Simulation scenario 5, CR phase

Setting description

TC3 and TC4 more effective in the HRD+ biomarker signature

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4	TC5
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.099, shape = 1.05	scale = 0.099, shape = 1.05	scale = 0.112, shape = 1.05
all	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 9.9, median = 7.1	mean = 9.9, median = 7.1	mean = 8.8, median = 6.3
all	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.13, hr = 0.88	af = 1.13, hr = 0.88	af = 1, hr = 1
AR- & TP53-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.096, shape = 1.05	scale = 0.096, shape = 1.05	scale = 0.112, shape = 1.05
AR- & TP53-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 10.2, median = 7.4	mean = 10.2, median = 7.4	mean = 8.8, median = 6.3
AR- & TP53-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.16, hr = 0.85	af = 1.16, hr = 0.85	af = 1, hr = 1
HRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
HRD+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
HRD+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.107, shape = 1.05	scale = 0.107, shape = 1.05	scale = 0.112, shape = 1.05
TP53+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 9.2, median = 6.6	mean = 9.2, median = 6.6	mean = 8.8, median = 6.3
TP53+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.04, hr = 0.96	af = 1.04, hr = 0.96	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.097, shape = 1.05	scale = 0.097, shape = 1.05	scale = 0.112, shape = 1.05
TEfus+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 10.1, median = 7.3	mean = 10.1, median = 7.3	mean = 8.8, median = 6.3
TEfus+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.15, hr = 0.87	af = 1.15, hr = 0.87	af = 1, hr = 1
PI3K+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.104, shape = 1.05	scale = 0.104, shape = 1.05	scale = 0.112, shape = 1.05
PI3K+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 9.4, median = 6.8	mean = 9.4, median = 6.8	mean = 8.8, median = 6.3
PI3K+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.07, hr = 0.93	af = 1.07, hr = 0.93	af = 1, hr = 1

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4	TC5
—–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-+—	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-+—	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
-+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-+–+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-+–+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
-+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-+-+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-+-+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
-+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-+-++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-+-++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
-++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-++–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-++–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
-++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-++-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-++-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
-+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-+++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-+++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
-++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-++++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-++++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
+—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+—-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+—-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+—+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+—+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+–+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+–+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+–++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+–++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
++—	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
++—	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
++–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
++–+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
++–+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
++-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
++-+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
++-+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
++-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
++-++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
++-++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
+++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
+++–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
+++–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
+++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
+++-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
+++-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
++++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
++++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
++++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
+++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
+++++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
+++++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 6 1 14 15 3 AR- & TP53- 20 24 39 50 13 HRD+ 0 1 275 281 0 TP53+ 5 2 7 8 3 TEfus+ 2 2 6 9 2 PI3K+ 5 5 9 12 2

TC1 TC2 TC3 TC4 TC5 all 0.012 0.002 0.028 0.030 0.006 AR- & TP53- 0.040 0.048 0.078 0.100 0.026 HRD+ 0.000 0.002 0.550 0.562 0.000 TP53+ 0.010 0.004 0.014 0.016 0.006 TEfus+ 0.004 0.004 0.012 0.018 0.004 PI3K+ 0.010 0.010 0.018 0.024 0.004

futility (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 7 3 0 0 4 AR- & TP53- 131 103 1 2 101 HRD+ 26 31 0 0 34 TP53+ 40 41 13 21 38 TEfus+ 16 18 1 1 15 PI3K+ 28 30 8 9 40

TC1 TC2 TC3 TC4 TC5 all 0.014 0.006 0.000 0.000 0.008 AR- & TP53- 0.262 0.206 0.002 0.004 0.202 HRD+ 0.052 0.062 0.000 0.000 0.068 TP53+ 0.080 0.082 0.026 0.042 0.076 TEfus+ 0.032 0.036 0.002 0.002 0.030 PI3K+ 0.056 0.060 0.016 0.018 0.080

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 0 0 0 0 0 AR- & TP53- 53 31 41 46 44 HRD+ 0 0 0 0 0 TP53+ 0 0 0 0 0 TEfus+ 0 0 0 0 0 PI3K+ 0 0 0 0 0

TC1 TC2 TC3 TC4 TC5 all 0.000 0.000 0.000 0.000 0.000 AR- & TP53- 0.106 0.062 0.082 0.092 0.088 HRD+ 0.000 0.000 0.000 0.000 0.000 TP53+ 0.000 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.000 0.000 0.000 0.000 PI3K+ 0.000 0.000 0.000 0.000 0.000

Operating characteristics

char	overall	TC1	TC2	TC3	TC4	TC5
err_sign	0.3286573	0.0761523	0.0641283	0.0821643	0.1022044	0.0420842
err_type	0.4228457	0.0761523	0.0641283	0.1382766	0.1663327	0.0420842
pow_sign	0.8036072	0.0000000	0.0000000	0.5511022	0.5631263	0.0000000
pow_type	0.8737475	0.0000000	0.0000000	0.6332665	0.6653307	0.0000000

