TC3 and TC4 more effective in the HRD+ biomarker signature
| signature | var | Other | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.112, shape = 1.05 |
| all | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 9.9, median = 7.1 | mean = 9.9, median = 7.1 | mean = 8.8, median = 6.3 |
| all | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.13, hr = 0.88 | af = 1.13, hr = 0.88 | af = 1, hr = 1 |
| AR- & TP53- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.096, shape = 1.05 | scale = 0.096, shape = 1.05 | scale = 0.112, shape = 1.05 |
| AR- & TP53- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 10.2, median = 7.4 | mean = 10.2, median = 7.4 | mean = 8.8, median = 6.3 |
| AR- & TP53- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.16, hr = 0.85 | af = 1.16, hr = 0.85 | af = 1, hr = 1 |
| HRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| HRD+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| HRD+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.107, shape = 1.05 | scale = 0.107, shape = 1.05 | scale = 0.112, shape = 1.05 |
| TP53+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 9.2, median = 6.6 | mean = 9.2, median = 6.6 | mean = 8.8, median = 6.3 |
| TP53+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.04, hr = 0.96 | af = 1.04, hr = 0.96 | af = 1, hr = 1 |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.097, shape = 1.05 | scale = 0.097, shape = 1.05 | scale = 0.112, shape = 1.05 |
| TEfus+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 10.1, median = 7.3 | mean = 10.1, median = 7.3 | mean = 8.8, median = 6.3 |
| TEfus+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.15, hr = 0.87 | af = 1.15, hr = 0.87 | af = 1, hr = 1 |
| PI3K+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.104, shape = 1.05 | scale = 0.104, shape = 1.05 | scale = 0.112, shape = 1.05 |
| PI3K+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 9.4, median = 6.8 | mean = 9.4, median = 6.8 | mean = 8.8, median = 6.3 |
| PI3K+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.07, hr = 0.93 | af = 1.07, hr = 0.93 | af = 1, hr = 1 |
| subtype | var | Other | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| —– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| —– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| —– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| —-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| —-+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| —-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| —+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| —+- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| —+- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| —++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| —++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| —++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| –+– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| –+– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| –+– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| –+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| –+-+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| –+-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| –++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| –++- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| –++- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| –+++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| –+++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| –+++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+— | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -+— | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| -+— | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| -+–+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -+–+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| -+–+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| -+-+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -+-+- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| -+-+- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| -+-++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -+-++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| -+-++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| -++– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -++– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| -++– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| -++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -++-+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| -++-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| -+++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -+++- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| -+++- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| -++++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -++++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| -++++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| +—- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +—- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +—- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +—+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +—+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +—+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +–+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +–+- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +–+- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +–++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +–++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +–++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-+– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +-+– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +-+– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +-+-+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +-+-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +-++- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +-++- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-+++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +-+++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +-+++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| ++— | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| ++— | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| ++— | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| ++–+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| ++–+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| ++–+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| ++-+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| ++-+- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| ++-+- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| ++-++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| ++-++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| ++-++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| +++– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +++– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| +++– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| +++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +++-+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| +++-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| ++++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| ++++- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| ++++- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| +++++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +++++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| +++++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
|
|
|
|
|
|
| char | overall | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|
| err_sign | 0.3286573 | 0.0761523 | 0.0641283 | 0.0821643 | 0.1022044 | 0.0420842 |
| err_type | 0.4228457 | 0.0761523 | 0.0641283 | 0.1382766 | 0.1663327 | 0.0420842 |
| pow_sign | 0.8036072 | 0.0000000 | 0.0000000 | 0.5511022 | 0.5631263 | 0.0000000 |
| pow_type | 0.8737475 | 0.0000000 | 0.0000000 | 0.6332665 | 0.6653307 | 0.0000000 |
| signature | var | Control | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| all | graduation | 0 | 6 | 1 | 14 | 15 | 3 |
| all | futility | 0 | 7 | 3 | 0 | 0 | 4 |
| all | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| all | n | 366 (335, 406) | 160 (100, 225) | 160 (108, 219) | 163 (112, 217) | 159 (110, 217) | 165 (105, 224) |
| all | n_unique | 335 (306, 373) | 148 (92, 210) | 146 (98, 202) | 150 (103, 200) | 146 (99, 201) | 152 (96, 208) |
| all | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) |
| all | time_stop | NA (NA, NA) | 5 (3, 7) | 4 (3, 5) | 7 (6, 9) | 8 (6, 13) | 10 (7, 11) |
| all | post_p | NA (NA, NA) | 0.45 (0.07, 0.87) | 0.46 (0.09, 0.86) | 1 (0.91, 1) | 1 (0.92, 1) | 0.47 (0.07, 0.87) |
| all | rate | 0.112 (0.104, 0.12) | 0.113 (0.1, 0.129) | 0.113 (0.102, 0.127) | 0.084 (0.073, 0.095) | 0.084 (0.072, 0.095) | 0.113 (0.102, 0.128) |
| AR- & TP53- | graduation | 0 | 20 | 24 | 39 | 50 | 13 |
| AR- & TP53- | futility | 0 | 131 | 103 | 1 | 2 | 101 |
| AR- & TP53- | max_n | 0 | 53 | 31 | 41 | 46 | 44 |
| AR- & TP53- | n | 217 (191, 251) | 87 (29, 150) | 77 (31, 139) | 89 (47, 143) | 88 (45, 146) | 85 (33, 146) |
| AR- & TP53- | n_unique | 201 (175, 232) | 80 (28, 140) | 71 (29, 129) | 82 (43, 135) | 81 (39, 137) | 79 (30, 138) |
| AR- & TP53- | time_trial | 36 (36, 36) | 36 (10, 36) | 36 (14, 36) | 36 (36, 36) | 36 (32, 36) | 36 (16, 36) |
| AR- & TP53- | time_stop | NA (NA, NA) | 12 (6, 28) | 17 (10, 31) | 14 (9, 25) | 14 (10, 27) | 19 (11, 33) |
| AR- & TP53- | post_p | NA (NA, NA) | 0.41 (0.07, 0.85) | 0.4 (0.08, 0.87) | 1 (0.88, 1) | 0.99 (0.87, 1) | 0.44 (0.08, 0.87) |
| AR- & TP53- | rate | 0.113 (0.102, 0.123) | 0.115 (0.098, 0.14) | 0.114 (0.098, 0.14) | 0.076 (0.06, 0.093) | 0.077 (0.058, 0.093) | 0.114 (0.098, 0.14) |
| HRD+ | graduation | 0 | 0 | 1 | 275 | 281 | 0 |
| HRD+ | futility | 0 | 26 | 31 | 0 | 0 | 34 |
| HRD+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| HRD+ | n | 60 (48, 72) | 21 (10, 35) | 23 (13, 35) | 34 (25, 56) | 32 (25, 54) | 22 (14, 35) |
| HRD+ | n_unique | 55 (44, 67) | 19 (10, 32) | 20 (11, 32) | 31 (22, 51) | 29 (21, 49) | 20 (12, 32) |
