031, 0.091) 0.181 (0, 0.689) 0.066 (0.029, 0.114) 0 (0, 0.095) NA (NA, NA) 0 (0, 0) 0 (0, 0.337)
HRD+ TC2 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
HRD+ TC2 time 26 (26, 26) 26 (26, 26) 26 (26, 26) 26 (26, 26) 26 (26, 26) 26 (26, 26) 26 (26, 26) 26 (26, 26) 26 (26, 26) 26 (26, 26) 26 (26, 26) 26 (26, 26) 26 (26, 26) 26 (26, 26) 26 (26, 26) 26 (26, 26)
HRD+ TC2 n 12 (12, 12) 0 (0, 0) 5 (5, 5) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 5 (5, 5) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.82 (0.82, 0.82) NA (NA, NA) 0.5 (0.5, 0.5) 0.56 (0.56, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.63 (0.63, 0.63) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.044 (0.044, 0.044) NA (NA, NA) 0.111 (0.111, 0.111) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.043 (0.043, 0.043) 0.08 (0.08, 0.08) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC3 count 275 275 275 275 275 275 275 275 275 275 275 275 275 275 275 275
HRD+ TC3 time 23 (17, 33) 23 (17, 33) 23 (17, 33) 23 (17, 33) 23 (17, 33) 23 (17, 33) 23 (17, 33) 23 (17, 33) 23 (17, 33) 23 (17, 33) 23 (17, 33) 23 (17, 33) 23 (17, 33) 23 (17, 33) 23 (17, 33) 23 (17, 33)
HRD+ TC3 n 13 (8, 21) 0 (0, 0) 6 (3, 11) 2 (0, 5) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 4) 4 (1, 9) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.92 (0.74, 1) 0.57 (0.57, 0.57) 0.76 (0.55, 0.93) 0.6 (0.52, 0.78) 0.53 (0.53, 0.53) 0.56 (0.52, 0.69) 0.58 (0.58, 0.58) 0.58 (0.51, 0.71) 0.68 (0.53, 0.9) NA (NA, NA) 0.56 (0.51, 0.67) 0.6 (0.6, 0.6) 0.55 (0.51, 0.59) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.032 (0.015, 0.054) 0 (0, 0.343) 0.032 (0, 0.068) 0.021 (0, 0.088) 0 (0, 0.093) 0 (0, 0.114) 0 (0, 0.155) 0 (0, 0.086) 0.028 (0, 0.078) 0 (0, 0.121) 0 (0, 0.116) 0.061 (0, 0.123) 0 (0, 0.15) 0.082 (0, 1.001) 0 (0, 0.736) 0 (0, 0.072)
HRD+ TC4 count 281 281 281 281 281 281 281 281 281 281 281 281 281 281 281 281
HRD+ TC4 time 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32) 24 (17, 32)
HRD+ TC4 n 13 (9, 21) 0 (0, 0) 6 (3, 11) 2 (0, 5) 0 (0, 0) 1 (0, 4) 0 (0, 0) 1 (0, 3) 4 (2, 8) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.92 (0.74, 0.99) NA (NA, NA) 0.75 (0.56, 0.95) 0.6 (0.52, 0.78) 0.58 (0.58, 0.58) 0.58 (0.51, 0.73) 0.55 (0.54, 0.55) 0.56 (0.51, 0.7) 0.7 (0.54, 0.89) NA (NA, NA) 0.56 (0.51, 0.66) 0.58 (0.58, 0.58) 0.54 (0.51, 0.57) 0.53 (0.52, 0.55) 0.55 (0.51, 0.58) NA (NA, NA)
HRD+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.033 (0.014, 0.054) 0.025 (0, 0.849) 0.031 (0, 0.068) 0.025 (0, 0.082) 0 (0, 0.232) 0.015 (0, 0.087) 0.045 (0, 0.223) 0 (0, 0.091) 0.029 (0, 0.072) 0 (0, 0.066) 0 (0, 0.159) 0 (0, 0.059) 0 (0, 0.206) 0 (0, 0.39) 0.073 (0, 1.178) 0 (0, 0.21)
TP53+ TC1 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
TP53+ TC1 time 17 (14, 21) 17 (14, 21) 17 (14, 21) 17 (14, 21) 17 (14, 21) 17 (14, 21) 17 (14, 21) 17 (14, 21) 17 (14, 21) 17 (14, 21) 17 (14, 21) 17 (14, 21) 17 (14, 21) 17 (14, 21) 17 (14, 21) 17 (14, 21)
TP53+ TC1 n 8 (6, 12) 7 (2, 14) 4 (1, 5) 4 (3, 13) 0 (0, 0) 1 (0, 3) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 4 (3, 7) 3 (0, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.77 (0.72, 0.86) 0.72 (0.56, 0.75) 0.55 (0.53, 0.56) 0.74 (0.7, 0.87) NA (NA, NA) 0.55 (0.51, 0.65) NA (NA, NA) 0.61 (0.61, 0.61) 0.51 (0.51, 0.51) NA (NA, NA) 0.7 (0.6, 0.78) 0.63 (0.54, 0.7) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.07 (0.057, 0.083) 0.071 (0.023, 0.096) 0.12 (0.032, 0.184) 0.08 (0.031, 0.095) NA (NA, NA) 0 (0, 0.022) NA (NA, NA) 0.077 (0.015, 0.138) 0 (0, 0) NA (NA, NA) 0.102 (0.043, 0.165) 0.061 (0.037, 0.113) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
TP53+ TC2 time 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17) 16 (14, 17)
TP53+ TC2 n 4 (4, 4) 4 (4, 4) 4 (3, 4) 3 (1, 5) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 7 (5, 9) 4 (2, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1)
TP53+ TC2 post_p 0.72 (0.63, 0.81) 0.77 (0.63, 0.91) 0.58 (0.58, 0.59) 0.56 (0.56, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.69 (0.68, 0.71) 0.55 (0.54, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.047 (0.034, 0.059) 0.031 (0.026, 0.035) 0.081 (0.053, 0.108) 0.059 (0.012, 0.107) NA (NA, NA) 0.054 (0.054, 0.054) NA (NA, NA) NA (NA, NA) 0.191 (0.191, 0.191) NA (NA, NA) 0.091 (0.069, 0.113) 0.087 (0.059, 0.115) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0)
TP53+ TC3 count 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
TP53+ TC3 time 19 (13, 23) 19 (13, 23) 19 (13, 23) 19 (13, 23) 19 (13, 23) 19 (13, 23) 19 (13, 23) 19 (13, 23) 19 (13, 23) 19 (13, 23) 19 (13, 23) 19 (13, 23) 19 (13, 23) 19 (13, 23) 19 (13, 23) 19 (13, 23)