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4	TC5
all	graduation	0	6	1	14	15	3
all	futility	0	7	3	0	0	4
all	max_n	0	0	0	0	0	0
all	n	366 (335, 406)	160 (100, 225)	160 (108, 219)	163 (112, 217)	159 (110, 217)	165 (105, 224)
all	n_unique	335 (306, 373)	148 (92, 210)	146 (98, 202)	150 (103, 200)	146 (99, 201)	152 (96, 208)
all	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
all	time_stop	NA (NA, NA)	5 (3, 7)	4 (3, 5)	7 (6, 9)	8 (6, 13)	10 (7, 11)
all	post_p	NA (NA, NA)	0.45 (0.07, 0.87)	0.46 (0.09, 0.86)	1 (0.91, 1)	1 (0.92, 1)	0.47 (0.07, 0.87)
all	rate	0.112 (0.104, 0.12)	0.113 (0.1, 0.129)	0.113 (0.102, 0.127)	0.084 (0.073, 0.095)	0.084 (0.072, 0.095)	0.113 (0.102, 0.128)
AR- & TP53-	graduation	0	20	24	39	50	13
AR- & TP53-	futility	0	131	103	1	2	101
AR- & TP53-	max_n	0	53	31	41	46	44
AR- & TP53-	n	217 (191, 251)	87 (29, 150)	77 (31, 139)	89 (47, 143)	88 (45, 146)	85 (33, 146)
AR- & TP53-	n_unique	201 (175, 232)	80 (28, 140)	71 (29, 129)	82 (43, 135)	81 (39, 137)	79 (30, 138)
AR- & TP53-	time_trial	36 (36, 36)	36 (10, 36)	36 (14, 36)	36 (36, 36)	36 (32, 36)	36 (16, 36)
AR- & TP53-	time_stop	NA (NA, NA)	12 (6, 28)	17 (10, 31)	14 (9, 25)	14 (10, 27)	19 (11, 33)
AR- & TP53-	post_p	NA (NA, NA)	0.41 (0.07, 0.85)	0.4 (0.08, 0.87)	1 (0.88, 1)	0.99 (0.87, 1)	0.44 (0.08, 0.87)
AR- & TP53-	rate	0.113 (0.102, 0.123)	0.115 (0.098, 0.14)	0.114 (0.098, 0.14)	0.076 (0.06, 0.093)	0.077 (0.058, 0.093)	0.114 (0.098, 0.14)
HRD+	graduation	0	0	1	275	281	0
HRD+	futility	0	26	31	0	0	34
HRD+	max_n	0	0	0	0	0	0
HRD+	n	60 (48, 72)	21 (10, 35)	23 (13, 35)	34 (25, 56)	32 (25, 54)	22 (14, 35)
HRD+	n_unique	55 (44, 67)	19 (10, 32)	20 (11, 32)	31 (22, 51)	29 (21, 49)	20 (12, 32)
HRD+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	33 (19, 36)	32 (19, 36)	36 (36, 36)
HRD+	time_stop	NA (NA, NA)	32 (28, 35)	34 (26, 36)	23 (17, 33)	24 (17, 32)	32 (25, 36)
HRD+	post_p	NA (NA, NA)	0.31 (0.08, 0.75)	0.32 (0.07, 0.73)	1 (1, 1)	1 (1, 1)	0.32 (0.06, 0.73)
HRD+	rate	0.114 (0.093, 0.137)	0.114 (0.082, 0.165)	0.116 (0.085, 0.156)	0.036 (0.025, 0.047)	0.035 (0.025, 0.047)	0.114 (0.086, 0.161)
TP53+	graduation	0	5	2	7	8	3
TP53+	futility	0	40	41	13	21	38
TP53+	max_n	0	0	0	0	0	0
TP53+	n	122 (106, 139)	58 (34, 79)	63 (41, 82)	56 (35, 77)	55 (34, 75)	61 (37, 81)
TP53+	n_unique	110 (96, 126)	53 (31, 72)	57 (37, 75)	51 (31, 70)	50 (30, 69)	56 (34, 75)
TP53+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
TP53+	time_stop	NA (NA, NA)	20 (15, 33)	20 (14, 30)	20 (15, 29)	22 (17, 30)	23 (12, 31)
TP53+	post_p	NA (NA, NA)	0.46 (0.08, 0.87)	0.48 (0.12, 0.86)	0.64 (0.21, 0.95)	0.68 (0.19, 0.97)	0.46 (0.09, 0.83)
TP53+	rate	0.111 (0.097, 0.128)	0.115 (0.093, 0.141)	0.113 (0.095, 0.138)	0.104 (0.083, 0.128)	0.103 (0.084, 0.13)	0.114 (0.095, 0.14)
TEfus+	graduation	0	2	2	6	9	2
TEfus+	futility	0	16	18	1	1	15
TEfus+	max_n	0	0	0	0	0	0
TEfus+	n	115 (99, 133)	54 (35, 73)	58 (41, 79)	56 (39, 74)	56 (38, 73)	58 (38, 76)
TEfus+	n_unique	104 (89, 119)	48 (31, 66)	52 (37, 72)	52 (34, 67)	51 (33, 66)	53 (35, 69)
TEfus+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
TEfus+	time_stop	NA (NA, NA)	20 (16, 32)	16 (15, 26)	12 (11, 19)	18 (14, 20)	18 (12, 28)
TEfus+	post_p	NA (NA, NA)	0.46 (0.08, 0.85)	0.42 (0.1, 0.87)	0.93 (0.61, 1)	0.93 (0.55, 1)	0.41 (0.1, 0.86)
TEfus+	rate	0.112 (0.098, 0.129)	0.113 (0.093, 0.145)	0.114 (0.096, 0.137)	0.083 (0.067, 0.105)	0.083 (0.065, 0.105)	0.114 (0.095, 0.139)
PI3K+	graduation	0	5	5	9	12	2
PI3K+	futility	0	28	30	8	9	40
PI3K+	max_n	0	0	0	0	0	0
PI3K+	n	121 (104, 136)	54 (32, 79)	56 (35, 78)	54 (34, 75)	53 (33, 75)	64 (42, 88)
PI3K+	n_unique	109 (95, 124)	49 (29, 71)	50 (31, 72)	49 (30, 68)	48 (30, 68)	59 (39, 80)
PI3K+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
PI3K+	time_stop	NA (NA, NA)	24 (15, 31)	19 (15, 30)	17 (15, 24)	21 (14, 31)	19 (9, 30)
PI3K+	post_p	NA (NA, NA)	0.47 (0.11, 0.88)	0.48 (0.1, 0.84)	0.77 (0.37, 0.98)	0.76 (0.33, 0.98)	0.48 (0.1, 0.86)
PI3K+	rate	0.113 (0.099, 0.128)	0.113 (0.092, 0.141)	0.113 (0.095, 0.143)	0.098 (0.077, 0.119)	0.097 (0.078, 0.123)	0.114 (0.097, 0.138)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4	TC5
—–	graduation	0	26	25	52	63	16
—–	futility	0	134	106	1	2	102
—–	max_n	0	53	31	41	46	44
—–	n	125 (104, 150)	45 (18, 103)	36 (12, 95)	36 (11, 86)	38 (10, 94)	39 (11, 98)
—–	n_unique	116 (95, 140)	43 (18, 99)	35 (12, 91)	34 (10, 83)	37 (10, 89)	37 (10, 93)
—–	post_p	NA (NA, NA)	0.45 (0.12, 0.86)	0.41 (0.1, 0.87)	0.42 (0.08, 0.88)	0.44 (0.1, 0.89)	0.43 (0.09, 0.89)
—–	rate	0.113 (0.1, 0.127)	0.116 (0.097, 0.156)	0.117 (0.096, 0.175)	0.119 (0.093, 0.174)	0.116 (0.094, 0.176)	0.117 (0.094, 0.172)
—-+	graduation	0	31	29	60	71	17
—-+	futility	0	146	120	9	11	126
—-+	max_n	0	53	31	41	46	44
—-+	n	30 (22, 39)	10 (3, 26)	10 (3, 25)	10 (3, 23)	10 (3, 23)	13 (5, 28)
—-+	n_unique	27 (20, 36)	9 (3, 24)	9 (2, 23)	9 (2, 21)	9 (3, 21)	12 (4, 26)
—-+	post_p	NA (NA, NA)	0.47 (0.16, 0.85)	0.44 (0.16, 0.84)	0.46 (0.16, 0.84)	0.46 (0.17, 0.84)	0.47 (0.19, 0.86)
—-+	rate	0.114 (0.089, 0.149)	0.123 (0.081, 0.282)	0.125 (0.08, 0.268)	0.122 (0.081, 0.269)	0.121 (0.08, 0.287)	0.12 (0.082, 0.218)
—+-	graduation	0	27	27	55	69	17
—+-	futility	0	141	113	2	3	111
—+-	max_n	0	53	31	41	46	44
—+-	n	5 (2, 8)	3 (0, 6)	2 (0, 6)	3 (0, 6)	2 (0, 5)	2 (0, 5)
—+-	n_unique	4 (2, 7)	2 (0, 5)	2 (0, 5)	2 (0, 5)	2 (0, 5)	2 (0, 5)
—+-	post_p	NA (NA, NA)	0.45 (0.28, 0.72)	0.47 (0.29, 0.75)	0.5 (0.28, 0.74)	0.48 (0.29, 0.74)	0.46 (0.29, 0.76)
—+-	rate	0.114 (0.057, 0.253)	0.135 (0.054, 0.455)	0.134 (0.051, 0.422)	0.127 (0.041, 0.432)	0.128 (0.041, 0.521)	0.14 (0.052, 0.6)
—++	graduation	0	32	31	63	77	18
—++	futility	0	153	126	10	11	131
—++	max_n	0	53	31	41	46	44
—++	n	13 (8, 19)	5 (1, 13)	5 (1, 11)	5 (1, 11)	5 (2, 11)	6 (2, 14)
—++	n_unique	12 (8, 17)	5 (1, 12)	4 (1, 10)	4 (1, 10)	4 (1, 10)	6 (2, 13)
—++	post_p	NA (NA, NA)	0.44 (0.21, 0.81)	0.47 (0.23, 0.81)	0.43 (0.19, 0.8)	0.46 (0.22, 0.8)	0.46 (0.2, 0.82)
—++	rate	0.113 (0.076, 0.172)	0.13 (0.069, 0.384)	0.128 (0.068, 0.34)	0.136 (0.069, 0.436)	0.13 (0.071, 0.354)	0.124 (0.074, 0.306)
–+–	graduation	0	11	3	21	23	6
–+–	futility	0	47	44	13	21	42
–+–	max_n	0	0	0	0	0	0
–+–	n	26 (19, 33)	11 (5, 25)	11 (4, 24)	9 (3, 22)	9 (3, 21)	10 (3, 23)
–+–	n_unique	23 (17, 31)	10 (4, 22)	10 (3, 22)	8 (3, 20)	8 (3, 20)	9 (3, 21)
–+–	post_p	NA (NA, NA)	0.42 (0.15, 0.85)	0.47 (0.16, 0.84)	0.4 (0.16, 0.82)	0.44 (0.17, 0.82)	0.44 (0.16, 0.84)
–+–	rate	0.11 (0.082, 0.152)	0.123 (0.084, 0.242)	0.12 (0.078, 0.274)	0.128 (0.081, 0.259)	0.125 (0.078, 0.251)	0.127 (0.079, 0.284)
–+-+	graduation	0	16	6	29	35	7
–+-+	futility	0	71	68	21	25	64
–+-+	max_n	0	0	0	0	0	0
–+-+	n	25 (18, 32)	10 (3, 21)	10 (3, 22)	9 (3, 21)	8 (3, 19)	12 (4, 24)
–+-+	n_unique	23 (16, 30)	9 (3, 19)	9 (3, 19)	8 (3, 20)	8 (3, 17)	11 (4, 22)
–+-+	post_p	NA (NA, NA)	0.46 (0.18, 0.86)	0.49 (0.16, 0.86)	0.42 (0.16, 0.84)	0.44 (0.17, 0.81)	0.46 (0.15, 0.85)
–+-+	rate	0.115 (0.085, 0.15)	0.122 (0.079, 0.268)	0.122 (0.078, 0.291)	0.129 (0.08, 0.258)	0.127 (0.082, 0.256)	0.123 (0.083, 0.23)
–++-	graduation	0	13	5	26	30	7
–++-	futility	0	59	58	14	21	49
–++-	max_n	0	0	0	0	0	0
–++-	n	7 (3, 11)	3 (1, 7)	4 (1, 8)	3 (1, 7)	3 (1, 7)	3 (1, 7)
–++-	n_unique	6 (3, 10)	3 (1, 6)	4 (1, 8)	3 (1, 6)	3 (1, 6)	3 (1, 6)
–++-	post_p	NA (NA, NA)	0.48 (0.26, 0.78)	0.44 (0.24, 0.75)	0.48 (0.29, 0.78)	0.48 (0.27, 0.76)	0.46 (0.25, 0.77)
–++-	rate	0.113 (0.064, 0.217)	0.125 (0.058, 0.463)	0.129 (0.064, 0.365)	0.12 (0.052, 0.414)	0.127 (0.052, 0.459)	0.136 (0.053, 0.546)
–+++	graduation	0	18	8	34	42	8
–+++	futility	0	79	78	22	25	71
–+++	max_n	0	0	0	0	0	0
–+++	n	19 (14, 26)	8 (3, 16)	8 (3, 18)	7 (2, 17)	7 (2, 16)	9 (4, 19)
–+++	n_unique	17 (12, 24)	7 (2, 15)	7 (3, 16)	6 (2, 15)	6 (2, 15)	9 (4, 17)
–+++	post_p	NA (NA, NA)	0.46 (0.19, 0.83)	0.46 (0.19, 0.86)	0.42 (0.18, 0.81)	0.44 (0.17, 0.8)	0.44 (0.18, 0.79)
–+++	rate	0.111 (0.077, 0.159)	0.124 (0.075, 0.299)	0.123 (0.078, 0.28)	0.13 (0.076, 0.315)	0.126 (0.076, 0.296)	0.125 (0.082, 0.244)
-+—	graduation	0	26	26	290	308	16
-+—	futility	0	154	133	1	2	131
-+—	max_n	0	52	30	38	42	43
-+—	n	27 (19, 35)	5 (1, 16)	7 (2, 15)	15 (8, 28)	14 (7, 27)	6 (2, 15)
-+—	n_unique	25 (17, 33)	5 (1, 14)	6 (2, 14)	14 (7, 26)	12 (6, 25)	6 (2, 13)
-+—	post_p	NA (NA, NA)	0.34 (0.15, 0.66)	0.33 (0.14, 0.64)	0.99 (0.86, 1)	0.98 (0.81, 1)	0.32 (0.14, 0.64)
-+—	rate	0.112 (0.084, 0.155)	0.125 (0.076, 0.36)	0.124 (0.076, 0.261)	0.036 (0.022, 0.055)	0.035 (0.021, 0.058)	0.126 (0.075, 0.3)
-+–+	graduation	0	30	30	294	308	17
-+–+	futility	0	165	143	9	10	154
-+–+	max_n	0	52	30	38	42	43
-+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.53 (0.5, 0.53)	0.56 (0.56, 0.56)	0.49 (0.49, 0.49)
-+–+	rate	0.169 (0, 1.358)	0.111 (0, 0.405)	0.115 (0.017, 0.468)	0 (0, 0.307)	0.019 (0, 0.713)	0.183 (0.029, 9.55)
-+-+-	graduation	0	27	28	290	308	17
-+-+-	futility	0	161	138	1	3	140
-+-+-	max_n	0	52	30	38	42	43
-+-+-	n	12 (8, 18)	4 (0, 9)	4 (1, 9)	7 (3, 13)	7 (2, 13)	4 (2, 9)
-+-+-	n_unique	11 (7, 16)	3 (0, 8)	4 (1, 8)	6 (2, 12)	6 (2, 12)	4 (1, 8)
-+-+-	post_p	NA (NA, NA)	0.37 (0.19, 0.63)	0.37 (0.18, 0.63)	0.88 (0.58, 0.99)	0.87 (0.58, 0.98)	0.35 (0.18, 0.65)
-+-+-	rate	0.113 (0.071, 0.173)	0.126 (0.064, 0.386)	0.127 (0.066, 0.302)	0.036 (0.015, 0.075)	0.035 (0.015, 0.076)	0.131 (0.062, 0.272)
-+-++	graduation	0	31	32	294	308	18
-+-++	futility	0	172	148	9	10	159
-+-++	max_n	0	52	30	38	42	43
-+-++	n	5 (2, 8)	2 (0, 5)	2 (0, 5)	2 (0, 6)	2 (0, 6)	2 (0, 5)
-+-++	n_unique	4 (2, 8)	1 (0, 5)	2 (0, 5)	2 (0, 6)	2 (0, 5)	2 (0, 5)
-+-++	post_p	NA (NA, NA)	0.41 (0.25, 0.64)	0.42 (0.27, 0.6)	0.67 (0.43, 0.87)	0.65 (0.43, 0.86)	0.42 (0.26, 0.61)
-+-++	rate	0.12 (0.057, 0.251)	0.135 (0.048, 0.559)	0.128 (0.057, 0.455)	0.037 (0, 0.127)	0.038 (0, 0.122)	0.125 (0.044, 0.399)
-++–	graduation	0	11	4	290	296	6
-++–	futility	0	69	71	11	15	72
-++–	max_n	0	0	0	0	0	0
-++–	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	post_p	NA (NA, NA)	0.44 (0.43, 0.47)	0.48 (0.43, 0.57)	0.54 (0.48, 0.55)	0.64 (0.64, 0.64)	NA (NA, NA)
-++–	rate	0.16 (0, 0.602)	0.172 (0, 1.231)	0.103 (0, 0.484)	0.053 (0, 0.131)	0.052 (0, 0.164)	0.174 (0.079, 0.634)
-++-+	graduation	0	15	7	295	298	7
-++-+	futility	0	92	92	19	19	94
-++-+	max_n	0	0	0	0	0	0
-++-+	n	3 (0, 5)	1 (0, 4)	2 (0, 4)	1 (0, 4)	1 (0, 4)	1 (0, 3)