| HRD+ | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 33 (19, 36) | 32 (19, 36) | 36 (36, 36) |
| HRD+ | time_stop | NA (NA, NA) | 32 (28, 35) | 34 (26, 36) | 23 (17, 33) | 24 (17, 32) | 32 (25, 36) |
| HRD+ | post_p | NA (NA, NA) | 0.31 (0.08, 0.75) | 0.32 (0.07, 0.73) | 1 (1, 1) | 1 (1, 1) | 0.32 (0.06, 0.73) |
| HRD+ | rate | 0.114 (0.093, 0.137) | 0.114 (0.082, 0.165) | 0.116 (0.085, 0.156) | 0.036 (0.025, 0.047) | 0.035 (0.025, 0.047) | 0.114 (0.086, 0.161) |
| TP53+ | graduation | 0 | 5 | 2 | 7 | 8 | 3 |
| TP53+ | futility | 0 | 40 | 41 | 13 | 21 | 38 |
| TP53+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| TP53+ | n | 122 (106, 139) | 58 (34, 79) | 63 (41, 82) | 56 (35, 77) | 55 (34, 75) | 61 (37, 81) |
| TP53+ | n_unique | 110 (96, 126) | 53 (31, 72) | 57 (37, 75) | 51 (31, 70) | 50 (30, 69) | 56 (34, 75) |
| TP53+ | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) |
| TP53+ | time_stop | NA (NA, NA) | 20 (15, 33) | 20 (14, 30) | 20 (15, 29) | 22 (17, 30) | 23 (12, 31) |
| TP53+ | post_p | NA (NA, NA) | 0.46 (0.08, 0.87) | 0.48 (0.12, 0.86) | 0.64 (0.21, 0.95) | 0.68 (0.19, 0.97) | 0.46 (0.09, 0.83) |
| TP53+ | rate | 0.111 (0.097, 0.128) | 0.115 (0.093, 0.141) | 0.113 (0.095, 0.138) | 0.104 (0.083, 0.128) | 0.103 (0.084, 0.13) | 0.114 (0.095, 0.14) |
| TEfus+ | graduation | 0 | 2 | 2 | 6 | 9 | 2 |
| TEfus+ | futility | 0 | 16 | 18 | 1 | 1 | 15 |
| TEfus+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| TEfus+ | n | 115 (99, 133) | 54 (35, 73) | 58 (41, 79) | 56 (39, 74) | 56 (38, 73) | 58 (38, 76) |
| TEfus+ | n_unique | 104 (89, 119) | 48 (31, 66) | 52 (37, 72) | 52 (34, 67) | 51 (33, 66) | 53 (35, 69) |
| TEfus+ | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) |
| TEfus+ | time_stop | NA (NA, NA) | 20 (16, 32) | 16 (15, 26) | 12 (11, 19) | 18 (14, 20) | 18 (12, 28) |
| TEfus+ | post_p | NA (NA, NA) | 0.46 (0.08, 0.85) | 0.42 (0.1, 0.87) | 0.93 (0.61, 1) | 0.93 (0.55, 1) | 0.41 (0.1, 0.86) |
| TEfus+ | rate | 0.112 (0.098, 0.129) | 0.113 (0.093, 0.145) | 0.114 (0.096, 0.137) | 0.083 (0.067, 0.105) | 0.083 (0.065, 0.105) | 0.114 (0.095, 0.139) |
| PI3K+ | graduation | 0 | 5 | 5 | 9 | 12 | 2 |
| PI3K+ | futility | 0 | 28 | 30 | 8 | 9 | 40 |
| PI3K+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| PI3K+ | n | 121 (104, 136) | 54 (32, 79) | 56 (35, 78) | 54 (34, 75) | 53 (33, 75) | 64 (42, 88) |
| PI3K+ | n_unique | 109 (95, 124) | 49 (29, 71) | 50 (31, 72) | 49 (30, 68) | 48 (30, 68) | 59 (39, 80) |
| PI3K+ | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) |
| PI3K+ | time_stop | NA (NA, NA) | 24 (15, 31) | 19 (15, 30) | 17 (15, 24) | 21 (14, 31) | 19 (9, 30) |
| PI3K+ | post_p | NA (NA, NA) | 0.47 (0.11, 0.88) | 0.48 (0.1, 0.84) | 0.77 (0.37, 0.98) | 0.76 (0.33, 0.98) | 0.48 (0.1, 0.86) |
| PI3K+ | rate | 0.113 (0.099, 0.128) | 0.113 (0.092, 0.141) | 0.113 (0.095, 0.143) | 0.098 (0.077, 0.119) | 0.097 (0.078, 0.123) | 0.114 (0.097, 0.138) |
| subtype | var | Control | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| —– | graduation | 0 | 26 | 25 | 52 | 63 | 16 |
| —– | futility | 0 | 134 | 106 | 1 | 2 | 102 |
| —– | max_n | 0 | 53 | 31 | 41 | 46 | 44 |
| —– | n | 125 (104, 150) | 45 (18, 103) | 36 (12, 95) | 36 (11, 86) | 38 (10, 94) | 39 (11, 98) |
| —– | n_unique | 116 (95, 140) | 43 (18, 99) | 35 (12, 91) | 34 (10, 83) | 37 (10, 89) | 37 (10, 93) |
| —– | post_p | NA (NA, NA) | 0.45 (0.12, 0.86) | 0.41 (0.1, 0.87) | 0.42 (0.08, 0.88) | 0.44 (0.1, 0.89) | 0.43 (0.09, 0.89) |
| —– | rate | 0.113 (0.1, 0.127) | 0.116 (0.097, 0.156) | 0.117 (0.096, 0.175) | 0.119 (0.093, 0.174) | 0.116 (0.094, 0.176) | 0.117 (0.094, 0.172) |
| —-+ | graduation | 0 | 31 | 29 | 60 | 71 | 17 |
| —-+ | futility | 0 | 146 | 120 | 9 | 11 | 126 |
| —-+ | max_n | 0 | 53 | 31 | 41 | 46 | 44 |
| —-+ | n | 30 (22, 39) | 10 (3, 26) | 10 (3, 25) | 10 (3, 23) | 10 (3, 23) | 13 (5, 28) |
| —-+ | n_unique | 27 (20, 36) | 9 (3, 24) | 9 (2, 23) | 9 (2, 21) | 9 (3, 21) | 12 (4, 26) |
| —-+ | post_p | NA (NA, NA) | 0.47 (0.16, 0.85) | 0.44 (0.16, 0.84) | 0.46 (0.16, 0.84) | 0.46 (0.17, 0.84) | 0.47 (0.19, 0.86) |
| —-+ | rate | 0.114 (0.089, 0.149) | 0.123 (0.081, 0.282) | 0.125 (0.08, 0.268) | 0.122 (0.081, 0.269) | 0.121 (0.08, 0.287) | 0.12 (0.082, 0.218) |
| —+- | graduation | 0 | 27 | 27 | 55 | 69 | 17 |
| —+- | futility | 0 | 141 | 113 | 2 | 3 | 111 |
| —+- | max_n | 0 | 53 | 31 | 41 | 46 | 44 |
| —+- | n | 5 (2, 8) | 3 (0, 6) | 2 (0, 6) | 3 (0, 6) | 2 (0, 5) | 2 (0, 5) |
| —+- | n_unique | 4 (2, 7) | 2 (0, 5) | 2 (0, 5) | 2 (0, 5) | 2 (0, 5) | 2 (0, 5) |
| —+- | post_p | NA (NA, NA) | 0.45 (0.28, 0.72) | 0.47 (0.29, 0.75) | 0.5 (0.28, 0.74) | 0.48 (0.29, 0.74) | 0.46 (0.29, 0.76) |
| —+- | rate | 0.114 (0.057, 0.253) | 0.135 (0.054, 0.455) | 0.134 (0.051, 0.422) | 0.127 (0.041, 0.432) | 0.128 (0.041, 0.521) | 0.14 (0.052, 0.6) |
| —++ | graduation | 0 | 32 | 31 | 63 | 77 | 18 |
| —++ | futility | 0 | 153 | 126 | 10 | 11 | 131 |
| —++ | max_n | 0 | 53 | 31 | 41 | 46 | 44 |
| —++ | n | 13 (8, 19) | 5 (1, 13) | 5 (1, 11) | 5 (1, 11) | 5 (2, 11) | 6 (2, 14) |