TP53+ TC3 n 7 (4, 12) 5 (2, 9) 1 (0, 3) 4 (2, 9) 0 (0, 0) 1 (1, 2) 0 (0, 0) 1 (1, 2) 0 (0, 0) 0 (0, 0) 4 (3, 7) 5 (2, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.8 (0.51, 0.87) 0.71 (0.53, 0.78) 0.57 (0.51, 0.6) 0.64 (0.56, 0.88) NA (NA, NA) 0.52 (0.51, 0.52) NA (NA, NA) 0.56 (0.51, 0.61) NA (NA, NA) NA (NA, NA) 0.69 (0.54, 0.8) 0.54 (0.52, 0.81) 0.59 (0.59, 0.59) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.059 (0.044, 0.111) 0.1 (0.032, 0.122) 0 (0, 0.053) 0.034 (0, 0.141) NA (NA, NA) 0 (0, 0.134) NA (NA, NA) 0.015 (0, 0.273) NA (NA, NA) NA (NA, NA) 0.066 (0.028, 0.13) 0.057 (0.018, 0.129) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA)
TP53+ TC4 count 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8
TP53+ TC4 time 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22)
TP53+ TC4 n 8 (5, 12) 7 (3, 12) 2 (0, 2) 4 (2, 6) 0 (0, 0) 1 (0, 2) 0 (0, 0) 2 (0, 3) 0 (0, 0) 0 (0, 0) 5 (4, 8) 4 (2, 9) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.78 (0.69, 0.93) 0.72 (0.63, 0.81) 0.55 (0.51, 0.59) 0.57 (0.53, 0.76) NA (NA, NA) 0.55 (0.53, 0.56) NA (NA, NA) 0.56 (0.54, 0.58) NA (NA, NA) NA (NA, NA) 0.73 (0.58, 0.8) 0.68 (0.52, 0.82) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.059 (0.049, 0.075) 0.061 (0.034, 0.086) 0.047 (0, 0.173) 0.055 (0, 0.098) NA (NA, NA) 0 (0, 0.046) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.061 (0.023, 0.105) 0.082 (0.013, 0.142) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA)
TP53+ TC5 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TP53+ TC5 time 15 (13, 23) 15 (13, 23) 15 (13, 23) 15 (13, 23) 15 (13, 23) 15 (13, 23) 15 (13, 23) 15 (13, 23) 15 (13, 23) 15 (13, 23) 15 (13, 23) 15 (13, 23) 15 (13, 23) 15 (13, 23) 15 (13, 23) 15 (13, 23)
TP53+ TC5 n 5 (3, 10) 7 (2, 10) 2 (1, 3) 5 (4, 8) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 2) 0 (0, 0) 2 (1, 11) 4 (2, 9) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 post_p 0.75 (0.66, 0.91) 0.81 (0.6, 0.85) 0.53 (0.51, 0.56) 0.71 (0.57, 0.73) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) 0.56 (0.55, 0.71) 0.62 (0.59, 0.71) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 r_prob 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 rate 0.033 (0.007, 0.058) 0.049 (0.01, 0.057) 0.12 (0.024, 0.138) 0.041 (0.008, 0.108) NA (NA, NA) 0.077 (0.077, 0.077) NA (NA, NA) 0 (0, 0) 0.204 (0.204, 0.204) NA (NA, NA) 0 (0, 0.044) 0.084 (0.017, 0.124) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
TEfus+ TC1 time 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14)
TEfus+ TC1 n 2 (1, 3) 4 (4, 4) 1 (0, 2) 3 (1, 5) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 1) 2 (1, 2) 2 (0, 3) 7 (5, 9) 4 (4, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.53 (0.53, 0.54) 0.59 (0.59, 0.59) 0.56 (0.56, 0.56) 0.63 (0.55, 0.71) 0.56 (0.56, 0.56) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) 0.62 (0.62, 0.62) 0.74 (0.57, 0.92) 0.75 (0.75, 0.75) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.138 (0.084, 0.191) 0.069 (0.046, 0.092) 0 (0, 0) 0.022 (0.004, 0.039) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.032 (0.006, 0.058) 0 (0, 0) 0.077 (0.033, 0.12) 0.054 (0.011, 0.097) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
TEfus+ TC2 time 16 (15, 16) 16 (15, 16) 16 (15, 16) 16 (15, 16) 16 (15, 16) 16 (15, 16) 16 (15, 16) 16 (15, 16) 16 (15, 16) 16 (15, 16) 16 (15, 16) 16 (15, 16) 16 (15, 16) 16 (15, 16) 16 (15, 16) 16 (15, 16)
TEfus+ TC2 n 0 (0, 1) 2 (1, 3) 4 (4, 5) 4 (3, 4) 2 (0, 3) 3 (2, 4) 0 (0, 0) 2 (1, 2) 2 (1, 3) 1 (1, 1) 10 (9, 10) 6 (5, 7) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p NA (NA, NA) 0.68 (0.57, 0.79) 0.53 (0.51, 0.55) 0.51 (0.51, 0.51) 0.57 (0.57, 0.57) 0.58 (0.58, 0.58) NA (NA, NA) NA (NA, NA) 0.57 (0.56, 0.57) 0.55 (0.55, 0.55) 0.76 (0.75, 0.76) 0.66 (0.6, 0.72) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.283 (0.283, 0.283) 0.024 (0.005, 0.043) 0.117 (0.107, 0.127) 0.135 (0.131, 0.14) 0 (0, 0) 0.115 (0.023, 0.207) NA (NA, NA) 0.104 (0.021, 0.187) 0.037 (0.007, 0.067) 0 (0, 0) 0.08 (0.049, 0.111) 0.089 (0.084, 0.095) 0.113 (0.023, 0.203) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
TEfus+ TC3 time 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20)
TEfus+ TC3 n 1 (0, 2) 4 (1, 4) 2 (0, 2) 2 (1, 4) 4 (2, 8) 2 (1, 2) 0 (0, 0) 1 (0, 2) 1 (0, 4) 1 (0, 2) 4 (2, 4) 6 (4, 9) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.54 (0.54, 0.54) 0.63 (0.57, 0.68) 0.55 (0.51, 0.67) 0.6 (0.54, 0.65) 0.65 (0.59, 0.79) 0.55 (0.54, 0.56) NA (NA, NA) 0.57 (0.53, 0.6) 0.57 (0.52, 0.71) 0.52 (0.52, 0.53) 0.6 (0.53, 0.66) 0.64 (0.52, 0.81) 0.58 (0.58, 0.58) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.037 (0, 0.521) 0.076 (0.025, 0.085) 0 (0, 0.056) 0 (0, 0.028) 0 (0, 0.037) 0 (0, 0.082) NA (NA, NA) 0.015 (0, 0.102) 0.048 (0, 0.209) 0 (0, 4.559) 0.058 (0.022, 0.113) 0.084 (0.021, 0.14) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9
TEfus+ TC4 time 18 (13, 19) 18 (13, 19) 18 (13, 19) 18 (13, 19) 18 (13, 19) 18 (13, 19) 18 (13, 19) 18 (13, 19) 18 (13, 19) 18 (13, 19) 18 (13, 19) 18 (13, 19) 18 (13, 19) 18 (13, 19) 18 (13, 19) 18 (13, 19)