-++-+	n_unique	2 (0, 5)	1 (0, 3)	1 (0, 4)	1 (0, 4)	1 (0, 4)	1 (0, 3)
-++-+	post_p	NA (NA, NA)	0.44 (0.32, 0.62)	0.44 (0.31, 0.62)	0.6 (0.42, 0.8)	0.62 (0.45, 0.82)	0.45 (0.3, 0.62)
-++-+	rate	0.121 (0.045, 0.388)	0.129 (0.023, 0.525)	0.136 (0.029, 0.506)	0.044 (0, 0.201)	0.034 (0, 0.136)	0.131 (0.036, 0.577)
-+++-	graduation	0	13	6	292	297	7
-+++-	futility	0	81	83	11	15	79
-+++-	max_n	0	0	0	0	0	0
-+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	post_p	NA (NA, NA)	0.46 (0.46, 0.46)	0.47 (0.45, 0.49)	0.61 (0.61, 0.61)	0.56 (0.52, 0.57)	0.54 (0.51, 0.57)
-+++-	rate	0.147 (0, 1.081)	0.172 (0.056, 3)	0.099 (0, 0.426)	0 (0, 0.204)	0.023 (0, 0.258)	0.152 (0, 0.385)
-++++	graduation	0	17	9	297	299	8
-++++	futility	0	100	101	19	19	101
-++++	max_n	0	0	0	0	0	0
-++++	n	3 (1, 5)	1 (0, 3)	1 (0, 4)	2 (0, 4)	2 (0, 4)	2 (0, 3)
-++++	n_unique	2 (0, 5)	1 (0, 3)	1 (0, 4)	1 (0, 4)	1 (0, 3)	1 (0, 3)
-++++	post_p	NA (NA, NA)	0.45 (0.31, 0.62)	0.45 (0.29, 0.62)	0.59 (0.44, 0.83)	0.58 (0.41, 0.78)	0.45 (0.31, 0.64)
-++++	rate	0.121 (0.042, 0.329)	0.129 (0, 0.543)	0.136 (0, 0.507)	0.036 (0, 0.159)	0.04 (0, 0.169)	0.129 (0.028, 0.522)
+—-	graduation	0	6	1	14	15	3
+—-	futility	0	7	3	0	0	4
+—-	max_n	0	0	0	0	0	0
+—-	n	5 (2, 7)	3 (1, 5)	3 (1, 6)	2 (0, 5)	2 (0, 5)	2 (0, 5)
+—-	n_unique	4 (2, 7)	2 (0, 5)	3 (1, 5)	2 (0, 5)	2 (0, 4)	2 (0, 5)
+—-	post_p	NA (NA, NA)	0.48 (0.29, 0.73)	0.46 (0.27, 0.74)	0.48 (0.3, 0.71)	0.47 (0.31, 0.76)	0.45 (0.28, 0.72)
+—-	rate	0.111 (0.05, 0.257)	0.13 (0.053, 0.402)	0.126 (0.063, 0.401)	0.131 (0.04, 0.48)	0.128 (0.043, 0.443)	0.141 (0.031, 0.566)
+—+	graduation	0	11	6	23	27	5
+—+	futility	0	35	33	8	9	42
+—+	max_n	0	0	0	0	0	0
+—+	n	2 (0, 4)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)
+—+	n_unique	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 2)	1 (0, 3)
+—+	post_p	NA (NA, NA)	0.48 (0.35, 0.66)	0.47 (0.33, 0.66)	0.49 (0.34, 0.68)	0.48 (0.35, 0.67)	0.5 (0.34, 0.68)
+—+	rate	0.127 (0.032, 0.496)	0.131 (0, 0.464)	0.148 (0.039, 0.579)	0.118 (0, 0.697)	0.143 (0, 0.808)	0.132 (0, 0.463)
+–+-	graduation	0	8	3	20	23	5
+–+-	futility	0	23	21	1	1	18
+–+-	max_n	0	0	0	0	0	0
+–+-	n	7 (4, 12)	4 (1, 7)	5 (2, 8)	3 (1, 7)	3 (1, 7)	3 (1, 8)
+–+-	n_unique	6 (3, 11)	3 (1, 7)	4 (2, 8)	3 (1, 7)	3 (1, 6)	3 (1, 7)
+–+-	post_p	NA (NA, NA)	0.46 (0.23, 0.76)	0.47 (0.24, 0.8)	0.46 (0.24, 0.77)	0.45 (0.25, 0.8)	0.48 (0.27, 0.77)
+–+-	rate	0.114 (0.066, 0.2)	0.13 (0.061, 0.395)	0.122 (0.063, 0.326)	0.132 (0.052, 0.367)	0.142 (0.051, 0.443)	0.13 (0.06, 0.37)
+–++	graduation	0	13	8	29	35	7
+–++	futility	0	47	47	9	9	51
+–++	max_n	0	0	0	0	0	0
+–++	n	3 (1, 7)	2 (0, 5)	2 (0, 4)	2 (0, 4)	2 (0, 4)	2 (1, 5)
+–++	n_unique	3 (1, 6)	2 (0, 4)	2 (0, 4)	2 (0, 4)	2 (0, 4)	2 (0, 5)
+–++	post_p	NA (NA, NA)	0.49 (0.31, 0.73)	0.47 (0.29, 0.71)	0.48 (0.3, 0.72)	0.46 (0.31, 0.73)	0.49 (0.3, 0.74)
+–++	rate	0.122 (0.04, 0.276)	0.119 (0.032, 0.47)	0.136 (0.046, 0.528)	0.129 (0.04, 0.513)	0.142 (0.04, 0.617)	0.128 (0.048, 0.429)
+-+–	graduation	0	11	3	21	23	6
+-+–	futility	0	47	44	13	21	42
+-+–	max_n	0	0	0	0	0	0
+-+–	n	1 (0, 3)	1 (0, 2)	1 (0, 3)	1 (0, 2)	1 (0, 2)	1 (0, 2)
+-+–	n_unique	1 (0, 3)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)
+-+–	post_p	NA (NA, NA)	0.48 (0.39, 0.67)	0.49 (0.37, 0.63)	0.48 (0.38, 0.63)	0.48 (0.38, 0.65)	0.48 (0.37, 0.65)
+-+–	rate	0.122 (0, 0.539)	0.14 (0, 0.622)	0.13 (0, 0.762)	0.138 (0, 0.594)	0.14 (0, 0.541)	0.133 (0, 0.742)
+-+-+	graduation	0	16	6	29	35	7
+-+-+	futility	0	71	68	21	25	64
+-+-+	max_n	0	0	0	0	0	0
+-+-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	post_p	NA (NA, NA)	0.58 (0.55, 0.59)	0.5 (0.5, 0.5)	0.5 (0.5, 0.5)	0.44 (0.44, 0.44)	0.46 (0.44, 0.47)
+-+-+	rate	0.089 (0, 1.11)	0.088 (0, 0.476)	0.119 (0, 1.14)	0.09 (0, 0.904)	0.335 (0, 1.627)	0.152 (0, 0.362)
+-++-	graduation	0	13	5	26	30	7
+-++-	futility	0	59	58	14	21	49
+-++-	max_n	0	0	0	0	0	0
+-++-	n	21 (15, 28)	8 (3, 17)	10 (4, 21)	8 (3, 19)	8 (3, 18)	8 (3, 18)
+-++-	n_unique	19 (13, 26)	7 (3, 15)	9 (4, 19)	7 (3, 17)	7 (3, 16)	7 (2, 17)
+-++-	post_p	NA (NA, NA)	0.44 (0.17, 0.84)	0.48 (0.17, 0.85)	0.44 (0.18, 0.83)	0.47 (0.18, 0.83)	0.44 (0.19, 0.85)
+-++-	rate	0.115 (0.083, 0.155)	0.129 (0.075, 0.283)	0.122 (0.082, 0.228)	0.127 (0.078, 0.263)	0.12 (0.073, 0.261)	0.128 (0.074, 0.341)
+-+++	graduation	0	18	8	34	42	8
+-+++	futility	0	79	78	22	25	71
+-+++	max_n	0	0	0	0	0	0
+-+++	n	16 (11, 22)	6 (2, 14)	7 (3, 14)	7 (2, 15)	7 (2, 14)	8 (3, 16)
+-+++	n_unique	14 (9, 20)	5 (2, 13)	6 (2, 13)	6 (2, 13)	6 (2, 13)	7 (3, 14)
+-+++	post_p	NA (NA, NA)	0.47 (0.22, 0.81)	0.46 (0.18, 0.81)	0.46 (0.2, 0.82)	0.48 (0.21, 0.84)	0.46 (0.2, 0.82)
+-+++	rate	0.115 (0.08, 0.165)	0.126 (0.076, 0.3)	0.127 (0.076, 0.316)	0.126 (0.075, 0.301)	0.123 (0.073, 0.264)	0.128 (0.076, 0.281)
++—	graduation	0	6	2	289	296	3
++—	futility	0	33	34	0	0	38
++—	max_n	0	0	0	0	0	0
++—	n	8 (5, 13)	3 (1, 7)	3 (1, 7)	4 (2, 10)	5 (2, 10)	3 (1, 7)
++—	n_unique	7 (4, 12)	3 (1, 6)	3 (1, 6)	4 (1, 9)	4 (1, 9)	3 (1, 6)
++—	post_p	NA (NA, NA)	0.39 (0.2, 0.64)	0.4 (0.21, 0.65)	0.77 (0.46, 0.96)	0.78 (0.51, 0.96)	0.38 (0.22, 0.63)
++—	rate	0.115 (0.067, 0.194)	0.132 (0.05, 0.372)	0.12 (0.056, 0.321)	0.038 (0.012, 0.102)	0.037 (0.011, 0.089)	0.127 (0.054, 0.349)
++–+	graduation	0	10	7	294	298	5
++–+	futility	0	60	60	8	8	75
++–+	max_n	0	0	0	0	0	0
++–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	post_p	NA (NA, NA)	0.5 (0.44, 0.52)	0.53 (0.47, 0.57)	0.5 (0.5, 0.5)	NA (NA, NA)	0.46 (0.46, 0.47)
++–+	rate	0.068 (0, 0.675)	0.27 (0, 0.996)	0.111 (0, 0.614)	0 (0, 0.082)	0.066 (0, 0.343)	0.181 (0.01, 0.862)
++-+-	graduation	0	8	4	291	297	5
++-+-	futility	0	49	50	0	1	52
++-+-	max_n	0	0	0	0	0	0
++-+-	n	1 (0, 2)	0 (0, 2)	1 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)
++-+-	n_unique	1 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)
++-+-	post_p	NA (NA, NA)	0.46 (0.4, 0.59)	0.47 (0.38, 0.58)	0.57 (0.43, 0.65)	0.55 (0.44, 0.66)	0.47 (0.4, 0.6)
++-+-	rate	0.146 (0, 0.619)	0.148 (0, 1.051)	0.144 (0, 0.644)	0.032 (0, 0.192)	0.031 (0, 0.23)	0.146 (0, 0.73)
++-++	graduation	0	12	9	296	299	7
++-++	futility	0	72	73	8	8	84
++-++	max_n	0	0	0	0	0	0
++-++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	post_p	NA (NA, NA)	0.55 (0.55, 0.55)	0.5 (0.44, 0.56)	0.58 (0.58, 0.58)	0.57 (0.57, 0.57)	0.46 (0.46, 0.46)
++-++	rate	0.153 (0, 0.433)	0.077 (0, 0.61)	0.197 (0, 0.608)	0.029 (0, 0.123)	0.04 (0, 0.176)	0.15 (0, 2.599)
+++–	graduation	0	11	4	290	296	6
+++–	futility	0	69	71	11	15	72
+++–	max_n	0	0	0	0	0	0
+++–	n	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	n_unique	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	post_p	NA (NA, NA)	0.48 (0.43, 0.57)	0.5 (0.41, 0.57)	0.54 (0.47, 0.59)	0.53 (0.46, 0.59)	0.5 (0.41, 0.57)
+++–	rate	0.125 (0, 0.904)	0.116 (0, 1.111)	0.11 (0, 0.417)	0.038 (0, 0.165)	0.02 (0, 0.215)	0.147 (0, 0.684)
+++-+	graduation	0	15	7	295	298	7
+++-+	futility	0	92	92	19	19	94
+++-+	max_n	0	0	0	0	0	0
+++-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	post_p	NA (NA, NA)	0.53 (0.53, 0.53)	0.52 (0.52, 0.52)	0.48 (0.48, 0.48)	0.56 (0.5, 0.58)	NA (NA, NA)
+++-+	rate	0.133 (0, 0.634)	0.128 (0, 0.41)	0.06 (0, 0.199)	0.075 (0, 1.073)	0.055 (0, 0.185)	0.043 (0, 0.759)
++++-	graduation	0	13	6	292	297	7
++++-	futility	0	81	83	11	15	79
++++-	max_n	0	0	0	0	0	0
++++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	post_p	NA (NA, NA)	0.46 (0.46, 0.46)	0.52 (0.52, 0.52)	0.55 (0.49, 0.56)	0.54 (0.52, 0.58)	0.45 (0.43, 0.5)
++++-	rate	0.221 (0, 0.594)	0.147 (0, 4.556)	0.16 (0, 0.355)	0.036 (0, 0.133)	0.04 (0, 0.462)	0.214 (0, 1.166)
+++++	graduation	0	17	9	297	299	8
+++++	futility	0	100	101	19	19	101
+++++	max_n	0	0	0	0	0	0
+++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	post_p	NA (NA, NA)	0.44 (0.44, 0.44)	0.51 (0.5, 0.54)	NA (NA, NA)	NA (NA, NA)	0.52 (0.52, 0.52)
+++++	rate	0.122 (0, 1.294)	0.283 (0, 7.532)	0.105 (0, 1.081)	0 (0, 0.09)	0.057 (0, 0.512)	0.128 (0, 0.355)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count	6	1	14	15	3
all	time_stop	5 (3, 6)	4 (4, 4)	7 (6, 9)	8 (6, 13)	7 (7, 7)
all	n_trt	33 (26, 38)	25 (25, 25)	30 (27, 35)	30 (25, 50)	27 (27, 31)
all	n_control	46 (33, 63)	48 (48, 48)	68 (53, 86)	70 (55, 119)	68 (61, 78)
all	post_p	0.87 (0.86, 0.9)	0.92 (0.92, 0.92)	0.97 (0.89, 1)	0.99 (0.9, 1)	0.9 (0.87, 0.91)
all	order	1 (1, 1)	1 (1, 1)	1 (1, 1)	1 (1, 1)	1 (1, 1)
AR- & TP53-	count	20	24	39	50	13
AR- & TP53-	time_stop	9 (6, 14)	10 (7, 14)	14 (9, 25)	14 (10, 27)	12 (10, 14)
AR- & TP53-	n_trt	33 (26, 61)	29 (25, 43)	40 (26, 92)	35 (25, 88)	32 (25, 45)
AR- & TP53-	n_control	46 (32, 79)	52 (39, 80)	71 (53, 142)	79 (54, 165)	59 (51, 82)
AR- & TP53-	post_p	0.91 (0.88, 0.96)	0.9 (0.86, 0.94)	0.99 (0.94, 1)	0.99 (0.95, 1)	0.92 (0.88, 0.98)
AR- & TP53-	order	1 (1, 1.2)	1 (1, 1)	1 (1, 3)	1 (1, 2.1)	1 (1, 2)
HRD+	count		1	275	281
HRD+	time_stop		26 (26, 26)	23 (17, 33)	24 (17, 32)
HRD+	n_trt		25 (25, 25)	27 (25, 45)	28 (25, 42)
HRD+	n_control		41 (41, 41)	32 (22, 52)	36 (22, 52)
HRD+	post_p		0.93 (0.93, 0.93)	1 (0.98, 1)	1 (0.98, 1)
HRD+	order		5 (5, 5)	1 (1, 3)	2 (1, 3)
TP53+	count	5	2	7	8	3
TP53+	time_stop	17 (14, 21)	16 (14, 17)	19 (13, 23)	18 (15, 22)	15 (13, 23)
TP53+	n_trt	34 (29, 44)	27 (25, 29)	30 (28, 35)	33 (27, 42)	32 (26, 38)
TP53+	n_control	49 (35, 64)	42 (41, 43)	47 (35, 72)	51 (36, 72)	42 (37, 82)
TP53+	post_p	0.93 (0.87, 0.98)	0.94 (0.9, 0.97)	0.98 (0.94, 0.99)	0.98 (0.95, 0.99)	0.94 (0.93, 0.96)
TP53+	order	1 (1, 2)	1.5 (1.1, 1.9)	1 (1, 2)	2 (1, 2)	2 (1.2, 2)
TEfus+	count	2	2	6	9	2
TEfus+	time_stop	12 (10, 14)	16 (15, 16)	12 (10, 20)	18 (13, 19)	14 (12, 15)
TEfus+	n_trt	26 (26, 26)	36 (36, 36)	26 (25, 36)	27 (25, 37)	28 (26, 30)
TEfus+	n_control	41 (34, 48)	45 (40, 50)	32 (24, 60)	45 (31, 54)	33 (31, 35)
TEfus+	post_p	0.92 (0.87, 0.98)	0.89 (0.89, 0.9)	0.98 (0.95, 0.99)	0.98 (0.95, 1)	0.9 (0.87, 0.93)
TEfus+	order	1 (1, 1)	1 (1, 1)	1 (1, 2.5)	1 (1, 3)	1.5 (1.1, 1.9)
PI3K+	count	5	5	9	12	2
PI3K+	time_stop	22 (14, 24)	14 (12, 18)	15 (14, 19)	16 (13, 22)	15 (13, 17)
PI3K+	n_trt	38 (31, 49)	26 (25, 27)	28 (26, 33)	26 (25, 37)	36 (32, 40)
PI3K+	n_control	69 (50, 81)	41 (35, 47)	45 (30, 64)	52 (37, 72)	46 (40, 51)
PI3K+	post_p	0.96 (0.9, 0.99)	0.96 (0.89, 0.99)	0.96 (0.95, 0.99)	0.99 (0.91, 0.99)	0.92 (0.9, 0.94)
PI3K+	order	1 (1, 3.2)	2 (1, 2)	1 (1, 2.2)	1 (1, 2.9)	1 (1, 1)