| —++ | n_unique | 12 (8, 17) | 5 (1, 12) | 4 (1, 10) | 4 (1, 10) | 4 (1, 10) | 6 (2, 13) |
| —++ | post_p | NA (NA, NA) | 0.44 (0.21, 0.81) | 0.47 (0.23, 0.81) | 0.43 (0.19, 0.8) | 0.46 (0.22, 0.8) | 0.46 (0.2, 0.82) |
| —++ | rate | 0.113 (0.076, 0.172) | 0.13 (0.069, 0.384) | 0.128 (0.068, 0.34) | 0.136 (0.069, 0.436) | 0.13 (0.071, 0.354) | 0.124 (0.074, 0.306) |
| –+– | graduation | 0 | 11 | 3 | 21 | 23 | 6 |
| –+– | futility | 0 | 47 | 44 | 13 | 21 | 42 |
| –+– | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| –+– | n | 26 (19, 33) | 11 (5, 25) | 11 (4, 24) | 9 (3, 22) | 9 (3, 21) | 10 (3, 23) |
| –+– | n_unique | 23 (17, 31) | 10 (4, 22) | 10 (3, 22) | 8 (3, 20) | 8 (3, 20) | 9 (3, 21) |
| –+– | post_p | NA (NA, NA) | 0.42 (0.15, 0.85) | 0.47 (0.16, 0.84) | 0.4 (0.16, 0.82) | 0.44 (0.17, 0.82) | 0.44 (0.16, 0.84) |
| –+– | rate | 0.11 (0.082, 0.152) | 0.123 (0.084, 0.242) | 0.12 (0.078, 0.274) | 0.128 (0.081, 0.259) | 0.125 (0.078, 0.251) | 0.127 (0.079, 0.284) |
| –+-+ | graduation | 0 | 16 | 6 | 29 | 35 | 7 |
| –+-+ | futility | 0 | 71 | 68 | 21 | 25 | 64 |
| –+-+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| –+-+ | n | 25 (18, 32) | 10 (3, 21) | 10 (3, 22) | 9 (3, 21) | 8 (3, 19) | 12 (4, 24) |
| –+-+ | n_unique | 23 (16, 30) | 9 (3, 19) | 9 (3, 19) | 8 (3, 20) | 8 (3, 17) | 11 (4, 22) |
| –+-+ | post_p | NA (NA, NA) | 0.46 (0.18, 0.86) | 0.49 (0.16, 0.86) | 0.42 (0.16, 0.84) | 0.44 (0.17, 0.81) | 0.46 (0.15, 0.85) |
| –+-+ | rate | 0.115 (0.085, 0.15) | 0.122 (0.079, 0.268) | 0.122 (0.078, 0.291) | 0.129 (0.08, 0.258) | 0.127 (0.082, 0.256) | 0.123 (0.083, 0.23) |
| –++- | graduation | 0 | 13 | 5 | 26 | 30 | 7 |
| –++- | futility | 0 | 59 | 58 | 14 | 21 | 49 |
| –++- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| –++- | n | 7 (3, 11) | 3 (1, 7) | 4 (1, 8) | 3 (1, 7) | 3 (1, 7) | 3 (1, 7) |
| –++- | n_unique | 6 (3, 10) | 3 (1, 6) | 4 (1, 8) | 3 (1, 6) | 3 (1, 6) | 3 (1, 6) |
| –++- | post_p | NA (NA, NA) | 0.48 (0.26, 0.78) | 0.44 (0.24, 0.75) | 0.48 (0.29, 0.78) | 0.48 (0.27, 0.76) | 0.46 (0.25, 0.77) |
| –++- | rate | 0.113 (0.064, 0.217) | 0.125 (0.058, 0.463) | 0.129 (0.064, 0.365) | 0.12 (0.052, 0.414) | 0.127 (0.052, 0.459) | 0.136 (0.053, 0.546) |
| –+++ | graduation | 0 | 18 | 8 | 34 | 42 | 8 |
| –+++ | futility | 0 | 79 | 78 | 22 | 25 | 71 |
| –+++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| –+++ | n | 19 (14, 26) | 8 (3, 16) | 8 (3, 18) | 7 (2, 17) | 7 (2, 16) | 9 (4, 19) |
| –+++ | n_unique | 17 (12, 24) | 7 (2, 15) | 7 (3, 16) | 6 (2, 15) | 6 (2, 15) | 9 (4, 17) |
| –+++ | post_p | NA (NA, NA) | 0.46 (0.19, 0.83) | 0.46 (0.19, 0.86) | 0.42 (0.18, 0.81) | 0.44 (0.17, 0.8) | 0.44 (0.18, 0.79) |
| –+++ | rate | 0.111 (0.077, 0.159) | 0.124 (0.075, 0.299) | 0.123 (0.078, 0.28) | 0.13 (0.076, 0.315) | 0.126 (0.076, 0.296) | 0.125 (0.082, 0.244) |
| -+— | graduation | 0 | 26 | 26 | 290 | 308 | 16 |
| -+— | futility | 0 | 154 | 133 | 1 | 2 | 131 |
| -+— | max_n | 0 | 52 | 30 | 38 | 42 | 43 |
| -+— | n | 27 (19, 35) | 5 (1, 16) | 7 (2, 15) | 15 (8, 28) | 14 (7, 27) | 6 (2, 15) |
| -+— | n_unique | 25 (17, 33) | 5 (1, 14) | 6 (2, 14) | 14 (7, 26) | 12 (6, 25) | 6 (2, 13) |
| -+— | post_p | NA (NA, NA) | 0.34 (0.15, 0.66) | 0.33 (0.14, 0.64) | 0.99 (0.86, 1) | 0.98 (0.81, 1) | 0.32 (0.14, 0.64) |
| -+— | rate | 0.112 (0.084, 0.155) | 0.125 (0.076, 0.36) | 0.124 (0.076, 0.261) | 0.036 (0.022, 0.055) | 0.035 (0.021, 0.058) | 0.126 (0.075, 0.3) |
| -+–+ | graduation | 0 | 30 | 30 | 294 | 308 | 17 |
| -+–+ | futility | 0 | 165 | 143 | 9 | 10 | 154 |
| -+–+ | max_n | 0 | 52 | 30 | 38 | 42 | 43 |
| -+–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+–+ | post_p | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.53 (0.5, 0.53) | 0.56 (0.56, 0.56) | 0.49 (0.49, 0.49) |
| -+–+ | rate | 0.169 (0, 1.358) | 0.111 (0, 0.405) | 0.115 (0.017, 0.468) | 0 (0, 0.307) | 0.019 (0, 0.713) | 0.183 (0.029, 9.55) |
| -+-+- | graduation | 0 | 27 | 28 | 290 | 308 | 17 |
| -+-+- | futility | 0 | 161 | 138 | 1 | 3 | 140 |
| -+-+- | max_n | 0 | 52 | 30 | 38 | 42 | 43 |
| -+-+- | n | 12 (8, 18) | 4 (0, 9) | 4 (1, 9) | 7 (3, 13) | 7 (2, 13) | 4 (2, 9) |
| -+-+- | n_unique | 11 (7, 16) | 3 (0, 8) | 4 (1, 8) | 6 (2, 12) | 6 (2, 12) | 4 (1, 8) |
| -+-+- | post_p | NA (NA, NA) | 0.37 (0.19, 0.63) | 0.37 (0.18, 0.63) | 0.88 (0.58, 0.99) | 0.87 (0.58, 0.98) | 0.35 (0.18, 0.65) |
| -+-+- | rate | 0.113 (0.071, 0.173) | 0.126 (0.064, 0.386) | 0.127 (0.066, 0.302) | 0.036 (0.015, 0.075) | 0.035 (0.015, 0.076) | 0.131 (0.062, 0.272) |
| -+-++ | graduation | 0 | 31 | 32 | 294 | 308 | 18 |
| -+-++ | futility | 0 | 172 | 148 | 9 | 10 | 159 |
| -+-++ | max_n | 0 | 52 | 30 | 38 | 42 | 43 |
| -+-++ | n | 5 (2, 8) | 2 (0, 5) | 2 (0, 5) | 2 (0, 6) | 2 (0, 6) | 2 (0, 5) |
| -+-++ | n_unique | 4 (2, 8) | 1 (0, 5) | 2 (0, 5) | 2 (0, 6) | 2 (0, 5) | 2 (0, 5) |
| -+-++ | post_p | NA (NA, NA) | 0.41 (0.25, 0.64) | 0.42 (0.27, 0.6) | 0.67 (0.43, 0.87) | 0.65 (0.43, 0.86) | 0.42 (0.26, 0.61) |
| -+-++ | rate | 0.12 (0.057, 0.251) | 0.135 (0.048, 0.559) | 0.128 (0.057, 0.455) | 0.037 (0, 0.127) | 0.038 (0, 0.122) | 0.125 (0.044, 0.399) |