TEfus+ TC4 n 1 (0, 2) 3 (2, 6) 1 (1, 4) 3 (1, 9) 3 (2, 4) 2 (1, 3) 0 (0, 0) 2 (0, 4) 2 (1, 2) 1 (0, 1) 5 (3, 10) 5 (3, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.64 (0.56, 0.74) 0.61 (0.52, 0.88) 0.58 (0.54, 0.66) 0.62 (0.53, 0.88) 0.64 (0.58, 0.85) 0.54 (0.52, 0.62) NA (NA, NA) 0.59 (0.52, 0.63) 0.62 (0.57, 0.68) 0.56 (0.56, 0.56) 0.6 (0.53, 0.94) 0.56 (0.51, 0.75) 0.54 (0.53, 0.55) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0 (0, 0) 0.062 (0, 0.16) 0 (0, 0.049) 0.035 (0, 0.068) 0.012 (0, 0.043) 0.016 (0, 0.069) NA (NA, NA) 0.021 (0, 0.052) 0 (0, 0.099) 0.275 (0, 0.572) 0.067 (0, 0.104) 0.059 (0.029, 0.116) 0.114 (0, 0.492) 0.09 (0.09, 0.09) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
TEfus+ TC5 time 14 (12, 15) 14 (12, 15) 14 (12, 15) 14 (12, 15) 14 (12, 15) 14 (12, 15) 14 (12, 15) 14 (12, 15) 14 (12, 15) 14 (12, 15) 14 (12, 15) 14 (12, 15) 14 (12, 15) 14 (12, 15) 14 (12, 15) 14 (12, 15)
TEfus+ TC5 n 1 (1, 1) 2 (2, 3) 2 (1, 2) 10 (9, 10) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 1) 1 (0, 2) 0 (0, 1) 1 (1, 1) 10 (9, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 post_p 0.57 (0.57, 0.57) 0.57 (0.52, 0.62) 0.54 (0.53, 0.56) 0.72 (0.7, 0.74) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) 0.57 (0.57, 0.57) 0.54 (0.54, 0.54) 0.52 (0.51, 0.54) 0.82 (0.75, 0.89) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 rate 0 (0, 0) 0.126 (0.025, 0.227) 0 (0, 0) 0.032 (0.006, 0.058) NA (NA, NA) 0.21 (0.184, 0.235) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.074 (0.015, 0.133) 0.065 (0.05, 0.08) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
PI3K+ TC1 time 22 (14, 24) 22 (14, 24) 22 (14, 24) 22 (14, 24) 22 (14, 24) 22 (14, 24) 22 (14, 24) 22 (14, 24) 22 (14, 24) 22 (14, 24) 22 (14, 24) 22 (14, 24) 22 (14, 24) 22 (14, 24) 22 (14, 24) 22 (14, 24)
PI3K+ TC1 n 7 (5, 13) 3 (0, 7) 14 (3, 21) 10 (4, 11) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 2) 2 (0, 3) 0 (0, 0) 4 (3, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.76 (0.67, 0.83) 0.7 (0.6, 0.78) 0.75 (0.63, 0.84) 0.71 (0.59, 0.9) NA (NA, NA) NA (NA, NA) 0.57 (0.54, 0.59) 0.55 (0.55, 0.55) NA (NA, NA) 0.62 (0.58, 0.66) NA (NA, NA) 0.7 (0.56, 0.71) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 r_prob 0.22 (0.22, 0.22) 0.22 (0.22, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.14 (0.14, 0.14) 0.14 (0.14, 0.14) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.092 (0.052, 0.105) 0.063 (0.061, 0.084) 0.072 (0.055, 0.103) 0.097 (0.061, 0.129) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.15 (0.099, 0.201) 0.114 (0.109, 0.119) 0.065 (0.033, 0.757) NA (NA, NA) 0.085 (0.081, 0.114) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
PI3K+ TC2 time 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18) 14 (12, 18)
PI3K+ TC2 n 5 (1, 7) 2 (0, 3) 4 (4, 7) 5 (3, 6) 0 (0, 1) 1 (0, 3) 0 (0, 2) 0 (0, 0) 0 (0, 2) 3 (1, 4) 0 (0, 0) 4 (2, 7) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1)
PI3K+ TC2 post_p 0.72 (0.61, 0.76) 0.58 (0.56, 0.6) 0.66 (0.54, 0.86) 0.6 (0.56, 0.75) NA (NA, NA) 0.54 (0.52, 0.55) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.54 (0.53, 0.56) NA (NA, NA) 0.57 (0.54, 0.75) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.046 (0.01, 0.084) 0.066 (0.055, 0.071) 0.047 (0.037, 0.097) 0.061 (0.019, 0.153) 0 (0, 0) 0 (0, 0.118) 0.336 (0.067, 0.606) NA (NA, NA) 0 (0, 0) 0 (0, 0.052) NA (NA, NA) 0.076 (0.044, 0.111) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 count 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9
PI3K+ TC3 time 15 (14, 19) 15 (14, 19) 15 (14, 19) 15 (14, 19) 15 (14, 19) 15 (14, 19) 15 (14, 19) 15 (14, 19) 15 (14, 19) 15 (14, 19) 15 (14, 19) 15 (14, 19) 15 (14, 19) 15 (14, 19) 15 (14, 19) 15 (14, 19)
PI3K+ TC3 n 8 (3, 10) 1 (0, 3) 5 (2, 9) 4 (2, 9) 0 (0, 0) 3 (0, 5) 0 (0, 2) 2 (1, 2) 0 (0, 0) 1 (0, 2) 0 (0, 0) 4 (2, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 post_p 0.75 (0.62, 0.84) 0.56 (0.51, 0.77) 0.69 (0.55, 0.76) 0.71 (0.59, 0.82) NA (NA, NA) 0.62 (0.53, 0.76) 0.63 (0.54, 0.64) 0.55 (0.51, 0.57) 0.58 (0.58, 0.58) 0.56 (0.56, 0.56) NA (NA, NA) 0.67 (0.55, 0.85) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.065 (0.052, 0.076) 0 (0, 0.142) 0.071 (0.036, 0.124) 0.052 (0.016, 0.071) NA (NA, NA) 0.029 (0, 0.047) 0 (0, 0.062) 0 (0, 0.059) 0.092 (0.092, 0.092) 0.101 (0, 0.238) NA (NA, NA) 0.061 (0, 0.078) 0.212 (0.212, 0.212) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 count 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12
PI3K+ TC4 time 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22) 16 (13, 22)
PI3K+ TC4 n 6 (3, 14) 2 (0, 4) 6 (3, 9) 3 (2, 6) 0 (0, 0) 1 (0, 3) 0 (0, 1) 2 (0, 3) 0 (0, 2) 2 (0, 3) 0 (0, 0) 3 (1, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC4 post_p 0.72 (0.53, 0.86) 0.62 (0.51, 0.82) 0.78 (0.7, 0.89) 0.71 (0.51, 0.78) NA (NA, NA) 0.56 (0.51, 0.68) 0.56 (0.54, 0.6) 0.59 (0.54, 0.69) 0.57 (0.57, 0.57) 0.6 (0.56, 0.61) NA (NA, NA) 0.56 (0.5, 0.73) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.069 (0.019, 0.11) 0.067 (0, 0.09) 0.053 (0.031, 0.068) 0.071 (0, 0.16) NA (NA, NA) 0 (0, 0.079) 0 (0, 0) 0 (0, 0.078) 0.155 (0, 6.301) 0.056 (0, 0.233) NA (NA, NA) 0.073 (0, 0.124) NA (NA, NA) NA (NA, NA) 0.124 (0.124, 0.124) NA (NA, NA)