Futility:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count	7	3			4
all	time_stop	6 (4, 7)	5 (3, 5)			10 (10, 11)
all	n_trt	32 (27, 42)	25 (25, 27)			50 (37, 54)
all	n_control	54 (31, 62)	49 (29, 51)			92 (77, 106)
all	post_p	0.04 (0.01, 0.17)	0.07 (0.04, 0.14)			0.01 (0, 0.11)
all	order	1 (1, 2)	1 (1, 1)			1 (1, 1.7)
AR- & TP53-	count	131	103	1	2	101
AR- & TP53-	time_stop	13 (6, 29)	18 (11, 33)	11 (11, 11)	17 (15, 19)	20 (11, 33)
AR- & TP53-	n_trt	40 (26, 73)	35 (26, 78)	26 (26, 26)	37 (27, 47)	39 (26, 65)
AR- & TP53-	n_control	68 (36, 166)	98 (55, 191)	58 (58, 58)	94 (80, 108)	107 (49, 193)
AR- & TP53-	post_p	0.13 (0.03, 0.23)	0.16 (0.03, 0.27)	0.27 (0.27, 0.27)	0.19 (0.15, 0.23)	0.1 (0.04, 0.24)
AR- & TP53-	order	1 (1, 2)	1 (1, 3)	1 (1, 1)	3 (1.4, 4.6)	2 (1, 3)
HRD+	count	26	31			34
HRD+	time_stop	32 (28, 35)	34 (26, 36)			32 (25, 36)
HRD+	n_trt	27 (25, 40)	27 (25, 35)			26 (25, 32)
HRD+	n_control	52 (40, 69)	51 (39, 65)			52 (36, 66)
HRD+	post_p	0.15 (0.02, 0.25)	0.14 (0.07, 0.28)			0.11 (0.03, 0.24)
HRD+	order	2 (1, 4)	2 (1, 3)			2 (1, 3)
TP53+	count	40	41	13	21	38
TP53+	time_stop	20 (15, 33)	21 (14, 30)	21 (17, 33)	24 (19, 32)	24 (13, 32)
TP53+	n_trt	33 (26, 45)	31 (25, 52)	27 (25, 36)	31 (25, 39)	31 (25, 47)
TP53+	n_control	62 (37, 118)	67 (40, 98)	55 (47, 107)	76 (58, 102)	70 (35, 110)
TP53+	post_p	0.09 (0.02, 0.18)	0.07 (0.02, 0.22)	0.11 (0.01, 0.19)	0.11 (0.01, 0.21)	0.08 (0.01, 0.22)
TP53+	order	1.5 (1, 3)	2 (1, 3)	2 (1, 3)	2 (1, 3)	2 (1, 3)
TEfus+	count	16	18	1	1	15
TEfus+	time_stop	22 (19, 32)	17 (14, 26)	15 (15, 15)	25 (25, 25)	19 (12, 28)
TEfus+	n_trt	28 (26, 36)	29 (25, 42)	25 (25, 25)	39 (39, 39)	30 (25, 41)
TEfus+	n_control	64 (50, 103)	52 (35, 82)	30 (30, 30)	82 (82, 82)	52 (32, 87)
TEfus+	post_p	0.06 (0.02, 0.17)	0.07 (0.01, 0.22)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.06 (0, 0.16)
TEfus+	order	2 (1, 5)	3 (1, 3.3)	1 (1, 1)	4 (4, 4)	2 (1, 3)
PI3K+	count	28	30	8	9	40
PI3K+	time_stop	24 (16, 32)	20 (17, 30)	18 (15, 26)	26 (22, 32)	20 (9, 30)
PI3K+	n_trt	32 (26, 41)	28 (25, 43)	28 (26, 35)	37 (26, 48)	30 (25, 53)
PI3K+	n_control	68 (41, 103)	63 (47, 97)	55 (45, 79)	88 (67, 120)	56 (24, 96)
PI3K+	post_p	0.07 (0, 0.24)	0.06 (0.01, 0.22)	0.1 (0.01, 0.27)	0.09 (0.04, 0.29)	0.08 (0.02, 0.19)
PI3K+	order	2 (1, 3)	2 (1, 3.1)	2 (1, 3.3)	3 (1, 4.2)	2 (1, 3)