| -++– | graduation | 0 | 11 | 4 | 290 | 296 | 6 |
| -++– | futility | 0 | 69 | 71 | 11 | 15 | 72 |
| -++– | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| -++– | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -++– | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -++– | post_p | NA (NA, NA) | 0.44 (0.43, 0.47) | 0.48 (0.43, 0.57) | 0.54 (0.48, 0.55) | 0.64 (0.64, 0.64) | NA (NA, NA) |
| -++– | rate | 0.16 (0, 0.602) | 0.172 (0, 1.231) | 0.103 (0, 0.484) | 0.053 (0, 0.131) | 0.052 (0, 0.164) | 0.174 (0.079, 0.634) |
| -++-+ | graduation | 0 | 15 | 7 | 295 | 298 | 7 |
| -++-+ | futility | 0 | 92 | 92 | 19 | 19 | 94 |
| -++-+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| -++-+ | n | 3 (0, 5) | 1 (0, 4) | 2 (0, 4) | 1 (0, 4) | 1 (0, 4) | 1 (0, 3) |
| -++-+ | n_unique | 2 (0, 5) | 1 (0, 3) | 1 (0, 4) | 1 (0, 4) | 1 (0, 4) | 1 (0, 3) |
| -++-+ | post_p | NA (NA, NA) | 0.44 (0.32, 0.62) | 0.44 (0.31, 0.62) | 0.6 (0.42, 0.8) | 0.62 (0.45, 0.82) | 0.45 (0.3, 0.62) |
| -++-+ | rate | 0.121 (0.045, 0.388) | 0.129 (0.023, 0.525) | 0.136 (0.029, 0.506) | 0.044 (0, 0.201) | 0.034 (0, 0.136) | 0.131 (0.036, 0.577) |
| -+++- | graduation | 0 | 13 | 6 | 292 | 297 | 7 |
| -+++- | futility | 0 | 81 | 83 | 11 | 15 | 79 |
| -+++- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| -+++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+++- | post_p | NA (NA, NA) | 0.46 (0.46, 0.46) | 0.47 (0.45, 0.49) | 0.61 (0.61, 0.61) | 0.56 (0.52, 0.57) | 0.54 (0.51, 0.57) |
| -+++- | rate | 0.147 (0, 1.081) | 0.172 (0.056, 3) | 0.099 (0, 0.426) | 0 (0, 0.204) | 0.023 (0, 0.258) | 0.152 (0, 0.385) |
| -++++ | graduation | 0 | 17 | 9 | 297 | 299 | 8 |
| -++++ | futility | 0 | 100 | 101 | 19 | 19 | 101 |
| -++++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| -++++ | n | 3 (1, 5) | 1 (0, 3) | 1 (0, 4) | 2 (0, 4) | 2 (0, 4) | 2 (0, 3) |
| -++++ | n_unique | 2 (0, 5) | 1 (0, 3) | 1 (0, 4) | 1 (0, 4) | 1 (0, 3) | 1 (0, 3) |
| -++++ | post_p | NA (NA, NA) | 0.45 (0.31, 0.62) | 0.45 (0.29, 0.62) | 0.59 (0.44, 0.83) | 0.58 (0.41, 0.78) | 0.45 (0.31, 0.64) |
| -++++ | rate | 0.121 (0.042, 0.329) | 0.129 (0, 0.543) | 0.136 (0, 0.507) | 0.036 (0, 0.159) | 0.04 (0, 0.169) | 0.129 (0.028, 0.522) |
| +—- | graduation | 0 | 6 | 1 | 14 | 15 | 3 |
| +—- | futility | 0 | 7 | 3 | 0 | 0 | 4 |
| +—- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +—- | n | 5 (2, 7) | 3 (1, 5) | 3 (1, 6) | 2 (0, 5) | 2 (0, 5) | 2 (0, 5) |
| +—- | n_unique | 4 (2, 7) | 2 (0, 5) | 3 (1, 5) | 2 (0, 5) | 2 (0, 4) | 2 (0, 5) |
| +—- | post_p | NA (NA, NA) | 0.48 (0.29, 0.73) | 0.46 (0.27, 0.74) | 0.48 (0.3, 0.71) | 0.47 (0.31, 0.76) | 0.45 (0.28, 0.72) |
| +—- | rate | 0.111 (0.05, 0.257) | 0.13 (0.053, 0.402) | 0.126 (0.063, 0.401) | 0.131 (0.04, 0.48) | 0.128 (0.043, 0.443) | 0.141 (0.031, 0.566) |
| +—+ | graduation | 0 | 11 | 6 | 23 | 27 | 5 |
| +—+ | futility | 0 | 35 | 33 | 8 | 9 | 42 |
| +—+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +—+ | n | 2 (0, 4) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) |
| +—+ | n_unique | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 2) | 1 (0, 3) |
| +—+ | post_p | NA (NA, NA) | 0.48 (0.35, 0.66) | 0.47 (0.33, 0.66) | 0.49 (0.34, 0.68) | 0.48 (0.35, 0.67) | 0.5 (0.34, 0.68) |
| +—+ | rate | 0.127 (0.032, 0.496) | 0.131 (0, 0.464) | 0.148 (0.039, 0.579) | 0.118 (0, 0.697) | 0.143 (0, 0.808) | 0.132 (0, 0.463) |
| +–+- | graduation | 0 | 8 | 3 | 20 | 23 | 5 |
| +–+- | futility | 0 | 23 | 21 | 1 | 1 | 18 |
| +–+- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +–+- | n | 7 (4, 12) | 4 (1, 7) | 5 (2, 8) | 3 (1, 7) | 3 (1, 7) | 3 (1, 8) |
| +–+- | n_unique | 6 (3, 11) | 3 (1, 7) | 4 (2, 8) | 3 (1, 7) | 3 (1, 6) | 3 (1, 7) |
| +–+- | post_p | NA (NA, NA) | 0.46 (0.23, 0.76) | 0.47 (0.24, 0.8) | 0.46 (0.24, 0.77) | 0.45 (0.25, 0.8) | 0.48 (0.27, 0.77) |
| +–+- | rate | 0.114 (0.066, 0.2) | 0.13 (0.061, 0.395) | 0.122 (0.063, 0.326) | 0.132 (0.052, 0.367) | 0.142 (0.051, 0.443) | 0.13 (0.06, 0.37) |
| +–++ | graduation | 0 | 13 | 8 | 29 | 35 | 7 |
| +–++ | futility | 0 | 47 | 47 | 9 | 9 | 51 |
| +–++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +–++ | n | 3 (1, 7) | 2 (0, 5) | 2 (0, 4) | 2 (0, 4) | 2 (0, 4) | 2 (1, 5) |
| +–++ | n_unique | 3 (1, 6) | 2 (0, 4) | 2 (0, 4) | 2 (0, 4) | 2 (0, 4) | 2 (0, 5) |
| +–++ | post_p | NA (NA, NA) | 0.49 (0.31, 0.73) | 0.47 (0.29, 0.71) | 0.48 (0.3, 0.72) | 0.46 (0.31, 0.73) | 0.49 (0.3, 0.74) |
| +–++ | rate | 0.122 (0.04, 0.276) | 0.119 (0.032, 0.47) | 0.136 (0.046, 0.528) | 0.129 (0.04, 0.513) | 0.142 (0.04, 0.617) | 0.128 (0.048, 0.429) |
| +-+– | graduation | 0 | 11 | 3 | 21 | 23 | 6 |
| +-+– | futility | 0 | 47 | 44 | 13 | 21 | 42 |
| +-+– | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +-+– | n | 1 (0, 3) | 1 (0, 2) | 1 (0, 3) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) |
| +-+– | n_unique | 1 (0, 3) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) |
| +-+– | post_p | NA (NA, NA) | 0.48 (0.39, 0.67) | 0.49 (0.37, 0.63) | 0.48 (0.38, 0.63) | 0.48 (0.38, 0.65) | 0.48 (0.37, 0.65) |