PI3K+ TC5 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
PI3K+ TC5 time 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17)
PI3K+ TC5 n 12 (9, 16) 6 (4, 8) 6 (4, 7) 5 (5, 5) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 1 (1, 1) 0 (0, 1) 0 (0, 0) 4 (4, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 post_p 0.77 (0.74, 0.8) 0.7 (0.65, 0.75) 0.64 (0.58, 0.7) 0.66 (0.59, 0.72) NA (NA, NA) 0.6 (0.6, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.66 (0.65, 0.68) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 r_prob 0.38 (0.38, 0.38) 0.38 (0.38, 0.38) 0.33 (0.33, 0.33) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 rate 0.072 (0.044, 0.1) 0.087 (0.06, 0.114) 0.074 (0.055, 0.094) 0.113 (0.063, 0.163) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.155 (0.113, 0.198) 0.169 (0.169, 0.169) NA (NA, NA) 0.088 (0.082, 0.093) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Futility:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
all TC1 time 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7)
all TC1 n 17 (12, 22) 3 (2, 5) 2 (1, 2) 1 (1, 3) 3 (2, 6) 1 (1, 4) 0 (0, 1) 1 (0, 3) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.33 (0.17, 0.41) 0.45 (0.45, 0.47) 0.45 (0.44, 0.48) 0.43 (0.36, 0.44) 0.4 (0.32, 0.49) 0.39 (0.37, 0.47) 0.46 (0.44, 0.49) 0.48 (0.47, 0.48) 0.48 (0.48, 0.48) NA (NA, NA) 0.42 (0.42, 0.42) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.48 (0.47, 0.49) 0.42 (0.42, 0.42) NA (NA, NA) 0.46 (0.46, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.39 (0.36, 0.42) 0.46 (0.42, 0.49) 0.49 (0.49, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.153 (0.103, 0.209) 0.147 (0.055, 0.205) 0.203 (0, 1.074) 0.286 (0, 0.972) 0.348 (0.176, 0.48) 0.224 (0.052, 1.218) 0.856 (0.171, 1.541) 0.152 (0.031, 0.224) 0 (0, 0) NA (NA, NA) 0.541 (0.417, 0.664) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.292 (0.058, 0.408) NA (NA, NA) 1.692 (0.338, 3.046) 0.364 (0.364, 0.364) 0 (0, 0) NA (NA, NA) 3.072 (1.696, 4.449) 0.13 (0.026, 0.234) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
all TC2 time 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5)
all TC2 n 7 (6, 9) 1 (0, 2) 0 (0, 1) 0 (0, 0) 3 (1, 3) 1 (0, 3) 1 (0, 2) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (1, 2) 0 (0, 0) 2 (1, 2) 0 (0, 2) 0 (0, 0) 0 (0, 0) 5 (4, 7) 1 (0, 3) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.41 (0.33, 0.47) 0.45 (0.41, 0.49) NA (NA, NA) NA (NA, NA) 0.47 (0.45, 0.48) 0.38 (0.38, 0.38) 0.44 (0.44, 0.44) 0.38 (0.38, 0.38) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.4 (0.38, 0.42) NA (NA, NA) 0.49 (0.49, 0.5) 0.42 (0.42, 0.42) NA (NA, NA) NA (NA, NA) 0.43 (0.39, 0.46) 0.47 (0.46, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.223 (0.101, 0.325) 0.134 (0.027, 0.241) 0 (0, 0) NA (NA, NA) 0.382 (0.076, 0.688) 0.139 (0.028, 0.25) 0.354 (0.336, 0.372) 0.833 (0.833, 0.833) 2.831 (2.831, 2.831) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.231 (0.046, 0.985) NA (NA, NA) 0 (0, 0.146) 0.454 (0.454, 0.454) NA (NA, NA) NA (NA, NA) 0.307 (0.113, 0.328) 0.101 (0.02, 0.181) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC5 time 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11) 10 (10, 11)
all TC5 n 12 (6, 15) 6 (5, 11) 3 (2, 4) 4 (2, 6) 2 (1, 4) 4 (3, 4) 0 (0, 1) 6 (3, 6) 2 (2, 4) 0 (0, 0) 1 (0, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 2 (0, 3) 2 (1, 4) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 post_p 0.26 (0.15, 0.36) 0.35 (0.33, 0.45) 0.45 (0.43, 0.46) 0.35 (0.23, 0.42) 0.37 (0.35, 0.42) 0.37 (0.28, 0.43) 0.44 (0.44, 0.44) 0.33 (0.18, 0.44) 0.4 (0.28, 0.45) NA (NA, NA) 0.47 (0.45, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.46 (0.46, 0.46) 0.48 (0.48, 0.48) NA (NA, NA) 0.43 (0.43, 0.43) NA (NA, NA) NA (NA, NA) 0.48 (0.38, 0.49) 0.43 (0.4, 0.47) 0.36 (0.36, 0.36) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 rate 0.159 (0.143, 0.185) 0.21 (0.155, 0.258) 0.215 (0.054, 0.293) 0.155 (0.143, 0.6) 1.283 (0.273, 2.301) 0.249 (0.11, 0.865) 2.555 (2.555, 2.555) 0.245 (0.148, 0.269) 0.172 (0.131, 0.214) NA (NA, NA) 0.187 (0.113, 0.26) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.133 (0.133, 0.133) 0 (0, 0) NA (NA, NA) 0.975 (0.862, 1.089) NA (NA, NA) NA (NA, NA) 0.136 (0.122, 0.878) 0.203 (0.1, 0.471) 0.17 (0.17, 0.17) NA (NA, NA) 0.28 (0.056, 0.505) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 131 131 131 131 131 131 131 131
AR- & TP53- TC1 time 13 (6, 29) 13 (6, 29) 13 (6, 29) 13 (6, 29) 13 (6, 29) 13 (6, 29) 13 (6, 29) 13 (6, 29)
AR- & TP53- TC1 n 24 (16, 47) 5 (2, 13) 1 (0, 3) 2 (0, 6) 3 (0, 7) 0 (0, 0) 2 (0, 5) 0 (0, 3)
AR- & TP53- TC1 post_p 0.32 (0.12, 0.46) 0.39 (0.2, 0.49) 0.43 (0.28, 0.49) 0.4 (0.28, 0.48) 0.39 (0.24, 0.47) NA (NA, NA) 0.41 (0.27, 0.48) 0.4 (0.29, 0.48)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.126 (0.101, 0.163) 0.155 (0.102, 0.51) 0.181 (0, 0.681) 0.195 (0.096, 0.601) 0.147 (0.074, 0.777) 0 (0, 0) 0.169 (0.08, 0.6) 0.202 (0.02, 1.006)