By subgroup combinations

Graduation:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC1	count	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6
all	TC1	time	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)
all	TC1	n	18 (14, 21)	2 (0, 4)	0 (0, 1)	0 (0, 2)	4 (2, 6)	1 (0, 3)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (0, 2)	0 (0, 2)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.63 (0.55, 0.78)	0.56 (0.55, 0.62)	0.5 (0.5, 0.5)	0.52 (0.52, 0.56)	0.56 (0.51, 0.61)	0.55 (0.53, 0.57)	NA (NA, NA)	0.54 (0.53, 0.57)	0.5 (0.5, 0.5)	NA (NA, NA)	0.51 (0.5, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.56 (0.54, 0.59)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.54 (0.52, 0.54)	0.59 (0.54, 0.6)	0.51 (0.5, 0.51)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)	0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.05 (0.035, 0.076)	0 (0, 0)	0 (0, 0)	0 (0, 0.26)	0 (0, 0.108)	0 (0, 1.867)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0.103)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
all	TC2	time	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)
all	TC2	n	9 (9, 9)	0 (0, 0)	1 (1, 1)	0 (0, 0)	3 (3, 3)	2 (2, 2)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)	1 (1, 1)	0 (0, 0)	1 (1, 1)	0 (0, 0)	3 (3, 3)	2 (2, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.86 (0.86, 0.86)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.62 (0.62, 0.62)	0.53 (0.53, 0.53)	NA (NA, NA)	0.55 (0.55, 0.55)	NA (NA, NA)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.55 (0.55, 0.55)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)	0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	5.034 (5.034, 5.034)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14	14
all	TC3	time	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)	7 (6, 9)
all	TC3	n	6 (4, 14)	1 (0, 2)	0 (0, 2)	1 (0, 1)	2 (0, 4)	2 (1, 3)	0 (0, 1)	1 (0, 3)	4 (2, 9)	0 (0, 0)	2 (1, 5)	1 (0, 3)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 2)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	2 (0, 3)	1 (0, 2)	2 (1, 4)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.64 (0.54, 0.76)	0.56 (0.54, 0.66)	0.67 (0.67, 0.67)	0.52 (0.51, 0.57)	0.57 (0.51, 0.65)	0.58 (0.52, 0.66)	0.51 (0.51, 0.51)	0.53 (0.5, 0.55)	0.58 (0.54, 0.66)	NA (NA, NA)	0.54 (0.51, 0.6)	0.55 (0.51, 0.63)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)	0.52 (0.52, 0.55)	0.52 (0.5, 0.53)	NA (NA, NA)	0.52 (0.51, 0.54)	0.54 (0.51, 0.58)	NA (NA, NA)	NA (NA, NA)	0.55 (0.5, 0.6)	0.55 (0.54, 0.63)	0.55 (0.53, 0.59)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC3	rate	0.019 (0, 0.12)	0 (0, 0.024)	0 (0, 0.073)	0 (0, 0)	0 (0, 0.167)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.092)	NA (NA, NA)	0 (0, 0.13)	0 (0, 0.019)	3.523 (3.523, 3.523)	0 (0, 2.039)	NA (NA, NA)	0 (0, 0.151)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.602)	NA (NA, NA)	NA (NA, NA)	0 (0, 0.124)	0 (0, 0)	0 (0, 0.07)	NA (NA, NA)	0.11 (0.022, 0.198)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)
all	TC4	count	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15
all	TC4	time	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)	8 (6, 13)
all	TC4	n	9 (4, 15)	1 (0, 5)	0 (0, 0)	1 (0, 2)	2 (0, 6)	2 (0, 4)	0 (0, 1)	1 (0, 4)	5 (2, 8)	0 (0, 0)	2 (0, 5)	1 (0, 2)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 2)	0 (0, 1)	0 (0, 0)	0 (0, 2)	0 (0, 1)	0 (0, 1)	0 (0, 0)	2 (1, 4)	1 (0, 3)	1 (0, 4)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.6 (0.55, 0.79)	0.63 (0.54, 0.66)	NA (NA, NA)	0.56 (0.5, 0.7)	0.56 (0.52, 0.64)	0.57 (0.53, 0.68)	0.54 (0.51, 0.59)	0.55 (0.5, 0.8)	0.57 (0.52, 0.78)	NA (NA, NA)	0.59 (0.54, 0.82)	0.54 (0.52, 0.62)	NA (NA, NA)	0.57 (0.55, 0.6)	NA (NA, NA)	0.57 (0.55, 0.62)	0.56 (0.56, 0.56)	NA (NA, NA)	0.54 (0.52, 0.56)	0.54 (0.53, 0.55)	0.54 (0.54, 0.54)	NA (NA, NA)	0.55 (0.53, 0.65)	0.62 (0.53, 0.72)	0.53 (0.5, 0.56)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC4	rate	0.079 (0, 0.11)	0 (0, 0)	0 (0, 0)	0 (0, 0.317)	0 (0, 0.085)	0 (0, 0.103)	0 (0, 0)	0 (0, 0.123)	0 (0, 0.031)	NA (NA, NA)	0 (0, 0.017)	0 (0, 0)	NA (NA, NA)	0 (0, 0.012)	NA (NA, NA)	0 (0, 0.178)	0 (0, 0)	NA (NA, NA)	0 (0, 0.037)	0 (0, 0)	0 (0, 0.081)	NA (NA, NA)	0 (0, 0.095)	0 (0, 0.068)	0 (0, 0.103)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)
all	TC5	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
all	TC5	time	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)
all	TC5	n	5 (5, 6)	7 (5, 8)	0 (0, 1)	1 (0, 2)	3 (3, 5)	4 (2, 4)	0 (0, 0)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 2)	0 (0, 1)	1 (0, 2)	1 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 1)	4 (3, 5)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)
all	TC5	post_p	0.65 (0.56, 0.68)	0.67 (0.65, 0.73)	0.51 (0.51, 0.51)	0.53 (0.52, 0.54)	0.54 (0.53, 0.71)	0.54 (0.52, 0.59)	NA (NA, NA)	NA (NA, NA)	0.53 (0.51, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.58 (0.58, 0.58)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	0.51 (0.51, 0.51)	0.6 (0.54, 0.61)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	rate	0 (0, 0.082)	0.048 (0.032, 0.099)	0 (0, 0)	0 (0, 0)	0 (0, 0.08)	0.073 (0.071, 0.116)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0.093 (0.019, 0.152)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)
AR- & TP53-	TC1	count	20	20	20	20					20	20	20	20
AR- & TP53-	TC1	time	9 (6, 14)	9 (6, 14)	9 (6, 14)	9 (6, 14)					9 (6, 14)	9 (6, 14)	9 (6, 14)	9 (6, 14)
AR- & TP53-	TC1	n	23 (18, 39)	4 (2, 9)	1 (0, 2)	2 (0, 4)					1 (0, 4)	0 (0, 0)	1 (0, 2)	0 (0, 1)
AR- & TP53-	TC1	post_p	0.82 (0.74, 0.93)	0.71 (0.53, 0.78)	0.53 (0.51, 0.55)	0.6 (0.55, 0.74)					0.56 (0.51, 0.65)	NA (NA, NA)	0.53 (0.53, 0.71)	0.53 (0.53, 0.54)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.073 (0.055, 0.097)	0.032 (0, 0.083)	0 (0, 0.22)	0 (0, 0.068)					0 (0, 0.041)	NA (NA, NA)	0 (0, 0)	0 (0, 0.428)
AR- & TP53-	TC2	count	24	24	24	24					24	24	24	24
AR- & TP53-	TC2	time	10 (7, 14)	10 (7, 14)	10 (7, 14)	10 (7, 14)					10 (7, 14)	10 (7, 14)	10 (7, 14)	10 (7, 14)
AR- & TP53-	TC2	n	21 (16, 31)	3 (1, 4)	0 (0, 3)	2 (0, 4)					2 (1, 5)	0 (0, 0)	0 (0, 2)	0 (0, 1)
AR- & TP53-	TC2	post_p	0.81 (0.73, 0.94)	0.6 (0.52, 0.69)	0.58 (0.54, 0.63)	0.55 (0.52, 0.66)					0.55 (0.51, 0.61)	NA (NA, NA)	0.54 (0.51, 0.58)	0.53 (0.5, 0.56)
AR- & TP53-	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC2	rate	0.067 (0.046, 0.095)	0 (0, 0.098)	0 (0, 0.239)	0 (0, 0.065)					0 (0, 0.064)	NA (NA, NA)	0 (0, 0.335)	0 (0, 0.148)
AR- & TP53-	TC3	count	39	39	39	39					39	39	39	39
AR- & TP53-	TC3	time	14 (9, 25)	14 (9, 25)	14 (9, 25)	14 (9, 25)					14 (9, 25)	14 (9, 25)	14 (9, 25)	14 (9, 25)
AR- & TP53-	TC3	n	19 (12, 55)	4 (0, 11)	0 (0, 2)	3 (0, 5)					8 (4, 15)	0 (0, 0)	3 (2, 8)	1 (0, 3)
AR- & TP53-	TC3	post_p	0.8 (0.72, 0.93)	0.62 (0.52, 0.77)	0.56 (0.5, 0.71)	0.58 (0.51, 0.75)					0.8 (0.6, 0.96)	NA (NA, NA)	0.62 (0.53, 0.85)	0.59 (0.53, 0.67)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.079 (0.043, 0.094)	0.072 (0, 0.116)	0 (0, 0.263)	0.054 (0, 0.131)					0.029 (0, 0.056)	NA (NA, NA)	0.017 (0, 0.065)	0 (0, 0.103)
AR- & TP53-	TC4	count	50	50	50	50					50	50	50	50
AR- & TP53-	TC4	time	14 (10, 27)	14 (10, 27)	14 (10, 27)	14 (10, 27)					14 (10, 27)	14 (10, 27)	14 (10, 27)	14 (10, 27)
AR- & TP53-	TC4	n	18 (10, 44)	4 (1, 13)	0 (0, 2)	2 (0, 5)					8 (4, 17)	0 (0, 0)	4 (2, 7)	1 (0, 4)
AR- & TP53-	TC4	post_p	0.79 (0.7, 0.92)	0.59 (0.52, 0.79)	0.56 (0.51, 0.66)	0.62 (0.53, 0.83)					0.75 (0.58, 0.96)	NA (NA, NA)	0.63 (0.52, 0.89)	0.57 (0.52, 0.77)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.079 (0.036, 0.103)	0.067 (0, 0.128)	0 (0, 0.126)	0.057 (0, 0.106)					0.028 (0, 0.053)	NA (NA, NA)	0.016 (0, 0.056)	0 (0, 0.096)
AR- & TP53-	TC5	count	13	13	13	13					13	13	13	13
AR- & TP53-	TC5	time	12 (10, 14)	12 (10, 14)	12 (10, 14)	12 (10, 14)					12 (10, 14)	12 (10, 14)	12 (10, 14)	12 (10, 14)
AR- & TP53-	TC5	n	18 (12, 25)	8 (4, 11)	0 (0, 2)	3 (0, 5)					2 (0, 4)	0 (0, 0)	0 (0, 2)	0 (0, 1)
AR- & TP53-	TC5	post_p	0.8 (0.72, 0.86)	0.76 (0.64, 0.84)	0.55 (0.53, 0.58)	0.62 (0.56, 0.72)					0.54 (0.52, 0.72)	NA (NA, NA)	0.55 (0.52, 0.59)	0.55 (0.54, 0.56)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.068 (0.031, 0.093)	0.043 (0.031, 0.091)	0.181 (0, 0.689)	0.066 (0.029, 0.114)					0 (0, 0.095)	NA (NA, NA)	0 (0, 0)	0 (0, 0.337)
HRD+	TC2	count									1	1	1	1	1	1	1	1									1	1	1	1	1	1	1	1
HRD+	TC2	time									26 (26, 26)	26 (26, 26)	26 (26, 26)	26 (26, 26)	26 (26, 26)	26 (26, 26)	26 (26, 26)	26 (26, 26)									26 (26, 26)	26 (26, 26)	26 (26, 26)	26 (26, 26)	26 (26, 26)	26 (26, 26)	26 (26, 26)	26 (26, 26)
HRD+	TC2	n									12 (12, 12)	0 (0, 0)	5 (5, 5)	2 (2, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									5 (5, 5)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.82 (0.82, 0.82)	NA (NA, NA)	0.5 (0.5, 0.5)	0.56 (0.56, 0.56)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)									0.63 (0.63, 0.63)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.044 (0.044, 0.044)	NA (NA, NA)	0.111 (0.111, 0.111)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)									0.043 (0.043, 0.043)	0.08 (0.08, 0.08)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	count									275	275	275	275	275	275	275	275									275	275	275	275	275	275	275	275
HRD+	TC3	time									23 (17, 33)	23 (17, 33)	23 (17, 33)	23 (17, 33)	23 (17, 33)	23 (17, 33)	23 (17, 33)	23 (17, 33)									23 (17, 33)	23 (17, 33)	23 (17, 33)	23 (17, 33)	23 (17, 33)	23 (17, 33)	23 (17, 33)	23 (17, 33)
HRD+	TC3	n									13 (8, 21)	0 (0, 0)	6 (3, 11)	2 (0, 5)	0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 4)									4 (1, 9)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.92 (0.74, 1)	0.57 (0.57, 0.57)	0.76 (0.55, 0.93)	0.6 (0.52, 0.78)	0.53 (0.53, 0.53)	0.56 (0.52, 0.69)	0.58 (0.58, 0.58)	0.58 (0.51, 0.71)									0.68 (0.53, 0.9)	NA (NA, NA)	0.56 (0.51, 0.67)	0.6 (0.6, 0.6)	0.55 (0.51, 0.59)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.032 (0.015, 0.054)	0 (0, 0.343)	0.032 (0, 0.068)	0.021 (0, 0.088)	0 (0, 0.093)	0 (0, 0.114)	0 (0, 0.155)	0 (0, 0.086)									0.028 (0, 0.078)	0 (0, 0.121)	0 (0, 0.116)	0.061 (0, 0.123)	0 (0, 0.15)	0.082 (0, 1.001)	0 (0, 0.736)	0 (0, 0.072)
HRD+	TC4	count									281	281	281	281	281	281	281	281									281	281	281	281	281	281	281	281
HRD+	TC4	time									24 (17, 32)	24 (17, 32)	24 (17, 32)	24 (17, 32)	24 (17, 32)	24 (17, 32)	24 (17, 32)	24 (17, 32)									24 (17, 32)	24 (17, 32)	24 (17, 32)	24 (17, 32)	24 (17, 32)	24 (17, 32)	24 (17, 32)	24 (17, 32)
HRD+	TC4	n									13 (9, 21)	0 (0, 0)	6 (3, 11)	2 (0, 5)	0 (0, 0)	1 (0, 4)	0 (0, 0)	1 (0, 3)									4 (2, 8)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.92 (0.74, 0.99)	NA (NA, NA)	0.75 (0.56, 0.95)	0.6 (0.52, 0.78)	0.58 (0.58, 0.58)	0.58 (0.51, 0.73)	0.55 (0.54, 0.55)	0.56 (0.51, 0.7)									0.7 (0.54, 0.89)	NA (NA, NA)	0.56 (0.51, 0.66)	0.58 (0.58, 0.58)	0.54 (0.51, 0.57)	0.53 (0.52, 0.55)	0.55 (0.51, 0.58)	NA (NA, NA)
HRD+	TC4	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.033 (0.014, 0.054)	0.025 (0, 0.849)	0.031 (0, 0.068)	0.025 (0, 0.082)	0 (0, 0.232)	0.015 (0, 0.087)	0.045 (0, 0.223)	0 (0, 0.091)									0.029 (0, 0.072)	0 (0, 0.066)	0 (0, 0.159)	0 (0, 0.059)	0 (0, 0.206)	0 (0, 0.39)	0.073 (0, 1.178)	0 (0, 0.21)
TP53+	TC1	count					5	5	5	5					5	5	5	5					5	5	5	5					5	5	5	5
TP53+	TC1	time					17 (14, 21)	17 (14, 21)	17 (14, 21)	17 (14, 21)					17 (14, 21)	17 (14, 21)	17 (14, 21)	17 (14, 21)					17 (14, 21)	17 (14, 21)	17 (14, 21)	17 (14, 21)					17 (14, 21)	17 (14, 21)	17 (14, 21)	17 (14, 21)
TP53+	TC1	n					8 (6, 12)	7 (2, 14)	4 (1, 5)	4 (3, 13)					0 (0, 0)	1 (0, 3)	0 (0, 0)	0 (0, 2)					0 (0, 1)	0 (0, 0)	4 (3, 7)	3 (0, 4)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.77 (0.72, 0.86)	0.72 (0.56, 0.75)	0.55 (0.53, 0.56)	0.74 (0.7, 0.87)					NA (NA, NA)	0.55 (0.51, 0.65)	NA (NA, NA)	0.61 (0.61, 0.61)					0.51 (0.51, 0.51)	NA (NA, NA)	0.7 (0.6, 0.78)	0.63 (0.54, 0.7)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.07 (0.057, 0.083)	0.071 (0.023, 0.096)	0.12 (0.032, 0.184)	0.08 (0.031, 0.095)					NA (NA, NA)	0 (0, 0.022)	NA (NA, NA)	0.077 (0.015, 0.138)					0 (0, 0)	NA (NA, NA)	0.102 (0.043, 0.165)	0.061 (0.037, 0.113)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	count					2	2	2	2					2	2	2	2					2	2	2	2					2	2	2	2
TP53+	TC2	time					16 (14, 17)	16 (14, 17)	16 (14, 17)	16 (14, 17)					16 (14, 17)	16 (14, 17)	16 (14, 17)	16 (14, 17)					16 (14, 17)	16 (14, 17)	16 (14, 17)	16 (14, 17)					16 (14, 17)	16 (14, 17)	16 (14, 17)	16 (14, 17)
TP53+	TC2	n					4 (4, 4)	4 (4, 4)	4 (3, 4)	3 (1, 5)					0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 0)					0 (0, 1)	0 (0, 0)	7 (5, 9)	4 (2, 5)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)
TP53+	TC2	post_p					0.72 (0.63, 0.81)	0.77 (0.63, 0.91)	0.58 (0.58, 0.59)	0.56 (0.56, 0.57)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	0.69 (0.68, 0.71)	0.55 (0.54, 0.56)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.047 (0.034, 0.059)	0.031 (0.026, 0.035)	0.081 (0.053, 0.108)	0.059 (0.012, 0.107)					NA (NA, NA)	0.054 (0.054, 0.054)	NA (NA, NA)	NA (NA, NA)					0.191 (0.191, 0.191)	NA (NA, NA)	0.091 (0.069, 0.113)	0.087 (0.059, 0.115)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)
TP53+	TC3	count					7	7	7	7					7	7	7	7					7	7	7	7					7	7	7	7
TP53+	TC3	time					19 (13, 23)	19 (13, 23)	19 (13, 23)	19 (13, 23)					19 (13, 23)	19 (13, 23)	19 (13, 23)	19 (13, 23)					19 (13, 23)	19 (13, 23)	19 (13, 23)	19 (13, 23)					19 (13, 23)	19 (13, 23)	19 (13, 23)	19 (13, 23)