| +-+– | rate | 0.122 (0, 0.539) | 0.14 (0, 0.622) | 0.13 (0, 0.762) | 0.138 (0, 0.594) | 0.14 (0, 0.541) | 0.133 (0, 0.742) |
| +-+-+ | graduation | 0 | 16 | 6 | 29 | 35 | 7 |
| +-+-+ | futility | 0 | 71 | 68 | 21 | 25 | 64 |
| +-+-+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +-+-+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +-+-+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +-+-+ | post_p | NA (NA, NA) | 0.58 (0.55, 0.59) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.44 (0.44, 0.44) | 0.46 (0.44, 0.47) |
| +-+-+ | rate | 0.089 (0, 1.11) | 0.088 (0, 0.476) | 0.119 (0, 1.14) | 0.09 (0, 0.904) | 0.335 (0, 1.627) | 0.152 (0, 0.362) |
| +-++- | graduation | 0 | 13 | 5 | 26 | 30 | 7 |
| +-++- | futility | 0 | 59 | 58 | 14 | 21 | 49 |
| +-++- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +-++- | n | 21 (15, 28) | 8 (3, 17) | 10 (4, 21) | 8 (3, 19) | 8 (3, 18) | 8 (3, 18) |
| +-++- | n_unique | 19 (13, 26) | 7 (3, 15) | 9 (4, 19) | 7 (3, 17) | 7 (3, 16) | 7 (2, 17) |
| +-++- | post_p | NA (NA, NA) | 0.44 (0.17, 0.84) | 0.48 (0.17, 0.85) | 0.44 (0.18, 0.83) | 0.47 (0.18, 0.83) | 0.44 (0.19, 0.85) |
| +-++- | rate | 0.115 (0.083, 0.155) | 0.129 (0.075, 0.283) | 0.122 (0.082, 0.228) | 0.127 (0.078, 0.263) | 0.12 (0.073, 0.261) | 0.128 (0.074, 0.341) |
| +-+++ | graduation | 0 | 18 | 8 | 34 | 42 | 8 |
| +-+++ | futility | 0 | 79 | 78 | 22 | 25 | 71 |
| +-+++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +-+++ | n | 16 (11, 22) | 6 (2, 14) | 7 (3, 14) | 7 (2, 15) | 7 (2, 14) | 8 (3, 16) |
| +-+++ | n_unique | 14 (9, 20) | 5 (2, 13) | 6 (2, 13) | 6 (2, 13) | 6 (2, 13) | 7 (3, 14) |
| +-+++ | post_p | NA (NA, NA) | 0.47 (0.22, 0.81) | 0.46 (0.18, 0.81) | 0.46 (0.2, 0.82) | 0.48 (0.21, 0.84) | 0.46 (0.2, 0.82) |
| +-+++ | rate | 0.115 (0.08, 0.165) | 0.126 (0.076, 0.3) | 0.127 (0.076, 0.316) | 0.126 (0.075, 0.301) | 0.123 (0.073, 0.264) | 0.128 (0.076, 0.281) |
| ++— | graduation | 0 | 6 | 2 | 289 | 296 | 3 |
| ++— | futility | 0 | 33 | 34 | 0 | 0 | 38 |
| ++— | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++— | n | 8 (5, 13) | 3 (1, 7) | 3 (1, 7) | 4 (2, 10) | 5 (2, 10) | 3 (1, 7) |
| ++— | n_unique | 7 (4, 12) | 3 (1, 6) | 3 (1, 6) | 4 (1, 9) | 4 (1, 9) | 3 (1, 6) |
| ++— | post_p | NA (NA, NA) | 0.39 (0.2, 0.64) | 0.4 (0.21, 0.65) | 0.77 (0.46, 0.96) | 0.78 (0.51, 0.96) | 0.38 (0.22, 0.63) |
| ++— | rate | 0.115 (0.067, 0.194) | 0.132 (0.05, 0.372) | 0.12 (0.056, 0.321) | 0.038 (0.012, 0.102) | 0.037 (0.011, 0.089) | 0.127 (0.054, 0.349) |
| ++–+ | graduation | 0 | 10 | 7 | 294 | 298 | 5 |
| ++–+ | futility | 0 | 60 | 60 | 8 | 8 | 75 |
| ++–+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++–+ | post_p | NA (NA, NA) | 0.5 (0.44, 0.52) | 0.53 (0.47, 0.57) | 0.5 (0.5, 0.5) | NA (NA, NA) | 0.46 (0.46, 0.47) |
| ++–+ | rate | 0.068 (0, 0.675) | 0.27 (0, 0.996) | 0.111 (0, 0.614) | 0 (0, 0.082) | 0.066 (0, 0.343) | 0.181 (0.01, 0.862) |
| ++-+- | graduation | 0 | 8 | 4 | 291 | 297 | 5 |
| ++-+- | futility | 0 | 49 | 50 | 0 | 1 | 52 |
| ++-+- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++-+- | n | 1 (0, 2) | 0 (0, 2) | 1 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) |
| ++-+- | n_unique | 1 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) |
| ++-+- | post_p | NA (NA, NA) | 0.46 (0.4, 0.59) | 0.47 (0.38, 0.58) | 0.57 (0.43, 0.65) | 0.55 (0.44, 0.66) | 0.47 (0.4, 0.6) |
| ++-+- | rate | 0.146 (0, 0.619) | 0.148 (0, 1.051) | 0.144 (0, 0.644) | 0.032 (0, 0.192) | 0.031 (0, 0.23) | 0.146 (0, 0.73) |
| ++-++ | graduation | 0 | 12 | 9 | 296 | 299 | 7 |
| ++-++ | futility | 0 | 72 | 73 | 8 | 8 | 84 |
| ++-++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++-++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++-++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++-++ | post_p | NA (NA, NA) | 0.55 (0.55, 0.55) | 0.5 (0.44, 0.56) | 0.58 (0.58, 0.58) | 0.57 (0.57, 0.57) | 0.46 (0.46, 0.46) |
| ++-++ | rate | 0.153 (0, 0.433) | 0.077 (0, 0.61) | 0.197 (0, 0.608) | 0.029 (0, 0.123) | 0.04 (0, 0.176) | 0.15 (0, 2.599) |
| +++– | graduation | 0 | 11 | 4 | 290 | 296 | 6 |
| +++– | futility | 0 | 69 | 71 | 11 | 15 | 72 |
| +++– | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +++– | n | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) |
| +++– | n_unique | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) |
| +++– | post_p | NA (NA, NA) | 0.48 (0.43, 0.57) | 0.5 (0.41, 0.57) | 0.54 (0.47, 0.59) | 0.53 (0.46, 0.59) | 0.5 (0.41, 0.57) |
| +++– | rate | 0.125 (0, 0.904) | 0.116 (0, 1.111) | 0.11 (0, 0.417) | 0.038 (0, 0.165) | 0.02 (0, 0.215) | 0.147 (0, 0.684) |
| +++-+ | graduation | 0 | 15 | 7 | 295 | 298 | 7 |
| +++-+ | futility | 0 | 92 | 92 | 19 | 19 | 94 |
| +++-+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +++-+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++-+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++-+ | post_p | NA (NA, NA) | 0.53 (0.53, 0.53) | 0.52 (0.52, 0.52) | 0.48 (0.48, 0.48) | 0.56 (0.5, 0.58) | NA (NA, NA) |
| +++-+ | rate | 0.133 (0, 0.634) | 0.128 (0, 0.41) | 0.06 (0, 0.199) | 0.075 (0, 1.073) | 0.055 (0, 0.185) | 0.043 (0, 0.759) |