AR- & TP53- TC2 count 103 103 103 103 103 103 103 103
AR- & TP53- TC2 time 18 (11, 33) 18 (11, 33) 18 (11, 33) 18 (11, 33) 18 (11, 33) 18 (11, 33) 18 (11, 33) 18 (11, 33)
AR- & TP53- TC2 n 21 (9, 47) 4 (2, 12) 1 (0, 3) 2 (0, 6) 5 (2, 9) 0 (0, 0) 2 (0, 6) 1 (0, 3)
AR- & TP53- TC2 post_p 0.33 (0.1, 0.47) 0.36 (0.18, 0.47) 0.42 (0.32, 0.48) 0.4 (0.24, 0.48) 0.38 (0.21, 0.46) NA (NA, NA) 0.41 (0.27, 0.49) 0.42 (0.34, 0.48)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.131 (0.106, 0.201) 0.168 (0.116, 0.482) 0.178 (0.063, 0.781) 0.18 (0.11, 0.54) 0.13 (0.076, 0.27) NA (NA, NA) 0.134 (0.072, 0.613) 0.181 (0.067, 1.45)
AR- & TP53- TC3 count 1 1 1 1 1 1 1 1
AR- & TP53- TC3 time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
AR- & TP53- TC3 n 13 (13, 13) 3 (3, 3) 1 (1, 1) 1 (1, 1) 6 (6, 6) 0 (0, 0) 2 (2, 2) 0 (0, 0)
AR- & TP53- TC3 post_p 0.33 (0.33, 0.33) 0.47 (0.47, 0.47) 0.42 (0.42, 0.42) 0.44 (0.44, 0.44) 0.48 (0.48, 0.48) NA (NA, NA) 0.39 (0.39, 0.39) NA (NA, NA)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.167 (0.167, 0.167) 0.096 (0.096, 0.096) 0.241 (0.241, 0.241) 0.28 (0.28, 0.28) 0.05 (0.05, 0.05) NA (NA, NA) 0.104 (0.104, 0.104) NA (NA, NA)
AR- & TP53- TC4 count 2 2 2 2 2 2 2 2
AR- & TP53- TC4 time 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19)
AR- & TP53- TC4 n 14 (13, 15) 5 (3, 7) 2 (0, 4) 2 (2, 3) 8 (5, 11) 0 (0, 0) 4 (1, 8) 1 (0, 2)
AR- & TP53- TC4 post_p 0.25 (0.09, 0.41) 0.23 (0.16, 0.3) 0.42 (0.42, 0.42) 0.34 (0.32, 0.36) 0.39 (0.35, 0.43) NA (NA, NA) 0.46 (0.46, 0.46) 0.44 (0.44, 0.44)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.139 (0.119, 0.158) 0.286 (0.2, 0.371) 0.084 (0.084, 0.084) 0.285 (0.157, 0.413) 0.124 (0.115, 0.133) NA (NA, NA) 0.036 (0.036, 0.036) 0.048 (0.048, 0.048)
AR- & TP53- TC5 count 101 101 101 101 101 101 101 101
AR- & TP53- TC5 time 20 (11, 33) 20 (11, 33) 20 (11, 33) 20 (11, 33) 20 (11, 33) 20 (11, 33) 20 (11, 33) 20 (11, 33)
AR- & TP53- TC5 n 15 (8, 32) 7 (4, 14) 1 (0, 3) 4 (2, 9) 4 (1, 8) 0 (0, 0) 3 (0, 6) 1 (0, 3)
AR- & TP53- TC5 post_p 0.3 (0.1, 0.47) 0.36 (0.18, 0.49) 0.43 (0.35, 0.49) 0.37 (0.19, 0.47) 0.36 (0.16, 0.47) NA (NA, NA) 0.39 (0.19, 0.48) 0.43 (0.33, 0.48)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.138 (0.113, 0.213) 0.15 (0.106, 0.266) 0.184 (0.068, 0.6) 0.162 (0.096, 0.394) 0.153 (0.093, 0.493) NA (NA, NA) 0.151 (0.08, 0.399) 0.147 (0.039, 0.542)
HRD+ TC1 count 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26
HRD+ TC1 time 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35) 32 (28, 35)
HRD+ TC1 n 10 (6, 17) 0 (0, 0) 7 (2, 14) 2 (1, 6) 0 (0, 0) 2 (0, 3) 0 (0, 0) 1 (0, 3) 3 (2, 6) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.28 (0.16, 0.45) NA (NA, NA) 0.37 (0.17, 0.46) 0.4 (0.33, 0.45) NA (NA, NA) 0.43 (0.37, 0.47) NA (NA, NA) 0.4 (0.34, 0.49) 0.29 (0.19, 0.48) NA (NA, NA) 0.45 (0.38, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.123 (0.087, 0.15) NA (NA, NA) 0.123 (0.087, 0.289) 0.137 (0.088, 0.414) 0.168 (0.168, 0.168) 0.19 (0.086, 0.71) 0.136 (0.136, 0.136) 0.193 (0.074, 0.713) 0.18 (0.092, 0.26) 0.436 (0.436, 0.436) 0.259 (0.104, 0.955) 0.319 (0.064, 0.574) 0.452 (0, 1.745) 0.108 (0.083, 0.134) 0.241 (0.241, 0.241) 0.333 (0.333, 0.333)
HRD+ TC2 count 31 31 31 31 31 31 31 31 31 31 31 31 31 31 31 31
HRD+ TC2 time 34 (26, 36) 34 (26, 36) 34 (26, 36) 34 (26, 36) 34 (26, 36) 34 (26, 36) 34 (26, 36) 34 (26, 36) 34 (26, 36) 34 (26, 36) 34 (26, 36) 34 (26, 36) 34 (26, 36) 34 (26, 36) 34 (26, 36) 34 (26, 36)
HRD+ TC2 n 11 (6, 13) 0 (0, 0) 6 (2, 8) 3 (1, 5) 0 (0, 0) 2 (0, 4) 0 (0, 0) 1 (0, 3) 4 (2, 7) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.28 (0.14, 0.47) NA (NA, NA) 0.34 (0.2, 0.47) 0.38 (0.29, 0.46) NA (NA, NA) 0.42 (0.38, 0.48) 0.46 (0.44, 0.49) 0.43 (0.3, 0.48) 0.33 (0.21, 0.45) NA (NA, NA) 0.45 (0.42, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.117 (0.092, 0.174) 0.3 (0.214, 0.387) 0.127 (0.08, 0.213) 0.135 (0.077, 0.324) 0.92 (0.92, 0.92) 0.132 (0.072, 0.318) 0.346 (0.185, 0.745) 0.224 (0.099, 1.191) 0.138 (0.093, 0.474) NA (NA, NA) 0.2 (0.076, 0.381) 0.279 (0.043, 0.591) 0 (0, 0.209) 0.089 (0.089, 0.089) NA (NA, NA) NA (NA, NA)
HRD+ TC5 count 34 34 34 34 34 34 34 34 34 34 34 34 34 34 34 34
HRD+ TC5 time 32 (25, 36) 32 (25, 36) 32 (25, 36) 32 (25, 36) 32 (25, 36) 32 (25, 36) 32 (25, 36) 32 (25, 36) 32 (25, 36) 32 (25, 36) 32 (25, 36) 32 (25, 36) 32 (25, 36) 32 (25, 36) 32 (25, 36) 32 (25, 36)
HRD+ TC5 n 10 (5, 15) 0 (0, 0) 6 (3, 9) 3 (0, 6) 0 (0, 0) 2 (0, 3) 0 (0, 0) 1 (0, 4) 3 (1, 6) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 post_p 0.27 (0.11, 0.42) NA (NA, NA) 0.33 (0.2, 0.47) 0.4 (0.28, 0.47) NA (NA, NA) 0.42 (0.29, 0.48) NA (NA, NA) 0.41 (0.32, 0.44) 0.35 (0.24, 0.48) NA (NA, NA) 0.44 (0.41, 0.45) NA (NA, NA) 0.44 (0.44, 0.44) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 rate 0.131 (0.088, 0.236) 0.187 (0.158, 0.217) 0.147 (0.078, 0.263) 0.123 (0.077, 0.254) 0.044 (0.009, 0.08) 0.198 (0.099, 0.385) 0 (0, 0) 0.238 (0.094, 0.625) 0.168 (0.095, 0.275) 0.298 (0.298, 0.298) 0.275 (0.057, 3.804) 0.276 (0.055, 0.497) 0.073 (0, 0.29) 1.358 (1.358, 1.358) 0.834 (0.834, 0.834) NA (NA, NA)