TP53+	TC3	n					7 (4, 12)	5 (2, 9)	1 (0, 3)	4 (2, 9)					0 (0, 0)	1 (1, 2)	0 (0, 0)	1 (1, 2)					0 (0, 0)	0 (0, 0)	4 (3, 7)	5 (2, 5)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.8 (0.51, 0.87)	0.71 (0.53, 0.78)	0.57 (0.51, 0.6)	0.64 (0.56, 0.88)					NA (NA, NA)	0.52 (0.51, 0.52)	NA (NA, NA)	0.56 (0.51, 0.61)					NA (NA, NA)	NA (NA, NA)	0.69 (0.54, 0.8)	0.54 (0.52, 0.81)					0.59 (0.59, 0.59)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.059 (0.044, 0.111)	0.1 (0.032, 0.122)	0 (0, 0.053)	0.034 (0, 0.141)					NA (NA, NA)	0 (0, 0.134)	NA (NA, NA)	0.015 (0, 0.273)					NA (NA, NA)	NA (NA, NA)	0.066 (0.028, 0.13)	0.057 (0.018, 0.129)					0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)
TP53+	TC4	count					8	8	8	8					8	8	8	8					8	8	8	8					8	8	8	8
TP53+	TC4	time					18 (15, 22)	18 (15, 22)	18 (15, 22)	18 (15, 22)					18 (15, 22)	18 (15, 22)	18 (15, 22)	18 (15, 22)					18 (15, 22)	18 (15, 22)	18 (15, 22)	18 (15, 22)					18 (15, 22)	18 (15, 22)	18 (15, 22)	18 (15, 22)
TP53+	TC4	n					8 (5, 12)	7 (3, 12)	2 (0, 2)	4 (2, 6)					0 (0, 0)	1 (0, 2)	0 (0, 0)	2 (0, 3)					0 (0, 0)	0 (0, 0)	5 (4, 8)	4 (2, 9)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.78 (0.69, 0.93)	0.72 (0.63, 0.81)	0.55 (0.51, 0.59)	0.57 (0.53, 0.76)					NA (NA, NA)	0.55 (0.53, 0.56)	NA (NA, NA)	0.56 (0.54, 0.58)					NA (NA, NA)	NA (NA, NA)	0.73 (0.58, 0.8)	0.68 (0.52, 0.82)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.059 (0.049, 0.075)	0.061 (0.034, 0.086)	0.047 (0, 0.173)	0.055 (0, 0.098)					NA (NA, NA)	0 (0, 0.046)	NA (NA, NA)	0 (0, 0)					0 (0, 0)	NA (NA, NA)	0.061 (0.023, 0.105)	0.082 (0.013, 0.142)					0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)
TP53+	TC5	count					3	3	3	3					3	3	3	3					3	3	3	3					3	3	3	3
TP53+	TC5	time					15 (13, 23)	15 (13, 23)	15 (13, 23)	15 (13, 23)					15 (13, 23)	15 (13, 23)	15 (13, 23)	15 (13, 23)					15 (13, 23)	15 (13, 23)	15 (13, 23)	15 (13, 23)					15 (13, 23)	15 (13, 23)	15 (13, 23)	15 (13, 23)
TP53+	TC5	n					5 (3, 10)	7 (2, 10)	2 (1, 3)	5 (4, 8)					0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)					0 (0, 2)	0 (0, 0)	2 (1, 11)	4 (2, 9)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	post_p					0.75 (0.66, 0.91)	0.81 (0.6, 0.85)	0.53 (0.51, 0.56)	0.71 (0.57, 0.73)					NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	0.52 (0.52, 0.52)					NA (NA, NA)	NA (NA, NA)	0.56 (0.55, 0.71)	0.62 (0.59, 0.71)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	r_prob					0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	rate					0.033 (0.007, 0.058)	0.049 (0.01, 0.057)	0.12 (0.024, 0.138)	0.041 (0.008, 0.108)					NA (NA, NA)	0.077 (0.077, 0.077)	NA (NA, NA)	0 (0, 0)					0.204 (0.204, 0.204)	NA (NA, NA)	0 (0, 0.044)	0.084 (0.017, 0.124)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	count			2	2			2	2			2	2			2	2			2	2			2	2			2	2			2	2
TEfus+	TC1	time			12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)
TEfus+	TC1	n			2 (1, 3)	4 (4, 4)			1 (0, 2)	3 (1, 5)			1 (0, 2)	0 (0, 0)			0 (0, 0)	0 (0, 1)			2 (1, 2)	2 (0, 3)			7 (5, 9)	4 (4, 5)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.53 (0.53, 0.54)	0.59 (0.59, 0.59)			0.56 (0.56, 0.56)	0.63 (0.55, 0.71)			0.56 (0.56, 0.56)	NA (NA, NA)			NA (NA, NA)	0.52 (0.52, 0.52)			0.52 (0.52, 0.52)	0.62 (0.62, 0.62)			0.74 (0.57, 0.92)	0.75 (0.75, 0.75)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.37 (0.37, 0.37)	0.22 (0.22, 0.22)			0.18 (0.18, 0.18)	0.09 (0.09, 0.09)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.18 (0.18, 0.18)	0.14 (0.14, 0.14)			0.12 (0.12, 0.12)	0.07 (0.07, 0.07)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.138 (0.084, 0.191)	0.069 (0.046, 0.092)			0 (0, 0)	0.022 (0.004, 0.039)			0 (0, 0)	NA (NA, NA)			NA (NA, NA)	0 (0, 0)			0.032 (0.006, 0.058)	0 (0, 0)			0.077 (0.033, 0.12)	0.054 (0.011, 0.097)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	count			2	2			2	2			2	2			2	2			2	2			2	2			2	2			2	2
TEfus+	TC2	time			16 (15, 16)	16 (15, 16)			16 (15, 16)	16 (15, 16)			16 (15, 16)	16 (15, 16)			16 (15, 16)	16 (15, 16)			16 (15, 16)	16 (15, 16)			16 (15, 16)	16 (15, 16)			16 (15, 16)	16 (15, 16)			16 (15, 16)	16 (15, 16)
TEfus+	TC2	n			0 (0, 1)	2 (1, 3)			4 (4, 5)	4 (3, 4)			2 (0, 3)	3 (2, 4)			0 (0, 0)	2 (1, 2)			2 (1, 3)	1 (1, 1)			10 (9, 10)	6 (5, 7)			1 (1, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			NA (NA, NA)	0.68 (0.57, 0.79)			0.53 (0.51, 0.55)	0.51 (0.51, 0.51)			0.57 (0.57, 0.57)	0.58 (0.58, 0.58)			NA (NA, NA)	NA (NA, NA)			0.57 (0.56, 0.57)	0.55 (0.55, 0.55)			0.76 (0.75, 0.76)	0.66 (0.6, 0.72)			0.5 (0.5, 0.5)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.25 (0.25, 0.25)	0.03 (0.03, 0.03)			0.41 (0.41, 0.41)	0.16 (0.16, 0.16)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.41 (0.41, 0.41)	0.29 (0.29, 0.29)			0.37 (0.37, 0.37)	0.21 (0.21, 0.21)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.283 (0.283, 0.283)	0.024 (0.005, 0.043)			0.117 (0.107, 0.127)	0.135 (0.131, 0.14)			0 (0, 0)	0.115 (0.023, 0.207)			NA (NA, NA)	0.104 (0.021, 0.187)			0.037 (0.007, 0.067)	0 (0, 0)			0.08 (0.049, 0.111)	0.089 (0.084, 0.095)			0.113 (0.023, 0.203)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	count			6	6			6	6			6	6			6	6			6	6			6	6			6	6			6	6
TEfus+	TC3	time			12 (10, 20)	12 (10, 20)			12 (10, 20)	12 (10, 20)			12 (10, 20)	12 (10, 20)			12 (10, 20)	12 (10, 20)			12 (10, 20)	12 (10, 20)			12 (10, 20)	12 (10, 20)			12 (10, 20)	12 (10, 20)			12 (10, 20)	12 (10, 20)
TEfus+	TC3	n			1 (0, 2)	4 (1, 4)			2 (0, 2)	2 (1, 4)			4 (2, 8)	2 (1, 2)			0 (0, 0)	1 (0, 2)			1 (0, 4)	1 (0, 2)			4 (2, 4)	6 (4, 9)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.54 (0.54, 0.54)	0.63 (0.57, 0.68)			0.55 (0.51, 0.67)	0.6 (0.54, 0.65)			0.65 (0.59, 0.79)	0.55 (0.54, 0.56)			NA (NA, NA)	0.57 (0.53, 0.6)			0.57 (0.52, 0.71)	0.52 (0.52, 0.53)			0.6 (0.53, 0.66)	0.64 (0.52, 0.81)			0.58 (0.58, 0.58)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.037 (0, 0.521)	0.076 (0.025, 0.085)			0 (0, 0.056)	0 (0, 0.028)			0 (0, 0.037)	0 (0, 0.082)			NA (NA, NA)	0.015 (0, 0.102)			0.048 (0, 0.209)	0 (0, 4.559)			0.058 (0.022, 0.113)	0.084 (0.021, 0.14)			0 (0, 0)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	count			9	9			9	9			9	9			9	9			9	9			9	9			9	9			9	9
TEfus+	TC4	time			18 (13, 19)	18 (13, 19)			18 (13, 19)	18 (13, 19)			18 (13, 19)	18 (13, 19)			18 (13, 19)	18 (13, 19)			18 (13, 19)	18 (13, 19)			18 (13, 19)	18 (13, 19)			18 (13, 19)	18 (13, 19)			18 (13, 19)	18 (13, 19)
TEfus+	TC4	n			1 (0, 2)	3 (2, 6)			1 (1, 4)	3 (1, 9)			3 (2, 4)	2 (1, 3)			0 (0, 0)	2 (0, 4)			2 (1, 2)	1 (0, 1)			5 (3, 10)	5 (3, 8)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.64 (0.56, 0.74)	0.61 (0.52, 0.88)			0.58 (0.54, 0.66)	0.62 (0.53, 0.88)			0.64 (0.58, 0.85)	0.54 (0.52, 0.62)			NA (NA, NA)	0.59 (0.52, 0.63)			0.62 (0.57, 0.68)	0.56 (0.56, 0.56)			0.6 (0.53, 0.94)	0.56 (0.51, 0.75)			0.54 (0.53, 0.55)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0 (0, 0)	0.062 (0, 0.16)			0 (0, 0.049)	0.035 (0, 0.068)			0.012 (0, 0.043)	0.016 (0, 0.069)			NA (NA, NA)	0.021 (0, 0.052)			0 (0, 0.099)	0.275 (0, 0.572)			0.067 (0, 0.104)	0.059 (0.029, 0.116)			0.114 (0, 0.492)	0.09 (0.09, 0.09)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	count			2	2			2	2			2	2			2	2			2	2			2	2			2	2			2	2
TEfus+	TC5	time			14 (12, 15)	14 (12, 15)			14 (12, 15)	14 (12, 15)			14 (12, 15)	14 (12, 15)			14 (12, 15)	14 (12, 15)			14 (12, 15)	14 (12, 15)			14 (12, 15)	14 (12, 15)			14 (12, 15)	14 (12, 15)			14 (12, 15)	14 (12, 15)
TEfus+	TC5	n			1 (1, 1)	2 (2, 3)			2 (1, 2)	10 (9, 10)			0 (0, 0)	1 (1, 1)			0 (0, 0)	0 (0, 1)			1 (0, 2)	0 (0, 1)			1 (1, 1)	10 (9, 10)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	post_p			0.57 (0.57, 0.57)	0.57 (0.52, 0.62)			0.54 (0.53, 0.56)	0.72 (0.7, 0.74)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	0.52 (0.52, 0.52)			0.57 (0.57, 0.57)	0.54 (0.54, 0.54)			0.52 (0.51, 0.54)	0.82 (0.75, 0.89)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	r_prob			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	rate			0 (0, 0)	0.126 (0.025, 0.227)			0 (0, 0)	0.032 (0.006, 0.058)			NA (NA, NA)	0.21 (0.184, 0.235)			NA (NA, NA)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.074 (0.015, 0.133)	0.065 (0.05, 0.08)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC1	count		5		5		5		5		5		5		5		5		5		5		5		5		5		5		5		5
PI3K+	TC1	time		22 (14, 24)		22 (14, 24)		22 (14, 24)		22 (14, 24)		22 (14, 24)		22 (14, 24)		22 (14, 24)		22 (14, 24)		22 (14, 24)		22 (14, 24)		22 (14, 24)		22 (14, 24)		22 (14, 24)		22 (14, 24)		22 (14, 24)		22 (14, 24)
PI3K+	TC1	n		7 (5, 13)		3 (0, 7)		14 (3, 21)		10 (4, 11)		0 (0, 0)		0 (0, 0)		0 (0, 1)		0 (0, 1)		0 (0, 2)		2 (0, 3)		0 (0, 0)		4 (3, 6)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	post_p		0.76 (0.67, 0.83)		0.7 (0.6, 0.78)		0.75 (0.63, 0.84)		0.71 (0.59, 0.9)		NA (NA, NA)		NA (NA, NA)		0.57 (0.54, 0.59)		0.55 (0.55, 0.55)		NA (NA, NA)		0.62 (0.58, 0.66)		NA (NA, NA)		0.7 (0.56, 0.71)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC1	r_prob		0.22 (0.22, 0.22)		0.22 (0.22, 0.22)		0.13 (0.13, 0.13)		0.09 (0.09, 0.09)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.14 (0.14, 0.14)		0.14 (0.14, 0.14)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.092 (0.052, 0.105)		0.063 (0.061, 0.084)		0.072 (0.055, 0.103)		0.097 (0.061, 0.129)		NA (NA, NA)		NA (NA, NA)		0 (0, 0)		0.15 (0.099, 0.201)		0.114 (0.109, 0.119)		0.065 (0.033, 0.757)		NA (NA, NA)		0.085 (0.081, 0.114)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	count		5		5		5		5		5		5		5		5		5		5		5		5		5		5		5		5
PI3K+	TC2	time		14 (12, 18)		14 (12, 18)		14 (12, 18)		14 (12, 18)		14 (12, 18)		14 (12, 18)		14 (12, 18)		14 (12, 18)		14 (12, 18)		14 (12, 18)		14 (12, 18)		14 (12, 18)		14 (12, 18)		14 (12, 18)		14 (12, 18)		14 (12, 18)
PI3K+	TC2	n		5 (1, 7)		2 (0, 3)		4 (4, 7)		5 (3, 6)		0 (0, 1)		1 (0, 3)		0 (0, 2)		0 (0, 0)		0 (0, 2)		3 (1, 4)		0 (0, 0)		4 (2, 7)		0 (0, 0)		0 (0, 0)		0 (0, 1)		0 (0, 1)
PI3K+	TC2	post_p		0.72 (0.61, 0.76)		0.58 (0.56, 0.6)		0.66 (0.54, 0.86)		0.6 (0.56, 0.75)		NA (NA, NA)		0.54 (0.52, 0.55)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.54 (0.53, 0.56)		NA (NA, NA)		0.57 (0.54, 0.75)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.046 (0.01, 0.084)		0.066 (0.055, 0.071)		0.047 (0.037, 0.097)		0.061 (0.019, 0.153)		0 (0, 0)		0 (0, 0.118)		0.336 (0.067, 0.606)		NA (NA, NA)		0 (0, 0)		0 (0, 0.052)		NA (NA, NA)		0.076 (0.044, 0.111)		NA (NA, NA)		NA (NA, NA)		0 (0, 0)		0 (0, 0)
PI3K+	TC3	count		9		9		9		9		9		9		9		9		9		9		9		9		9		9		9		9
PI3K+	TC3	time		15 (14, 19)		15 (14, 19)		15 (14, 19)		15 (14, 19)		15 (14, 19)		15 (14, 19)		15 (14, 19)		15 (14, 19)		15 (14, 19)		15 (14, 19)		15 (14, 19)		15 (14, 19)		15 (14, 19)		15 (14, 19)		15 (14, 19)		15 (14, 19)
PI3K+	TC3	n		8 (3, 10)		1 (0, 3)		5 (2, 9)		4 (2, 9)		0 (0, 0)		3 (0, 5)		0 (0, 2)		2 (1, 2)		0 (0, 0)		1 (0, 2)		0 (0, 0)		4 (2, 8)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC3	post_p		0.75 (0.62, 0.84)		0.56 (0.51, 0.77)		0.69 (0.55, 0.76)		0.71 (0.59, 0.82)		NA (NA, NA)		0.62 (0.53, 0.76)		0.63 (0.54, 0.64)		0.55 (0.51, 0.57)		0.58 (0.58, 0.58)		0.56 (0.56, 0.56)		NA (NA, NA)		0.67 (0.55, 0.85)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.065 (0.052, 0.076)		0 (0, 0.142)		0.071 (0.036, 0.124)		0.052 (0.016, 0.071)		NA (NA, NA)		0.029 (0, 0.047)		0 (0, 0.062)		0 (0, 0.059)		0.092 (0.092, 0.092)		0.101 (0, 0.238)		NA (NA, NA)		0.061 (0, 0.078)		0.212 (0.212, 0.212)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	count		12		12		12		12		12		12		12		12		12		12		12		12		12		12		12		12
PI3K+	TC4	time		16 (13, 22)		16 (13, 22)		16 (13, 22)		16 (13, 22)		16 (13, 22)		16 (13, 22)		16 (13, 22)		16 (13, 22)		16 (13, 22)		16 (13, 22)		16 (13, 22)		16 (13, 22)		16 (13, 22)		16 (13, 22)		16 (13, 22)		16 (13, 22)
PI3K+	TC4	n		6 (3, 14)		2 (0, 4)		6 (3, 9)		3 (2, 6)		0 (0, 0)		1 (0, 3)		0 (0, 1)		2 (0, 3)		0 (0, 2)		2 (0, 3)		0 (0, 0)		3 (1, 5)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC4	post_p		0.72 (0.53, 0.86)		0.62 (0.51, 0.82)		0.78 (0.7, 0.89)		0.71 (0.51, 0.78)		NA (NA, NA)		0.56 (0.51, 0.68)		0.56 (0.54, 0.6)		0.59 (0.54, 0.69)		0.57 (0.57, 0.57)		0.6 (0.56, 0.61)		NA (NA, NA)		0.56 (0.5, 0.73)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.069 (0.019, 0.11)		0.067 (0, 0.09)		0.053 (0.031, 0.068)		0.071 (0, 0.16)		NA (NA, NA)		0 (0, 0.079)		0 (0, 0)		0 (0, 0.078)		0.155 (0, 6.301)		0.056 (0, 0.233)		NA (NA, NA)		0.073 (0, 0.124)		NA (NA, NA)		NA (NA, NA)		0.124 (0.124, 0.124)		NA (NA, NA)
PI3K+	TC5	count		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2
PI3K+	TC5	time		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)		15 (13, 17)
PI3K+	TC5	n		12 (9, 16)		6 (4, 8)		6 (4, 7)		5 (5, 5)		0 (0, 0)		0 (0, 1)		0 (0, 1)		0 (0, 0)		1 (1, 1)		0 (0, 1)		0 (0, 0)		4 (4, 4)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	post_p		0.77 (0.74, 0.8)		0.7 (0.65, 0.75)		0.64 (0.58, 0.7)		0.66 (0.59, 0.72)		NA (NA, NA)		0.6 (0.6, 0.6)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0.66 (0.65, 0.68)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	r_prob		0.38 (0.38, 0.38)		0.38 (0.38, 0.38)		0.33 (0.33, 0.33)		0.38 (0.38, 0.38)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	rate		0.072 (0.044, 0.1)		0.087 (0.06, 0.114)		0.074 (0.055, 0.094)		0.113 (0.063, 0.163)		NA (NA, NA)		0 (0, 0)		0 (0, 0)		NA (NA, NA)		0.155 (0.113, 0.198)		0.169 (0.169, 0.169)		NA (NA, NA)		0.088 (0.082, 0.093)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)