| ++++- | graduation | 0 | 13 | 6 | 292 | 297 | 7 |
| ++++- | futility | 0 | 81 | 83 | 11 | 15 | 79 |
| ++++- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++- | post_p | NA (NA, NA) | 0.46 (0.46, 0.46) | 0.52 (0.52, 0.52) | 0.55 (0.49, 0.56) | 0.54 (0.52, 0.58) | 0.45 (0.43, 0.5) |
| ++++- | rate | 0.221 (0, 0.594) | 0.147 (0, 4.556) | 0.16 (0, 0.355) | 0.036 (0, 0.133) | 0.04 (0, 0.462) | 0.214 (0, 1.166) |
| +++++ | graduation | 0 | 17 | 9 | 297 | 299 | 8 |
| +++++ | futility | 0 | 100 | 101 | 19 | 19 | 101 |
| +++++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +++++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++++ | post_p | NA (NA, NA) | 0.44 (0.44, 0.44) | 0.51 (0.5, 0.54) | NA (NA, NA) | NA (NA, NA) | 0.52 (0.52, 0.52) |
| +++++ | rate | 0.122 (0, 1.294) | 0.283 (0, 7.532) | 0.105 (0, 1.081) | 0 (0, 0.09) | 0.057 (0, 0.512) | 0.128 (0, 0.355) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|
| all | count | 6 | 1 | 14 | 15 | 3 |
| all | time_stop | 5 (3, 6) | 4 (4, 4) | 7 (6, 9) | 8 (6, 13) | 7 (7, 7) |
| all | n_trt | 33 (26, 38) | 25 (25, 25) | 30 (27, 35) | 30 (25, 50) | 27 (27, 31) |
| all | n_control | 46 (33, 63) | 48 (48, 48) | 68 (53, 86) | 70 (55, 119) | 68 (61, 78) |
| all | post_p | 0.87 (0.86, 0.9) | 0.92 (0.92, 0.92) | 0.97 (0.89, 1) | 0.99 (0.9, 1) | 0.9 (0.87, 0.91) |
| all | order | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) |
| AR- & TP53- | count | 20 | 24 | 39 | 50 | 13 |
| AR- & TP53- | time_stop | 9 (6, 14) | 10 (7, 14) | 14 (9, 25) | 14 (10, 27) | 12 (10, 14) |
| AR- & TP53- | n_trt | 33 (26, 61) | 29 (25, 43) | 40 (26, 92) | 35 (25, 88) | 32 (25, 45) |
| AR- & TP53- | n_control | 46 (32, 79) | 52 (39, 80) | 71 (53, 142) | 79 (54, 165) | 59 (51, 82) |
| AR- & TP53- | post_p | 0.91 (0.88, 0.96) | 0.9 (0.86, 0.94) | 0.99 (0.94, 1) | 0.99 (0.95, 1) | 0.92 (0.88, 0.98) |
| AR- & TP53- | order | 1 (1, 1.2) | 1 (1, 1) | 1 (1, 3) | 1 (1, 2.1) | 1 (1, 2) |
| HRD+ | count | 1 | 275 | 281 | ||
| HRD+ | time_stop | 26 (26, 26) | 23 (17, 33) | 24 (17, 32) | ||
| HRD+ | n_trt | 25 (25, 25) | 27 (25, 45) | 28 (25, 42) | ||
| HRD+ | n_control | 41 (41, 41) | 32 (22, 52) | 36 (22, 52) | ||
| HRD+ | post_p | 0.93 (0.93, 0.93) | 1 (0.98, 1) | 1 (0.98, 1) | ||
| HRD+ | order | 5 (5, 5) | 1 (1, 3) | 2 (1, 3) | ||
| TP53+ | count | 5 | 2 | 7 | 8 | 3 |
| TP53+ | time_stop | 17 (14, 21) | 16 (14, 17) | 19 (13, 23) | 18 (15, 22) | 15 (13, 23) |
| TP53+ | n_trt | 34 (29, 44) | 27 (25, 29) | 30 (28, 35) | 33 (27, 42) | 32 (26, 38) |
| TP53+ | n_control | 49 (35, 64) | 42 (41, 43) | 47 (35, 72) | 51 (36, 72) | 42 (37, 82) |
| TP53+ | post_p | 0.93 (0.87, 0.98) | 0.94 (0.9, 0.97) | 0.98 (0.94, 0.99) | 0.98 (0.95, 0.99) | 0.94 (0.93, 0.96) |
| TP53+ | order | 1 (1, 2) | 1.5 (1.1, 1.9) | 1 (1, 2) | 2 (1, 2) | 2 (1.2, 2) |
| TEfus+ | count | 2 | 2 | 6 | 9 | 2 |
| TEfus+ | time_stop | 12 (10, 14) | 16 (15, 16) | 12 (10, 20) | 18 (13, 19) | 14 (12, 15) |
| TEfus+ | n_trt | 26 (26, 26) | 36 (36, 36) | 26 (25, 36) | 27 (25, 37) | 28 (26, 30) |
| TEfus+ | n_control | 41 (34, 48) | 45 (40, 50) | 32 (24, 60) | 45 (31, 54) | 33 (31, 35) |
| TEfus+ | post_p | 0.92 (0.87, 0.98) | 0.89 (0.89, 0.9) | 0.98 (0.95, 0.99) | 0.98 (0.95, 1) | 0.9 (0.87, 0.93) |
| TEfus+ | order | 1 (1, 1) | 1 (1, 1) | 1 (1, 2.5) | 1 (1, 3) | 1.5 (1.1, 1.9) |
| PI3K+ | count | 5 | 5 | 9 | 12 | 2 |
| PI3K+ | time_stop | 22 (14, 24) | 14 (12, 18) | 15 (14, 19) | 16 (13, 22) | 15 (13, 17) |
| PI3K+ | n_trt | 38 (31, 49) | 26 (25, 27) | 28 (26, 33) | 26 (25, 37) | 36 (32, 40) |
| PI3K+ | n_control | 69 (50, 81) | 41 (35, 47) | 45 (30, 64) | 52 (37, 72) | 46 (40, 51) |
| PI3K+ | post_p | 0.96 (0.9, 0.99) | 0.96 (0.89, 0.99) | 0.96 (0.95, 0.99) | 0.99 (0.91, 0.99) | 0.92 (0.9, 0.94) |
| PI3K+ | order | 1 (1, 3.2) | 2 (1, 2) | 1 (1, 2.2) | 1 (1, 2.9) | 1 (1, 1) |
| signature | var | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|
| all | count | 7 | 3 | 4 | ||
| all | time_stop | 6 (4, 7) | 5 (3, 5) | 10 (10, 11) | ||
| all | n_trt | 32 (27, 42) | 25 (25, 27) | 50 (37, 54) | ||
| all | n_control | 54 (31, 62) | 49 (29, 51) | 92 (77, 106) | ||
| all | post_p | 0.04 (0.01, 0.17) | 0.07 (0.04, 0.14) | 0.01 (0, 0.11) | ||
| all | order | 1 (1, 2) | 1 (1, 1) | 1 (1, 1.7) | ||
| AR- & TP53- | count | 131 | 103 | 1 | 2 | 101 |
| AR- & TP53- | time_stop | 13 (6, 29) | 18 (11, 33) | 11 (11, 11) | 17 (15, 19) | 20 (11, 33) |
| AR- & TP53- | n_trt | 40 (26, 73) | 35 (26, 78) | 26 (26, 26) | 37 (27, 47) | 39 (26, 65) |
| AR- & TP53- | n_control | 68 (36, 166) | 98 (55, 191) | 58 (58, 58) | 94 (80, 108) | 107 (49, 193) |
| AR- & TP53- | post_p | 0.13 (0.03, 0.23) | 0.16 (0.03, 0.27) | 0.27 (0.27, 0.27) | 0.19 (0.15, 0.23) | 0.1 (0.04, 0.24) |
| AR- & TP53- | order | 1 (1, 2) | 1 (1, 3) | 1 (1, 1) | 3 (1.4, 4.6) | 2 (1, 3) |
| HRD+ | count | 26 | 31 | 34 | ||
| HRD+ | time_stop | 32 (28, 35) | 34 (26, 36) | 32 (25, 36) | ||
| HRD+ | n_trt | 27 (25, 40) | 27 (25, 35) | 26 (25, 32) | ||
| HRD+ | n_control | 52 (40, 69) | 51 (39, 65) | 52 (36, 66) | ||