TP53+ TC1 count 40 40 40 40 40 40 40 40 40 40 40 40 40 40 40 40
TP53+ TC1 time 20 (15, 33) 20 (15, 33) 20 (15, 33) 20 (15, 33) 20 (15, 33) 20 (15, 33) 20 (15, 33) 20 (15, 33) 20 (15, 33) 20 (15, 33) 20 (15, 33) 20 (15, 33) 20 (15, 33) 20 (15, 33) 20 (15, 33) 20 (15, 33)
TP53+ TC1 n 8 (4, 13) 6 (3, 12) 2 (1, 4) 5 (2, 9) 0 (0, 0) 1 (0, 2) 0 (0, 0) 1 (0, 2) 0 (0, 1) 0 (0, 0) 6 (3, 10) 3 (1, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.35 (0.22, 0.46) 0.38 (0.16, 0.49) 0.42 (0.3, 0.49) 0.34 (0.15, 0.46) NA (NA, NA) 0.43 (0.36, 0.49) NA (NA, NA) 0.44 (0.37, 0.5) 0.42 (0.34, 0.48) NA (NA, NA) 0.36 (0.21, 0.48) 0.35 (0.21, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.159 (0.108, 0.245) 0.165 (0.103, 0.27) 0.208 (0.099, 1.057) 0.168 (0.115, 0.469) 0.086 (0.017, 0.155) 0.144 (0.012, 0.576) NA (NA, NA) 0.147 (0.005, 2.408) 0.124 (0, 0.851) 0.352 (0.352, 0.352) 0.151 (0.105, 0.302) 0.201 (0.133, 0.865) 0 (0, 0) 0.989 (0.403, 1.576) NA (NA, NA) NA (NA, NA)
TP53+ TC2 count 41 41 41 41 41 41 41 41 41 41 41 41 41 41 41 41
TP53+ TC2 time 21 (14, 30) 21 (14, 30) 21 (14, 30) 21 (14, 30) 21 (14, 30) 21 (14, 30) 21 (14, 30) 21 (14, 30) 21 (14, 30) 21 (14, 30) 21 (14, 30) 21 (14, 30) 21 (14, 30) 21 (14, 30) 21 (14, 30) 21 (14, 30)
TP53+ TC2 n 6 (3, 12) 5 (2, 10) 3 (1, 5) 4 (2, 10) 0 (0, 0) 1 (0, 2) 0 (0, 0) 1 (0, 2) 0 (0, 2) 0 (0, 0) 6 (3, 11) 4 (2, 10) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.37 (0.13, 0.49) 0.32 (0.19, 0.45) 0.38 (0.26, 0.47) 0.38 (0.17, 0.47) NA (NA, NA) 0.43 (0.36, 0.48) NA (NA, NA) 0.46 (0.4, 0.5) 0.44 (0.34, 0.48) NA (NA, NA) 0.38 (0.16, 0.48) 0.38 (0.22, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.157 (0.111, 0.55) 0.162 (0.103, 0.498) 0.173 (0.116, 0.491) 0.178 (0.112, 0.358) NA (NA, NA) 0.167 (0.052, 2.27) 0.225 (0.107, 0.343) 0.173 (0.005, 1.163) 0.261 (0, 2.481) 1.24 (1.24, 1.24) 0.147 (0.106, 0.417) 0.159 (0.108, 0.403) 0.144 (0.029, 1.452) 0 (0, 0) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13
TP53+ TC3 time 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33) 21 (17, 33)
TP53+ TC3 n 6 (3, 11) 4 (2, 9) 2 (1, 4) 4 (2, 6) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 5 (3, 8) 4 (1, 7) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.25 (0.16, 0.43) 0.26 (0.15, 0.47) 0.39 (0.32, 0.49) 0.41 (0.27, 0.45) NA (NA, NA) 0.45 (0.44, 0.48) NA (NA, NA) 0.48 (0.41, 0.49) 0.41 (0.38, 0.44) NA (NA, NA) 0.36 (0.21, 0.46) 0.38 (0.27, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.173 (0.12, 0.25) 0.188 (0.125, 0.429) 0.193 (0.011, 0.624) 0.198 (0.109, 0.28) 0 (0, 0) 0.179 (0.039, 1.288) NA (NA, NA) 0.245 (0.038, 0.796) 0.117 (0.045, 0.64) 0.081 (0.081, 0.081) 0.174 (0.138, 0.331) 0.16 (0.116, 0.424) 0 (0, 0.117) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 count 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21
TP53+ TC4 time 24 (19, 32) 24 (19, 32) 24 (19, 32) 24 (19, 32) 24 (19, 32) 24 (19, 32) 24 (19, 32) 24 (19, 32) 24 (19, 32) 24 (19, 32) 24 (19, 32) 24 (19, 32) 24 (19, 32) 24 (19, 32) 24 (19, 32) 24 (19, 32)
TP53+ TC4 n 6 (4, 8) 5 (3, 8) 3 (1, 5) 5 (2, 7) 0 (0, 0) 0 (0, 1) 0 (0, 0) 1 (0, 2) 1 (0, 1) 0 (0, 0) 5 (3, 10) 5 (2, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.35 (0.25, 0.48) 0.36 (0.14, 0.45) 0.43 (0.25, 0.49) 0.35 (0.21, 0.48) NA (NA, NA) 0.46 (0.41, 0.48) NA (NA, NA) 0.44 (0.42, 0.49) 0.44 (0.42, 0.47) NA (NA, NA) 0.32 (0.12, 0.41) 0.37 (0.21, 0.49) 0.47 (0.47, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.142 (0.104, 0.206) 0.211 (0.112, 0.636) 0.178 (0.107, 0.36) 0.203 (0.113, 0.321) NA (NA, NA) 0.088 (0.026, 0.229) NA (NA, NA) 0.077 (0, 0.284) 0.232 (0, 0.618) NA (NA, NA) 0.185 (0.126, 0.364) 0.157 (0.115, 0.26) 0 (0, 0.131) 0.193 (0.193, 0.193) NA (NA, NA) 0 (0, 0)
TP53+ TC5 count 38 38 38 38 38 38 38 38 38 38 38 38 38 38 38 38
TP53+ TC5 time 24 (13, 32) 24 (13, 32) 24 (13, 32) 24 (13, 32) 24 (13, 32) 24 (13, 32) 24 (13, 32) 24 (13, 32) 24 (13, 32) 24 (13, 32) 24 (13, 32) 24 (13, 32) 24 (13, 32) 24 (13, 32) 24 (13, 32) 24 (13, 32)
TP53+ TC5 n 6 (4, 11) 6 (4, 12) 1 (0, 3) 6 (4, 11) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 4 (1, 8) 5 (3, 9) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 post_p 0.36 (0.14, 0.47) 0.35 (0.21, 0.46) 0.4 (0.24, 0.45) 0.33 (0.16, 0.47) NA (NA, NA) 0.44 (0.39, 0.49) NA (NA, NA) 0.45 (0.38, 0.5) 0.48 (0.44, 0.49) 0.5 (0.5, 0.5) 0.34 (0.21, 0.47) 0.42 (0.21, 0.49) NA (NA, NA) NA (NA, NA) 0.43 (0.43, 0.43) NA (NA, NA)
TP53+ TC5 r_prob 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 rate 0.161 (0.109, 0.265) 0.153 (0.119, 0.26) 0.19 (0.111, 0.989) 0.152 (0.119, 0.288) NA (NA, NA) 0.108 (0, 0.747) 0.204 (0.204, 0.204) 0.106 (0, 1.791) 0.192 (0, 0.807) 0.148 (0.03, 0.267) 0.204 (0.128, 0.596) 0.151 (0.092, 0.411) 0.193 (0.193, 0.193) 0.096 (0.096, 0.096) 1.324 (1.25, 1.398) NA (NA, NA)