Futility:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC1	count	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7
all	TC1	time	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)
all	TC1	n	17 (12, 22)	3 (2, 5)	2 (1, 2)	1 (1, 3)	3 (2, 6)	1 (1, 4)	0 (0, 1)	1 (0, 3)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 2)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.33 (0.17, 0.41)	0.45 (0.45, 0.47)	0.45 (0.44, 0.48)	0.43 (0.36, 0.44)	0.4 (0.32, 0.49)	0.39 (0.37, 0.47)	0.46 (0.44, 0.49)	0.48 (0.47, 0.48)	0.48 (0.48, 0.48)	NA (NA, NA)	0.42 (0.42, 0.42)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.48 (0.47, 0.49)	0.42 (0.42, 0.42)	NA (NA, NA)	0.46 (0.46, 0.46)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.39 (0.36, 0.42)	0.46 (0.42, 0.49)	0.49 (0.49, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)	0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.153 (0.103, 0.209)	0.147 (0.055, 0.205)	0.203 (0, 1.074)	0.286 (0, 0.972)	0.348 (0.176, 0.48)	0.224 (0.052, 1.218)	0.856 (0.171, 1.541)	0.152 (0.031, 0.224)	0 (0, 0)	NA (NA, NA)	0.541 (0.417, 0.664)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0.292 (0.058, 0.408)	NA (NA, NA)	1.692 (0.338, 3.046)	0.364 (0.364, 0.364)	0 (0, 0)	NA (NA, NA)	3.072 (1.696, 4.449)	0.13 (0.026, 0.234)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
all	TC2	time	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)	5 (3, 5)
all	TC2	n	7 (6, 9)	1 (0, 2)	0 (0, 1)	0 (0, 0)	3 (1, 3)	1 (0, 3)	1 (0, 2)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (1, 2)	0 (0, 0)	2 (1, 2)	0 (0, 2)	0 (0, 0)	0 (0, 0)	5 (4, 7)	1 (0, 3)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.41 (0.33, 0.47)	0.45 (0.41, 0.49)	NA (NA, NA)	NA (NA, NA)	0.47 (0.45, 0.48)	0.38 (0.38, 0.38)	0.44 (0.44, 0.44)	0.38 (0.38, 0.38)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.4 (0.38, 0.42)	NA (NA, NA)	0.49 (0.49, 0.5)	0.42 (0.42, 0.42)	NA (NA, NA)	NA (NA, NA)	0.43 (0.39, 0.46)	0.47 (0.46, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)	0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.223 (0.101, 0.325)	0.134 (0.027, 0.241)	0 (0, 0)	NA (NA, NA)	0.382 (0.076, 0.688)	0.139 (0.028, 0.25)	0.354 (0.336, 0.372)	0.833 (0.833, 0.833)	2.831 (2.831, 2.831)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.231 (0.046, 0.985)	NA (NA, NA)	0 (0, 0.146)	0.454 (0.454, 0.454)	NA (NA, NA)	NA (NA, NA)	0.307 (0.113, 0.328)	0.101 (0.02, 0.181)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC5	time	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)	10 (10, 11)
all	TC5	n	12 (6, 15)	6 (5, 11)	3 (2, 4)	4 (2, 6)	2 (1, 4)	4 (3, 4)	0 (0, 1)	6 (3, 6)	2 (2, 4)	0 (0, 0)	1 (0, 3)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	2 (0, 3)	2 (1, 4)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	post_p	0.26 (0.15, 0.36)	0.35 (0.33, 0.45)	0.45 (0.43, 0.46)	0.35 (0.23, 0.42)	0.37 (0.35, 0.42)	0.37 (0.28, 0.43)	0.44 (0.44, 0.44)	0.33 (0.18, 0.44)	0.4 (0.28, 0.45)	NA (NA, NA)	0.47 (0.45, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.46 (0.46, 0.46)	0.48 (0.48, 0.48)	NA (NA, NA)	0.43 (0.43, 0.43)	NA (NA, NA)	NA (NA, NA)	0.48 (0.38, 0.49)	0.43 (0.4, 0.47)	0.36 (0.36, 0.36)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	rate	0.159 (0.143, 0.185)	0.21 (0.155, 0.258)	0.215 (0.054, 0.293)	0.155 (0.143, 0.6)	1.283 (0.273, 2.301)	0.249 (0.11, 0.865)	2.555 (2.555, 2.555)	0.245 (0.148, 0.269)	0.172 (0.131, 0.214)	NA (NA, NA)	0.187 (0.113, 0.26)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.133 (0.133, 0.133)	0 (0, 0)	NA (NA, NA)	0.975 (0.862, 1.089)	NA (NA, NA)	NA (NA, NA)	0.136 (0.122, 0.878)	0.203 (0.1, 0.471)	0.17 (0.17, 0.17)	NA (NA, NA)	0.28 (0.056, 0.505)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	count	131	131	131	131					131	131	131	131
AR- & TP53-	TC1	time	13 (6, 29)	13 (6, 29)	13 (6, 29)	13 (6, 29)					13 (6, 29)	13 (6, 29)	13 (6, 29)	13 (6, 29)
AR- & TP53-	TC1	n	24 (16, 47)	5 (2, 13)	1 (0, 3)	2 (0, 6)					3 (0, 7)	0 (0, 0)	2 (0, 5)	0 (0, 3)
AR- & TP53-	TC1	post_p	0.32 (0.12, 0.46)	0.39 (0.2, 0.49)	0.43 (0.28, 0.49)	0.4 (0.28, 0.48)					0.39 (0.24, 0.47)	NA (NA, NA)	0.41 (0.27, 0.48)	0.4 (0.29, 0.48)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.126 (0.101, 0.163)	0.155 (0.102, 0.51)	0.181 (0, 0.681)	0.195 (0.096, 0.601)					0.147 (0.074, 0.777)	0 (0, 0)	0.169 (0.08, 0.6)	0.202 (0.02, 1.006)
AR- & TP53-	TC2	count	103	103	103	103					103	103	103	103
AR- & TP53-	TC2	time	18 (11, 33)	18 (11, 33)	18 (11, 33)	18 (11, 33)					18 (11, 33)	18 (11, 33)	18 (11, 33)	18 (11, 33)
AR- & TP53-	TC2	n	21 (9, 47)	4 (2, 12)	1 (0, 3)	2 (0, 6)					5 (2, 9)	0 (0, 0)	2 (0, 6)	1 (0, 3)
AR- & TP53-	TC2	post_p	0.33 (0.1, 0.47)	0.36 (0.18, 0.47)	0.42 (0.32, 0.48)	0.4 (0.24, 0.48)					0.38 (0.21, 0.46)	NA (NA, NA)	0.41 (0.27, 0.49)	0.42 (0.34, 0.48)
AR- & TP53-	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC2	rate	0.131 (0.106, 0.201)	0.168 (0.116, 0.482)	0.178 (0.063, 0.781)	0.18 (0.11, 0.54)					0.13 (0.076, 0.27)	NA (NA, NA)	0.134 (0.072, 0.613)	0.181 (0.067, 1.45)
AR- & TP53-	TC3	count	1	1	1	1					1	1	1	1
AR- & TP53-	TC3	time	11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)					11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)
AR- & TP53-	TC3	n	13 (13, 13)	3 (3, 3)	1 (1, 1)	1 (1, 1)					6 (6, 6)	0 (0, 0)	2 (2, 2)	0 (0, 0)
AR- & TP53-	TC3	post_p	0.33 (0.33, 0.33)	0.47 (0.47, 0.47)	0.42 (0.42, 0.42)	0.44 (0.44, 0.44)					0.48 (0.48, 0.48)	NA (NA, NA)	0.39 (0.39, 0.39)	NA (NA, NA)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.167 (0.167, 0.167)	0.096 (0.096, 0.096)	0.241 (0.241, 0.241)	0.28 (0.28, 0.28)					0.05 (0.05, 0.05)	NA (NA, NA)	0.104 (0.104, 0.104)	NA (NA, NA)
AR- & TP53-	TC4	count	2	2	2	2					2	2	2	2
AR- & TP53-	TC4	time	17 (15, 19)	17 (15, 19)	17 (15, 19)	17 (15, 19)					17 (15, 19)	17 (15, 19)	17 (15, 19)	17 (15, 19)
AR- & TP53-	TC4	n	14 (13, 15)	5 (3, 7)	2 (0, 4)	2 (2, 3)					8 (5, 11)	0 (0, 0)	4 (1, 8)	1 (0, 2)
AR- & TP53-	TC4	post_p	0.25 (0.09, 0.41)	0.23 (0.16, 0.3)	0.42 (0.42, 0.42)	0.34 (0.32, 0.36)					0.39 (0.35, 0.43)	NA (NA, NA)	0.46 (0.46, 0.46)	0.44 (0.44, 0.44)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.139 (0.119, 0.158)	0.286 (0.2, 0.371)	0.084 (0.084, 0.084)	0.285 (0.157, 0.413)					0.124 (0.115, 0.133)	NA (NA, NA)	0.036 (0.036, 0.036)	0.048 (0.048, 0.048)
AR- & TP53-	TC5	count	101	101	101	101					101	101	101	101
AR- & TP53-	TC5	time	20 (11, 33)	20 (11, 33)	20 (11, 33)	20 (11, 33)					20 (11, 33)	20 (11, 33)	20 (11, 33)	20 (11, 33)
AR- & TP53-	TC5	n	15 (8, 32)	7 (4, 14)	1 (0, 3)	4 (2, 9)					4 (1, 8)	0 (0, 0)	3 (0, 6)	1 (0, 3)
AR- & TP53-	TC5	post_p	0.3 (0.1, 0.47)	0.36 (0.18, 0.49)	0.43 (0.35, 0.49)	0.37 (0.19, 0.47)					0.36 (0.16, 0.47)	NA (NA, NA)	0.39 (0.19, 0.48)	0.43 (0.33, 0.48)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.138 (0.113, 0.213)	0.15 (0.106, 0.266)	0.184 (0.068, 0.6)	0.162 (0.096, 0.394)					0.153 (0.093, 0.493)	NA (NA, NA)	0.151 (0.08, 0.399)	0.147 (0.039, 0.542)
HRD+	TC1	count									26	26	26	26	26	26	26	26									26	26	26	26	26	26	26	26
HRD+	TC1	time									32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)									32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)	32 (28, 35)
HRD+	TC1	n									10 (6, 17)	0 (0, 0)	7 (2, 14)	2 (1, 6)	0 (0, 0)	2 (0, 3)	0 (0, 0)	1 (0, 3)									3 (2, 6)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.28 (0.16, 0.45)	NA (NA, NA)	0.37 (0.17, 0.46)	0.4 (0.33, 0.45)	NA (NA, NA)	0.43 (0.37, 0.47)	NA (NA, NA)	0.4 (0.34, 0.49)									0.29 (0.19, 0.48)	NA (NA, NA)	0.45 (0.38, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.123 (0.087, 0.15)	NA (NA, NA)	0.123 (0.087, 0.289)	0.137 (0.088, 0.414)	0.168 (0.168, 0.168)	0.19 (0.086, 0.71)	0.136 (0.136, 0.136)	0.193 (0.074, 0.713)									0.18 (0.092, 0.26)	0.436 (0.436, 0.436)	0.259 (0.104, 0.955)	0.319 (0.064, 0.574)	0.452 (0, 1.745)	0.108 (0.083, 0.134)	0.241 (0.241, 0.241)	0.333 (0.333, 0.333)
HRD+	TC2	count									31	31	31	31	31	31	31	31									31	31	31	31	31	31	31	31
HRD+	TC2	time									34 (26, 36)	34 (26, 36)	34 (26, 36)	34 (26, 36)	34 (26, 36)	34 (26, 36)	34 (26, 36)	34 (26, 36)									34 (26, 36)	34 (26, 36)	34 (26, 36)	34 (26, 36)	34 (26, 36)	34 (26, 36)	34 (26, 36)	34 (26, 36)
HRD+	TC2	n									11 (6, 13)	0 (0, 0)	6 (2, 8)	3 (1, 5)	0 (0, 0)	2 (0, 4)	0 (0, 0)	1 (0, 3)									4 (2, 7)	0 (0, 0)	0 (0, 2)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.28 (0.14, 0.47)	NA (NA, NA)	0.34 (0.2, 0.47)	0.38 (0.29, 0.46)	NA (NA, NA)	0.42 (0.38, 0.48)	0.46 (0.44, 0.49)	0.43 (0.3, 0.48)									0.33 (0.21, 0.45)	NA (NA, NA)	0.45 (0.42, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.117 (0.092, 0.174)	0.3 (0.214, 0.387)	0.127 (0.08, 0.213)	0.135 (0.077, 0.324)	0.92 (0.92, 0.92)	0.132 (0.072, 0.318)	0.346 (0.185, 0.745)	0.224 (0.099, 1.191)									0.138 (0.093, 0.474)	NA (NA, NA)	0.2 (0.076, 0.381)	0.279 (0.043, 0.591)	0 (0, 0.209)	0.089 (0.089, 0.089)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	count									34	34	34	34	34	34	34	34									34	34	34	34	34	34	34	34
HRD+	TC5	time									32 (25, 36)	32 (25, 36)	32 (25, 36)	32 (25, 36)	32 (25, 36)	32 (25, 36)	32 (25, 36)	32 (25, 36)									32 (25, 36)	32 (25, 36)	32 (25, 36)	32 (25, 36)	32 (25, 36)	32 (25, 36)	32 (25, 36)	32 (25, 36)
HRD+	TC5	n									10 (5, 15)	0 (0, 0)	6 (3, 9)	3 (0, 6)	0 (0, 0)	2 (0, 3)	0 (0, 0)	1 (0, 4)									3 (1, 6)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	post_p									0.27 (0.11, 0.42)	NA (NA, NA)	0.33 (0.2, 0.47)	0.4 (0.28, 0.47)	NA (NA, NA)	0.42 (0.29, 0.48)	NA (NA, NA)	0.41 (0.32, 0.44)									0.35 (0.24, 0.48)	NA (NA, NA)	0.44 (0.41, 0.45)	NA (NA, NA)	0.44 (0.44, 0.44)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	rate									0.131 (0.088, 0.236)	0.187 (0.158, 0.217)	0.147 (0.078, 0.263)	0.123 (0.077, 0.254)	0.044 (0.009, 0.08)	0.198 (0.099, 0.385)	0 (0, 0)	0.238 (0.094, 0.625)									0.168 (0.095, 0.275)	0.298 (0.298, 0.298)	0.275 (0.057, 3.804)	0.276 (0.055, 0.497)	0.073 (0, 0.29)	1.358 (1.358, 1.358)	0.834 (0.834, 0.834)	NA (NA, NA)
TP53+	TC1	count					40	40	40	40					40	40	40	40					40	40	40	40					40	40	40	40
TP53+	TC1	time					20 (15, 33)	20 (15, 33)	20 (15, 33)	20 (15, 33)					20 (15, 33)	20 (15, 33)	20 (15, 33)	20 (15, 33)					20 (15, 33)	20 (15, 33)	20 (15, 33)	20 (15, 33)					20 (15, 33)	20 (15, 33)	20 (15, 33)	20 (15, 33)
TP53+	TC1	n					8 (4, 13)	6 (3, 12)	2 (1, 4)	5 (2, 9)					0 (0, 0)	1 (0, 2)	0 (0, 0)	1 (0, 2)					0 (0, 1)	0 (0, 0)	6 (3, 10)	3 (1, 7)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.35 (0.22, 0.46)	0.38 (0.16, 0.49)	0.42 (0.3, 0.49)	0.34 (0.15, 0.46)					NA (NA, NA)	0.43 (0.36, 0.49)	NA (NA, NA)	0.44 (0.37, 0.5)					0.42 (0.34, 0.48)	NA (NA, NA)	0.36 (0.21, 0.48)	0.35 (0.21, 0.45)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.159 (0.108, 0.245)	0.165 (0.103, 0.27)	0.208 (0.099, 1.057)	0.168 (0.115, 0.469)					0.086 (0.017, 0.155)	0.144 (0.012, 0.576)	NA (NA, NA)	0.147 (0.005, 2.408)					0.124 (0, 0.851)	0.352 (0.352, 0.352)	0.151 (0.105, 0.302)	0.201 (0.133, 0.865)					0 (0, 0)	0.989 (0.403, 1.576)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	count					41	41	41	41					41	41	41	41					41	41	41	41					41	41	41	41
TP53+	TC2	time					21 (14, 30)	21 (14, 30)	21 (14, 30)	21 (14, 30)					21 (14, 30)	21 (14, 30)	21 (14, 30)	21 (14, 30)					21 (14, 30)	21 (14, 30)	21 (14, 30)	21 (14, 30)					21 (14, 30)	21 (14, 30)	21 (14, 30)	21 (14, 30)
TP53+	TC2	n					6 (3, 12)	5 (2, 10)	3 (1, 5)	4 (2, 10)					0 (0, 0)	1 (0, 2)	0 (0, 0)	1 (0, 2)					0 (0, 2)	0 (0, 0)	6 (3, 11)	4 (2, 10)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.37 (0.13, 0.49)	0.32 (0.19, 0.45)	0.38 (0.26, 0.47)	0.38 (0.17, 0.47)					NA (NA, NA)	0.43 (0.36, 0.48)	NA (NA, NA)	0.46 (0.4, 0.5)					0.44 (0.34, 0.48)	NA (NA, NA)	0.38 (0.16, 0.48)	0.38 (0.22, 0.47)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.157 (0.111, 0.55)	0.162 (0.103, 0.498)	0.173 (0.116, 0.491)	0.178 (0.112, 0.358)					NA (NA, NA)	0.167 (0.052, 2.27)	0.225 (0.107, 0.343)	0.173 (0.005, 1.163)					0.261 (0, 2.481)	1.24 (1.24, 1.24)	0.147 (0.106, 0.417)	0.159 (0.108, 0.403)					0.144 (0.029, 1.452)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	count					13	13	13	13					13	13	13	13					13	13	13	13					13	13	13	13
TP53+	TC3	time					21 (17, 33)	21 (17, 33)	21 (17, 33)	21 (17, 33)					21 (17, 33)	21 (17, 33)	21 (17, 33)	21 (17, 33)					21 (17, 33)	21 (17, 33)	21 (17, 33)	21 (17, 33)					21 (17, 33)	21 (17, 33)	21 (17, 33)	21 (17, 33)
TP53+	TC3	n					6 (3, 11)	4 (2, 9)	2 (1, 4)	4 (2, 6)					0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 1)					0 (0, 1)	0 (0, 0)	5 (3, 8)	4 (1, 7)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.25 (0.16, 0.43)	0.26 (0.15, 0.47)	0.39 (0.32, 0.49)	0.41 (0.27, 0.45)					NA (NA, NA)	0.45 (0.44, 0.48)	NA (NA, NA)	0.48 (0.41, 0.49)					0.41 (0.38, 0.44)	NA (NA, NA)	0.36 (0.21, 0.46)	0.38 (0.27, 0.5)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.173 (0.12, 0.25)	0.188 (0.125, 0.429)	0.193 (0.011, 0.624)	0.198 (0.109, 0.28)					0 (0, 0)	0.179 (0.039, 1.288)	NA (NA, NA)	0.245 (0.038, 0.796)					0.117 (0.045, 0.64)	0.081 (0.081, 0.081)	0.174 (0.138, 0.331)	0.16 (0.116, 0.424)					0 (0, 0.117)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	count					21	21	21	21					21	21	21	21					21	21	21	21					21	21	21	21
TP53+	TC4	time					24 (19, 32)	24 (19, 32)	24 (19, 32)	24 (19, 32)					24 (19, 32)	24 (19, 32)	24 (19, 32)	24 (19, 32)					24 (19, 32)	24 (19, 32)	24 (19, 32)	24 (19, 32)					24 (19, 32)	24 (19, 32)	24 (19, 32)	24 (19, 32)