TEfus+ TC1 count 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16
TEfus+ TC1 time 22 (19, 32) 22 (19, 32) 22 (19, 32) 22 (19, 32) 22 (19, 32) 22 (19, 32) 22 (19, 32) 22 (19, 32) 22 (19, 32) 22 (19, 32) 22 (19, 32) 22 (19, 32) 22 (19, 32) 22 (19, 32) 22 (19, 32) 22 (19, 32)
TEfus+ TC1 n 2 (0, 4) 3 (1, 6) 2 (1, 4) 4 (2, 9) 3 (0, 6) 1 (0, 2) 0 (0, 0) 0 (0, 2) 2 (0, 4) 2 (1, 4) 5 (4, 10) 4 (1, 7) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.41 (0.33, 0.48) 0.38 (0.28, 0.47) 0.42 (0.33, 0.48) 0.34 (0.26, 0.45) 0.4 (0.2, 0.49) 0.4 (0.32, 0.43) NA (NA, NA) 0.45 (0.36, 0.46) 0.37 (0.24, 0.48) 0.46 (0.37, 0.49) 0.42 (0.3, 0.48) 0.31 (0.2, 0.41) 0.44 (0.44, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.2 (0.099, 1.139) 0.195 (0.098, 2.167) 0.158 (0.115, 0.488) 0.157 (0.114, 0.321) 0.119 (0.08, 0.44) 0.289 (0.155, 0.6) NA (NA, NA) 0.193 (0.094, 3.404) 0.192 (0.082, 0.549) 0.139 (0.095, 0.493) 0.125 (0.085, 0.2) 0.212 (0.141, 1.061) 0.407 (0, 2.385) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 count 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18
TEfus+ TC2 time 17 (14, 26) 17 (14, 26) 17 (14, 26) 17 (14, 26) 17 (14, 26) 17 (14, 26) 17 (14, 26) 17 (14, 26) 17 (14, 26) 17 (14, 26) 17 (14, 26) 17 (14, 26) 17 (14, 26) 17 (14, 26) 17 (14, 26) 17 (14, 26)
TEfus+ TC2 n 1 (0, 2) 2 (1, 5) 2 (1, 5) 4 (2, 7) 3 (1, 5) 0 (0, 2) 0 (0, 0) 0 (0, 1) 2 (1, 5) 1 (0, 3) 6 (5, 11) 6 (3, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.42 (0.39, 0.5) 0.43 (0.19, 0.48) 0.41 (0.22, 0.46) 0.43 (0.2, 0.49) 0.38 (0.27, 0.48) 0.32 (0.28, 0.34) NA (NA, NA) 0.42 (0.36, 0.43) 0.43 (0.3, 0.45) 0.44 (0.4, 0.48) 0.38 (0.22, 0.5) 0.4 (0.13, 0.48) 0.4 (0.4, 0.4) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.223 (0.01, 0.309) 0.166 (0.098, 0.654) 0.159 (0.095, 1.127) 0.137 (0.086, 0.418) 0.141 (0.051, 0.394) 0.143 (0, 0.859) 0.372 (0.372, 0.372) 0.23 (0.071, 0.448) 0.174 (0.121, 0.416) 0.192 (0.124, 0.904) 0.128 (0.087, 0.183) 0.151 (0.103, 0.418) 0.502 (0.048, 1.067) 0 (0, 0) NA (NA, NA) 0.284 (0.284, 0.284)
TEfus+ TC3 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TEfus+ TC3 time 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15)
TEfus+ TC3 n 3 (3, 3) 1 (1, 1) 0 (0, 0) 3 (3, 3) 4 (4, 4) 3 (3, 3) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 5 (5, 5) 4 (4, 4) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.35 (0.35, 0.35) 0.35 (0.35, 0.35) NA (NA, NA) 0.32 (0.32, 0.32) 0.5 (0.5, 0.5) 0.49 (0.49, 0.49) NA (NA, NA) NA (NA, NA) 0.4 (0.4, 0.4) NA (NA, NA) 0.44 (0.44, 0.44) 0.34 (0.34, 0.34) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.211 (0.211, 0.211) 0.492 (0.492, 0.492) NA (NA, NA) 0.262 (0.262, 0.262) 0.069 (0.069, 0.069) 0.109 (0.109, 0.109) NA (NA, NA) NA (NA, NA) 0.301 (0.301, 0.301) NA (NA, NA) 0.179 (0.179, 0.179) 0.173 (0.173, 0.173) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TEfus+ TC4 time 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25) 25 (25, 25)
TEfus+ TC4 n 2 (2, 2) 3 (3, 3) 2 (2, 2) 15 (15, 15) 5 (5, 5) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 6 (6, 6) 4 (4, 4) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.32 (0.32, 0.32) 0.28 (0.28, 0.28) 0.43 (0.43, 0.43) 0.39 (0.39, 0.39) 0.3 (0.3, 0.3) 0.43 (0.43, 0.43) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.41 (0.41, 0.41) 0.36 (0.36, 0.36) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.54 (0.54, 0.54) 0.232 (0.232, 0.232) 0.148 (0.148, 0.148) 0.123 (0.123, 0.123) 0.111 (0.111, 0.111) 0.102 (0.102, 0.102) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.159 (0.159, 0.159) 0.217 (0.217, 0.217) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 count 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15
TEfus+ TC5 time 19 (12, 28) 19 (12, 28) 19 (12, 28) 19 (12, 28) 19 (12, 28) 19 (12, 28) 19 (12, 28) 19 (12, 28) 19 (12, 28) 19 (12, 28) 19 (12, 28) 19 (12, 28) 19 (12, 28) 19 (12, 28) 19 (12, 28) 19 (12, 28)
TEfus+ TC5 n 1 (0, 4) 4 (1, 7) 1 (0, 4) 6 (3, 9) 3 (0, 5) 1 (0, 3) 0 (0, 0) 1 (0, 2) 2 (0, 4) 2 (0, 3) 4 (2, 6) 5 (2, 9) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 post_p 0.41 (0.36, 0.49) 0.39 (0.19, 0.45) 0.41 (0.31, 0.49) 0.31 (0.21, 0.46) 0.33 (0.16, 0.42) 0.4 (0.3, 0.45) NA (NA, NA) 0.45 (0.42, 0.46) 0.38 (0.19, 0.45) 0.44 (0.4, 0.48) 0.36 (0.22, 0.47) 0.38 (0.22, 0.45) 0.46 (0.46, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 rate 0.297 (0, 0.737) 0.158 (0.109, 0.37) 0.202 (0.087, 0.389) 0.177 (0.118, 0.305) 0.186 (0.077, 0.753) 0.21 (0.155, 0.467) NA (NA, NA) 0.158 (0.092, 0.87) 0.18 (0.091, 0.302) 0.205 (0.08, 0.791) 0.161 (0.121, 0.42) 0.14 (0.089, 0.245) 0.136 (0.034, 0.232) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 count 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28 28
PI3K+ TC1 time 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32) 24 (16, 32)