TP53+	TC4	n					6 (4, 8)	5 (3, 8)	3 (1, 5)	5 (2, 7)					0 (0, 0)	0 (0, 1)	0 (0, 0)	1 (0, 2)					1 (0, 1)	0 (0, 0)	5 (3, 10)	5 (2, 8)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.35 (0.25, 0.48)	0.36 (0.14, 0.45)	0.43 (0.25, 0.49)	0.35 (0.21, 0.48)					NA (NA, NA)	0.46 (0.41, 0.48)	NA (NA, NA)	0.44 (0.42, 0.49)					0.44 (0.42, 0.47)	NA (NA, NA)	0.32 (0.12, 0.41)	0.37 (0.21, 0.49)					0.47 (0.47, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.142 (0.104, 0.206)	0.211 (0.112, 0.636)	0.178 (0.107, 0.36)	0.203 (0.113, 0.321)					NA (NA, NA)	0.088 (0.026, 0.229)	NA (NA, NA)	0.077 (0, 0.284)					0.232 (0, 0.618)	NA (NA, NA)	0.185 (0.126, 0.364)	0.157 (0.115, 0.26)					0 (0, 0.131)	0.193 (0.193, 0.193)	NA (NA, NA)	0 (0, 0)
TP53+	TC5	count					38	38	38	38					38	38	38	38					38	38	38	38					38	38	38	38
TP53+	TC5	time					24 (13, 32)	24 (13, 32)	24 (13, 32)	24 (13, 32)					24 (13, 32)	24 (13, 32)	24 (13, 32)	24 (13, 32)					24 (13, 32)	24 (13, 32)	24 (13, 32)	24 (13, 32)					24 (13, 32)	24 (13, 32)	24 (13, 32)	24 (13, 32)
TP53+	TC5	n					6 (4, 11)	6 (4, 12)	1 (0, 3)	6 (4, 11)					0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 2)					0 (0, 1)	0 (0, 0)	4 (1, 8)	5 (3, 9)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	post_p					0.36 (0.14, 0.47)	0.35 (0.21, 0.46)	0.4 (0.24, 0.45)	0.33 (0.16, 0.47)					NA (NA, NA)	0.44 (0.39, 0.49)	NA (NA, NA)	0.45 (0.38, 0.5)					0.48 (0.44, 0.49)	0.5 (0.5, 0.5)	0.34 (0.21, 0.47)	0.42 (0.21, 0.49)					NA (NA, NA)	NA (NA, NA)	0.43 (0.43, 0.43)	NA (NA, NA)
TP53+	TC5	r_prob					0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	rate					0.161 (0.109, 0.265)	0.153 (0.119, 0.26)	0.19 (0.111, 0.989)	0.152 (0.119, 0.288)					NA (NA, NA)	0.108 (0, 0.747)	0.204 (0.204, 0.204)	0.106 (0, 1.791)					0.192 (0, 0.807)	0.148 (0.03, 0.267)	0.204 (0.128, 0.596)	0.151 (0.092, 0.411)					0.193 (0.193, 0.193)	0.096 (0.096, 0.096)	1.324 (1.25, 1.398)	NA (NA, NA)
TEfus+	TC1	count			16	16			16	16			16	16			16	16			16	16			16	16			16	16			16	16
TEfus+	TC1	time			22 (19, 32)	22 (19, 32)			22 (19, 32)	22 (19, 32)			22 (19, 32)	22 (19, 32)			22 (19, 32)	22 (19, 32)			22 (19, 32)	22 (19, 32)			22 (19, 32)	22 (19, 32)			22 (19, 32)	22 (19, 32)			22 (19, 32)	22 (19, 32)
TEfus+	TC1	n			2 (0, 4)	3 (1, 6)			2 (1, 4)	4 (2, 9)			3 (0, 6)	1 (0, 2)			0 (0, 0)	0 (0, 2)			2 (0, 4)	2 (1, 4)			5 (4, 10)	4 (1, 7)			0 (0, 2)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.41 (0.33, 0.48)	0.38 (0.28, 0.47)			0.42 (0.33, 0.48)	0.34 (0.26, 0.45)			0.4 (0.2, 0.49)	0.4 (0.32, 0.43)			NA (NA, NA)	0.45 (0.36, 0.46)			0.37 (0.24, 0.48)	0.46 (0.37, 0.49)			0.42 (0.3, 0.48)	0.31 (0.2, 0.41)			0.44 (0.44, 0.48)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.37 (0.37, 0.37)	0.22 (0.22, 0.22)			0.18 (0.18, 0.18)	0.09 (0.09, 0.09)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.18 (0.18, 0.18)	0.14 (0.14, 0.14)			0.12 (0.12, 0.12)	0.07 (0.07, 0.07)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.2 (0.099, 1.139)	0.195 (0.098, 2.167)			0.158 (0.115, 0.488)	0.157 (0.114, 0.321)			0.119 (0.08, 0.44)	0.289 (0.155, 0.6)			NA (NA, NA)	0.193 (0.094, 3.404)			0.192 (0.082, 0.549)	0.139 (0.095, 0.493)			0.125 (0.085, 0.2)	0.212 (0.141, 1.061)			0.407 (0, 2.385)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	count			18	18			18	18			18	18			18	18			18	18			18	18			18	18			18	18
TEfus+	TC2	time			17 (14, 26)	17 (14, 26)			17 (14, 26)	17 (14, 26)			17 (14, 26)	17 (14, 26)			17 (14, 26)	17 (14, 26)			17 (14, 26)	17 (14, 26)			17 (14, 26)	17 (14, 26)			17 (14, 26)	17 (14, 26)			17 (14, 26)	17 (14, 26)
TEfus+	TC2	n			1 (0, 2)	2 (1, 5)			2 (1, 5)	4 (2, 7)			3 (1, 5)	0 (0, 2)			0 (0, 0)	0 (0, 1)			2 (1, 5)	1 (0, 3)			6 (5, 11)	6 (3, 8)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.42 (0.39, 0.5)	0.43 (0.19, 0.48)			0.41 (0.22, 0.46)	0.43 (0.2, 0.49)			0.38 (0.27, 0.48)	0.32 (0.28, 0.34)			NA (NA, NA)	0.42 (0.36, 0.43)			0.43 (0.3, 0.45)	0.44 (0.4, 0.48)			0.38 (0.22, 0.5)	0.4 (0.13, 0.48)			0.4 (0.4, 0.4)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.25 (0.25, 0.25)	0.03 (0.03, 0.03)			0.41 (0.41, 0.41)	0.16 (0.16, 0.16)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.41 (0.41, 0.41)	0.29 (0.29, 0.29)			0.37 (0.37, 0.37)	0.21 (0.21, 0.21)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.223 (0.01, 0.309)	0.166 (0.098, 0.654)			0.159 (0.095, 1.127)	0.137 (0.086, 0.418)			0.141 (0.051, 0.394)	0.143 (0, 0.859)			0.372 (0.372, 0.372)	0.23 (0.071, 0.448)			0.174 (0.121, 0.416)	0.192 (0.124, 0.904)			0.128 (0.087, 0.183)	0.151 (0.103, 0.418)			0.502 (0.048, 1.067)	0 (0, 0)			NA (NA, NA)	0.284 (0.284, 0.284)
TEfus+	TC3	count			1	1			1	1			1	1			1	1			1	1			1	1			1	1			1	1
TEfus+	TC3	time			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)
TEfus+	TC3	n			3 (3, 3)	1 (1, 1)			0 (0, 0)	3 (3, 3)			4 (4, 4)	3 (3, 3)			0 (0, 0)	0 (0, 0)			1 (1, 1)	0 (0, 0)			5 (5, 5)	4 (4, 4)			1 (1, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.35 (0.35, 0.35)	0.35 (0.35, 0.35)			NA (NA, NA)	0.32 (0.32, 0.32)			0.5 (0.5, 0.5)	0.49 (0.49, 0.49)			NA (NA, NA)	NA (NA, NA)			0.4 (0.4, 0.4)	NA (NA, NA)			0.44 (0.44, 0.44)	0.34 (0.34, 0.34)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.211 (0.211, 0.211)	0.492 (0.492, 0.492)			NA (NA, NA)	0.262 (0.262, 0.262)			0.069 (0.069, 0.069)	0.109 (0.109, 0.109)			NA (NA, NA)	NA (NA, NA)			0.301 (0.301, 0.301)	NA (NA, NA)			0.179 (0.179, 0.179)	0.173 (0.173, 0.173)			0 (0, 0)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	count			1	1			1	1			1	1			1	1			1	1			1	1			1	1			1	1
TEfus+	TC4	time			25 (25, 25)	25 (25, 25)			25 (25, 25)	25 (25, 25)			25 (25, 25)	25 (25, 25)			25 (25, 25)	25 (25, 25)			25 (25, 25)	25 (25, 25)			25 (25, 25)	25 (25, 25)			25 (25, 25)	25 (25, 25)			25 (25, 25)	25 (25, 25)
TEfus+	TC4	n			2 (2, 2)	3 (3, 3)			2 (2, 2)	15 (15, 15)			5 (5, 5)	1 (1, 1)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			6 (6, 6)	4 (4, 4)			1 (1, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.32 (0.32, 0.32)	0.28 (0.28, 0.28)			0.43 (0.43, 0.43)	0.39 (0.39, 0.39)			0.3 (0.3, 0.3)	0.43 (0.43, 0.43)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)			0.41 (0.41, 0.41)	0.36 (0.36, 0.36)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.54 (0.54, 0.54)	0.232 (0.232, 0.232)			0.148 (0.148, 0.148)	0.123 (0.123, 0.123)			0.111 (0.111, 0.111)	0.102 (0.102, 0.102)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)			0.159 (0.159, 0.159)	0.217 (0.217, 0.217)			0 (0, 0)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	count			15	15			15	15			15	15			15	15			15	15			15	15			15	15			15	15
TEfus+	TC5	time			19 (12, 28)	19 (12, 28)			19 (12, 28)	19 (12, 28)			19 (12, 28)	19 (12, 28)			19 (12, 28)	19 (12, 28)			19 (12, 28)	19 (12, 28)			19 (12, 28)	19 (12, 28)			19 (12, 28)	19 (12, 28)			19 (12, 28)	19 (12, 28)
TEfus+	TC5	n			1 (0, 4)	4 (1, 7)			1 (0, 4)	6 (3, 9)			3 (0, 5)	1 (0, 3)			0 (0, 0)	1 (0, 2)			2 (0, 4)	2 (0, 3)			4 (2, 6)	5 (2, 9)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	post_p			0.41 (0.36, 0.49)	0.39 (0.19, 0.45)			0.41 (0.31, 0.49)	0.31 (0.21, 0.46)			0.33 (0.16, 0.42)	0.4 (0.3, 0.45)			NA (NA, NA)	0.45 (0.42, 0.46)			0.38 (0.19, 0.45)	0.44 (0.4, 0.48)			0.36 (0.22, 0.47)	0.38 (0.22, 0.45)			0.46 (0.46, 0.46)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	r_prob			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	rate			0.297 (0, 0.737)	0.158 (0.109, 0.37)			0.202 (0.087, 0.389)	0.177 (0.118, 0.305)			0.186 (0.077, 0.753)	0.21 (0.155, 0.467)			NA (NA, NA)	0.158 (0.092, 0.87)			0.18 (0.091, 0.302)	0.205 (0.08, 0.791)			0.161 (0.121, 0.42)	0.14 (0.089, 0.245)			0.136 (0.034, 0.232)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC1	count		28		28		28		28		28		28		28		28		28		28		28		28		28		28		28		28
PI3K+	TC1	time		24 (16, 32)		24 (16, 32)		24 (16, 32)		24 (16, 32)		24 (16, 32)		24 (16, 32)		24 (16, 32)		24 (16, 32)		24 (16, 32)		24 (16, 32)		24 (16, 32)		24 (16, 32)		24 (16, 32)		24 (16, 32)		24 (16, 32)		24 (16, 32)
PI3K+	TC1	n		6 (3, 13)		4 (1, 7)		6 (3, 10)		5 (2, 11)		0 (0, 0)		1 (0, 3)		1 (0, 2)		1 (0, 3)		1 (0, 2)		1 (0, 3)		0 (0, 0)		3 (1, 6)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	post_p		0.31 (0.18, 0.45)		0.38 (0.23, 0.45)		0.36 (0.19, 0.47)		0.36 (0.17, 0.45)		NA (NA, NA)		0.43 (0.33, 0.47)		0.44 (0.41, 0.47)		0.42 (0.36, 0.47)		0.47 (0.36, 0.49)		0.4 (0.27, 0.46)		NA (NA, NA)		0.32 (0.18, 0.5)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC1	r_prob		0.22 (0.22, 0.22)		0.22 (0.22, 0.22)		0.13 (0.13, 0.13)		0.09 (0.09, 0.09)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.14 (0.14, 0.14)		0.14 (0.14, 0.14)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.169 (0.112, 0.405)		0.157 (0.097, 0.326)		0.165 (0.107, 0.293)		0.159 (0.108, 0.354)		0.136 (0.136, 0.136)		0.233 (0.089, 0.438)		0.169 (0.057, 0.756)		0.172 (0.024, 0.96)		0.14 (0.031, 0.521)		0.288 (0.016, 0.948)		0.558 (0.558, 0.558)		0.235 (0.112, 0.792)		NA (NA, NA)		0 (0, 0)		0.181 (0.181, 0.181)		0.29 (0.29, 0.29)
PI3K+	TC2	count		30		30		30		30		30		30		30		30		30		30		30		30		30		30		30		30
PI3K+	TC2	time		20 (17, 30)		20 (17, 30)		20 (17, 30)		20 (17, 30)		20 (17, 30)		20 (17, 30)		20 (17, 30)		20 (17, 30)		20 (17, 30)		20 (17, 30)		20 (17, 30)		20 (17, 30)		20 (17, 30)		20 (17, 30)		20 (17, 30)		20 (17, 30)
PI3K+	TC2	n		6 (2, 11)		3 (0, 7)		7 (3, 10)		4 (2, 9)		0 (0, 0)		1 (0, 4)		1 (0, 3)		0 (0, 2)		1 (0, 2)		1 (0, 2)		0 (0, 0)		4 (3, 8)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	post_p		0.38 (0.16, 0.49)		0.37 (0.23, 0.44)		0.33 (0.19, 0.42)		0.34 (0.22, 0.41)		NA (NA, NA)		0.38 (0.3, 0.46)		0.42 (0.36, 0.47)		0.44 (0.35, 0.5)		0.42 (0.42, 0.46)		0.45 (0.32, 0.49)		NA (NA, NA)		0.34 (0.24, 0.46)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.163 (0.106, 0.258)		0.175 (0.118, 0.373)		0.168 (0.127, 0.355)		0.152 (0.117, 0.34)		0 (0, 0)		0.159 (0.047, 0.558)		0.22 (0.079, 0.632)		0.23 (0.088, 0.469)		0.193 (0, 0.514)		0.17 (0.016, 0.358)		0.62 (0.124, 1.116)		0.148 (0.089, 0.248)		0 (0, 0)		0.373 (0.191, 0.556)		0 (0, 0)		0.584 (0.117, 1.052)
PI3K+	TC3	count		8		8		8		8		8		8		8		8		8		8		8		8		8		8		8		8
PI3K+	TC3	time		18 (15, 26)		18 (15, 26)		18 (15, 26)		18 (15, 26)		18 (15, 26)		18 (15, 26)		18 (15, 26)		18 (15, 26)		18 (15, 26)		18 (15, 26)		18 (15, 26)		18 (15, 26)		18 (15, 26)		18 (15, 26)		18 (15, 26)		18 (15, 26)
PI3K+	TC3	n		8 (5, 12)		2 (2, 4)		4 (2, 6)		4 (2, 5)		0 (0, 0)		2 (1, 2)		0 (0, 1)		1 (1, 2)		0 (0, 2)		0 (0, 3)		0 (0, 0)		5 (2, 9)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC3	post_p		0.35 (0.2, 0.42)		0.35 (0.19, 0.45)		0.24 (0.12, 0.39)		0.34 (0.25, 0.47)		NA (NA, NA)		0.46 (0.46, 0.48)		0.49 (0.49, 0.49)		0.44 (0.4, 0.49)		0.47 (0.45, 0.49)		0.47 (0.47, 0.47)		NA (NA, NA)		0.38 (0.26, 0.48)		0.47 (0.47, 0.47)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.16 (0.125, 0.238)		0.304 (0.142, 0.669)		0.211 (0.161, 0.897)		0.188 (0.119, 0.306)		NA (NA, NA)		0.062 (0, 0.769)		0.032 (0, 0.387)		0.159 (0.056, 0.33)		0.199 (0.04, 0.261)		0.289 (0.143, 0.514)		NA (NA, NA)		0.169 (0.105, 0.262)		0 (0, 0)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	count		9		9		9		9		9		9		9		9		9		9		9		9		9		9		9		9
PI3K+	TC4	time		26 (22, 32)		26 (22, 32)		26 (22, 32)		26 (22, 32)		26 (22, 32)		26 (22, 32)		26 (22, 32)		26 (22, 32)		26 (22, 32)		26 (22, 32)		26 (22, 32)		26 (22, 32)		26 (22, 32)		26 (22, 32)		26 (22, 32)		26 (22, 32)
PI3K+	TC4	n		7 (5, 22)		4 (3, 8)		6 (4, 10)		5 (2, 10)		0 (0, 0)		1 (0, 2)		0 (0, 1)		1 (0, 1)		1 (0, 1)		0 (0, 1)		0 (0, 0)		3 (2, 7)		0 (0, 0)		0 (0, 0)		0 (0, 1)		0 (0, 0)
PI3K+	TC4	post_p		0.34 (0.28, 0.44)		0.34 (0.24, 0.44)		0.38 (0.1, 0.45)		0.4 (0.28, 0.45)		NA (NA, NA)		0.43 (0.37, 0.48)		0.44 (0.42, 0.46)		0.44 (0.4, 0.48)		0.44 (0.42, 0.44)		0.45 (0.36, 0.49)		NA (NA, NA)		0.4 (0.31, 0.47)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.126 (0.114, 0.203)		0.181 (0.122, 0.288)		0.161 (0.128, 0.348)		0.199 (0.12, 0.379)		NA (NA, NA)		0.102 (0.069, 0.306)		0.042 (0.008, 0.21)		0.124 (0.014, 0.333)		0.629 (0.492, 0.868)		0.216 (0.143, 0.257)		NA (NA, NA)		0.185 (0.13, 0.356)		NA (NA, NA)		0 (0, 0)		0.13 (0.079, 0.18)		NA (NA, NA)
PI3K+	TC5	count		40		40		40		40		40		40		40		40		40		40		40		40		40		40		40		40
PI3K+	TC5	time		20 (9, 30)		20 (9, 30)		20 (9, 30)		20 (9, 30)		20 (9, 30)		20 (9, 30)		20 (9, 30)		20 (9, 30)		20 (9, 30)		20 (9, 30)		20 (9, 30)		20 (9, 30)		20 (9, 30)		20 (9, 30)		20 (9, 30)		20 (9, 30)
PI3K+	TC5	n		8 (4, 16)		4 (2, 8)		5 (3, 11)		6 (2, 12)		0 (0, 0)		1 (0, 2)		1 (0, 2)		0 (0, 2)		1 (0, 2)		1 (0, 3)		0 (0, 0)		3 (2, 8)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	post_p		0.4 (0.17, 0.49)		0.39 (0.18, 0.48)		0.38 (0.17, 0.47)		0.34 (0.2, 0.45)		NA (NA, NA)		0.43 (0.31, 0.47)		0.45 (0.37, 0.49)		0.4 (0.28, 0.45)		0.46 (0.43, 0.49)		0.45 (0.32, 0.48)		NA (NA, NA)		0.36 (0.22, 0.49)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	r_prob		0.38 (0.38, 0.38)		0.38 (0.38, 0.38)		0.33 (0.33, 0.33)		0.38 (0.38, 0.38)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	rate		0.139 (0.096, 0.292)		0.162 (0.092, 0.394)		0.153 (0.11, 0.327)		0.17 (0.115, 0.375)		NA (NA, NA)		0.249 (0.024, 2.254)		0.173 (0, 0.386)		0.198 (0.026, 0.88)		0.121 (0, 0.367)		0.168 (0, 0.828)		NA (NA, NA)		0.195 (0.113, 0.7)		NA (NA, NA)		0 (0, 0)		0.096 (0.096, 0.096)		0.191 (0.191, 0.191)