PI3K+ TC1 n 6 (3, 13) 4 (1, 7) 6 (3, 10) 5 (2, 11) 0 (0, 0) 1 (0, 3) 1 (0, 2) 1 (0, 3) 1 (0, 2) 1 (0, 3) 0 (0, 0) 3 (1, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.31 (0.18, 0.45) 0.38 (0.23, 0.45) 0.36 (0.19, 0.47) 0.36 (0.17, 0.45) NA (NA, NA) 0.43 (0.33, 0.47) 0.44 (0.41, 0.47) 0.42 (0.36, 0.47) 0.47 (0.36, 0.49) 0.4 (0.27, 0.46) NA (NA, NA) 0.32 (0.18, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 r_prob 0.22 (0.22, 0.22) 0.22 (0.22, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.14 (0.14, 0.14) 0.14 (0.14, 0.14) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.169 (0.112, 0.405) 0.157 (0.097, 0.326) 0.165 (0.107, 0.293) 0.159 (0.108, 0.354) 0.136 (0.136, 0.136) 0.233 (0.089, 0.438) 0.169 (0.057, 0.756) 0.172 (0.024, 0.96) 0.14 (0.031, 0.521) 0.288 (0.016, 0.948) 0.558 (0.558, 0.558) 0.235 (0.112, 0.792) NA (NA, NA) 0 (0, 0) 0.181 (0.181, 0.181) 0.29 (0.29, 0.29)
PI3K+ TC2 count 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30
PI3K+ TC2 time 20 (17, 30) 20 (17, 30) 20 (17, 30) 20 (17, 30) 20 (17, 30) 20 (17, 30) 20 (17, 30) 20 (17, 30) 20 (17, 30) 20 (17, 30) 20 (17, 30) 20 (17, 30) 20 (17, 30) 20 (17, 30) 20 (17, 30) 20 (17, 30)
PI3K+ TC2 n 6 (2, 11) 3 (0, 7) 7 (3, 10) 4 (2, 9) 0 (0, 0) 1 (0, 4) 1 (0, 3) 0 (0, 2) 1 (0, 2) 1 (0, 2) 0 (0, 0) 4 (3, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 post_p 0.38 (0.16, 0.49) 0.37 (0.23, 0.44) 0.33 (0.19, 0.42) 0.34 (0.22, 0.41) NA (NA, NA) 0.38 (0.3, 0.46) 0.42 (0.36, 0.47) 0.44 (0.35, 0.5) 0.42 (0.42, 0.46) 0.45 (0.32, 0.49) NA (NA, NA) 0.34 (0.24, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.163 (0.106, 0.258) 0.175 (0.118, 0.373) 0.168 (0.127, 0.355) 0.152 (0.117, 0.34) 0 (0, 0) 0.159 (0.047, 0.558) 0.22 (0.079, 0.632) 0.23 (0.088, 0.469) 0.193 (0, 0.514) 0.17 (0.016, 0.358) 0.62 (0.124, 1.116) 0.148 (0.089, 0.248) 0 (0, 0) 0.373 (0.191, 0.556) 0 (0, 0) 0.584 (0.117, 1.052)
PI3K+ TC3 count 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8
PI3K+ TC3 time 18 (15, 26) 18 (15, 26) 18 (15, 26) 18 (15, 26) 18 (15, 26) 18 (15, 26) 18 (15, 26) 18 (15, 26) 18 (15, 26) 18 (15, 26) 18 (15, 26) 18 (15, 26) 18 (15, 26) 18 (15, 26) 18 (15, 26) 18 (15, 26)
PI3K+ TC3 n 8 (5, 12) 2 (2, 4) 4 (2, 6) 4 (2, 5) 0 (0, 0) 2 (1, 2) 0 (0, 1) 1 (1, 2) 0 (0, 2) 0 (0, 3) 0 (0, 0) 5 (2, 9) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 post_p 0.35 (0.2, 0.42) 0.35 (0.19, 0.45) 0.24 (0.12, 0.39) 0.34 (0.25, 0.47) NA (NA, NA) 0.46 (0.46, 0.48) 0.49 (0.49, 0.49) 0.44 (0.4, 0.49) 0.47 (0.45, 0.49) 0.47 (0.47, 0.47) NA (NA, NA) 0.38 (0.26, 0.48) 0.47 (0.47, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.16 (0.125, 0.238) 0.304 (0.142, 0.669) 0.211 (0.161, 0.897) 0.188 (0.119, 0.306) NA (NA, NA) 0.062 (0, 0.769) 0.032 (0, 0.387) 0.159 (0.056, 0.33) 0.199 (0.04, 0.261) 0.289 (0.143, 0.514) NA (NA, NA) 0.169 (0.105, 0.262) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 count 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9
PI3K+ TC4 time 26 (22, 32) 26 (22, 32) 26 (22, 32) 26 (22, 32) 26 (22, 32) 26 (22, 32) 26 (22, 32) 26 (22, 32) 26 (22, 32) 26 (22, 32) 26 (22, 32) 26 (22, 32) 26 (22, 32) 26 (22, 32) 26 (22, 32) 26 (22, 32)
PI3K+ TC4 n 7 (5, 22) 4 (3, 8) 6 (4, 10) 5 (2, 10) 0 (0, 0) 1 (0, 2) 0 (0, 1) 1 (0, 1) 1 (0, 1) 0 (0, 1) 0 (0, 0) 3 (2, 7) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0)
PI3K+ TC4 post_p 0.34 (0.28, 0.44) 0.34 (0.24, 0.44) 0.38 (0.1, 0.45) 0.4 (0.28, 0.45) NA (NA, NA) 0.43 (0.37, 0.48) 0.44 (0.42, 0.46) 0.44 (0.4, 0.48) 0.44 (0.42, 0.44) 0.45 (0.36, 0.49) NA (NA, NA) 0.4 (0.31, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.126 (0.114, 0.203) 0.181 (0.122, 0.288) 0.161 (0.128, 0.348) 0.199 (0.12, 0.379) NA (NA, NA) 0.102 (0.069, 0.306) 0.042 (0.008, 0.21) 0.124 (0.014, 0.333) 0.629 (0.492, 0.868) 0.216 (0.143, 0.257) NA (NA, NA) 0.185 (0.13, 0.356) NA (NA, NA) 0 (0, 0) 0.13 (0.079, 0.18) NA (NA, NA)
PI3K+ TC5 count 40 40 40 40 40 40 40 40 40 40 40 40 40 40 40 40
PI3K+ TC5 time 20 (9, 30) 20 (9, 30) 20 (9, 30) 20 (9, 30) 20 (9, 30) 20 (9, 30) 20 (9, 30) 20 (9, 30) 20 (9, 30) 20 (9, 30) 20 (9, 30) 20 (9, 30) 20 (9, 30) 20 (9, 30) 20 (9, 30) 20 (9, 30)
PI3K+ TC5 n 8 (4, 16) 4 (2, 8) 5 (3, 11) 6 (2, 12) 0 (0, 0) 1 (0, 2) 1 (0, 2) 0 (0, 2) 1 (0, 2) 1 (0, 3) 0 (0, 0) 3 (2, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 post_p 0.4 (0.17, 0.49) 0.39 (0.18, 0.48) 0.38 (0.17, 0.47) 0.34 (0.2, 0.45) NA (NA, NA) 0.43 (0.31, 0.47) 0.45 (0.37, 0.49) 0.4 (0.28, 0.45) 0.46 (0.43, 0.49) 0.45 (0.32, 0.48) NA (NA, NA) 0.36 (0.22, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 r_prob 0.38 (0.38, 0.38) 0.38 (0.38, 0.38) 0.33 (0.33, 0.33) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 rate 0.139 (0.096, 0.292) 0.162 (0.092, 0.394) 0.153 (0.11, 0.327) 0.17 (0.115, 0.375) NA (NA, NA) 0.249 (0.024, 2.254) 0.173 (0, 0.386) 0.198 (0.026, 0.88) 0.121 (0, 0.367) 0.168 (0, 0.828) NA (NA, NA) 0.195 (0.113, 0.7) NA (NA, NA) 0 (0, 0) 0.096 (0.096, 0.096) 0.191 (0.191, 0.191)