| HRD+ | post_p | 0.15 (0.02, 0.25) | 0.14 (0.07, 0.28) | 0.11 (0.03, 0.24) | ||
| HRD+ | order | 2 (1, 4) | 2 (1, 3) | 2 (1, 3) | ||
| TP53+ | count | 40 | 41 | 13 | 21 | 38 |
| TP53+ | time_stop | 20 (15, 33) | 21 (14, 30) | 21 (17, 33) | 24 (19, 32) | 24 (13, 32) |
| TP53+ | n_trt | 33 (26, 45) | 31 (25, 52) | 27 (25, 36) | 31 (25, 39) | 31 (25, 47) |
| TP53+ | n_control | 62 (37, 118) | 67 (40, 98) | 55 (47, 107) | 76 (58, 102) | 70 (35, 110) |
| TP53+ | post_p | 0.09 (0.02, 0.18) | 0.07 (0.02, 0.22) | 0.11 (0.01, 0.19) | 0.11 (0.01, 0.21) | 0.08 (0.01, 0.22) |
| TP53+ | order | 1.5 (1, 3) | 2 (1, 3) | 2 (1, 3) | 2 (1, 3) | 2 (1, 3) |
| TEfus+ | count | 16 | 18 | 1 | 1 | 15 |
| TEfus+ | time_stop | 22 (19, 32) | 17 (14, 26) | 15 (15, 15) | 25 (25, 25) | 19 (12, 28) |
| TEfus+ | n_trt | 28 (26, 36) | 29 (25, 42) | 25 (25, 25) | 39 (39, 39) | 30 (25, 41) |
| TEfus+ | n_control | 64 (50, 103) | 52 (35, 82) | 30 (30, 30) | 82 (82, 82) | 52 (32, 87) |
| TEfus+ | post_p | 0.06 (0.02, 0.17) | 0.07 (0.01, 0.22) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.06 (0, 0.16) |
| TEfus+ | order | 2 (1, 5) | 3 (1, 3.3) | 1 (1, 1) | 4 (4, 4) | 2 (1, 3) |
| PI3K+ | count | 28 | 30 | 8 | 9 | 40 |
| PI3K+ | time_stop | 24 (16, 32) | 20 (17, 30) | 18 (15, 26) | 26 (22, 32) | 20 (9, 30) |
| PI3K+ | n_trt | 32 (26, 41) | 28 (25, 43) | 28 (26, 35) | 37 (26, 48) | 30 (25, 53) |
| PI3K+ | n_control | 68 (41, 103) | 63 (47, 97) | 55 (45, 79) | 88 (67, 120) | 56 (24, 96) |
| PI3K+ | post_p | 0.07 (0, 0.24) | 0.06 (0.01, 0.22) | 0.1 (0.01, 0.27) | 0.09 (0.04, 0.29) | 0.08 (0.02, 0.19) |
| PI3K+ | order | 2 (1, 3) | 2 (1, 3.1) | 2 (1, 3.3) | 3 (1, 4.2) | 2 (1, 3) |
| signature | treatment | var | —– | —-+ | —+- | —++ | –+– | –+-+ | –++- | –+++ | -+— | -+–+ | -+-+- | -+-++ | -++– | -++-+ | -+++- | -++++ | +—- | +—+ | +–+- | +–++ | +-+– | +-+-+ | +-++- | +-+++ | ++— | ++–+ | ++-+- | ++-++ | +++– | +++-+ | ++++- | +++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | TC1 | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
| all | TC1 | time | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) |
| all | TC1 | n | 18 (14, 21) | 2 (0, 4) | 0 (0, 1) | 0 (0, 2) | 4 (2, 6) | 1 (0, 3) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 1 (0, 2) | 0 (0, 2) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | post_p | 0.63 (0.55, 0.78) | 0.56 (0.55, 0.62) | 0.5 (0.5, 0.5) | 0.52 (0.52, 0.56) | 0.56 (0.51, 0.61) | 0.55 (0.53, 0.57) | NA (NA, NA) | 0.54 (0.53, 0.57) | 0.5 (0.5, 0.5) | NA (NA, NA) | 0.51 (0.5, 0.52) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.56 (0.54, 0.59) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.54 (0.52, 0.54) | 0.59 (0.54, 0.6) | 0.51 (0.5, 0.51) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC1 | r_prob | 0.41 (0.41, 0.41) | 0.22 (0.22, 0.22) | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0.31 (0.31, 0.31) | 0.13 (0.13, 0.13) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | rate | 0.05 (0.035, 0.076) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.26) | 0 (0, 0.108) | 0 (0, 1.867) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0.103) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| all | TC2 | time | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) |
| all | TC2 | n | 9 (9, 9) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 3 (3, 3) | 2 (2, 2) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 1 (1, 1) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 3 (3, 3) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | post_p | 0.86 (0.86, 0.86) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.62 (0.62, 0.62) | 0.53 (0.53, 0.53) | NA (NA, NA) | 0.55 (0.55, 0.55) | NA (NA, NA) | NA (NA, NA) | 0.53 (0.53, 0.53) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.55 (0.55, 0.55) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | r_prob | 0.18 (0.18, 0.18) | 0.03 (0.03, 0.03) | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0.17 (0.17, 0.17) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | rate | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 5.034 (5.034, 5.034) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | count | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 |
| all | TC3 | time | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) | 7 (6, 9) |
| all | TC3 | n | 6 (4, 14) | 1 (0, 2) | 0 (0, 2) | 1 (0, 1) | 2 (0, 4) | 2 (1, 3) | 0 (0, 1) | 1 (0, 3) | 4 (2, 9) | 0 (0, 0) | 2 (1, 5) | 1 (0, 3) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 2) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 2 (0, 3) | 1 (0, 2) | 2 (1, 4) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC3 | post_p | 0.64 (0.54, 0.76) | 0.56 (0.54, 0.66) | 0.67 (0.67, 0.67) | 0.52 (0.51, 0.57) | 0.57 (0.51, 0.65) | 0.58 (0.52, 0.66) | 0.51 (0.51, 0.51) | 0.53 (0.5, 0.55) | 0.58 (0.54, 0.66) | NA (NA, NA) | 0.54 (0.51, 0.6) | 0.55 (0.51, 0.63) | NA (NA, NA) | 0.53 (0.53, 0.53) | NA (NA, NA) | 0.52 (0.52, 0.55) | 0.52 (0.5, 0.53) | NA (NA, NA) | 0.52 (0.51, 0.54) | 0.54 (0.51, 0.58) | NA (NA, NA) | NA (NA, NA) | 0.55 (0.5, 0.6) | 0.55 (0.54, 0.63) | 0.55 (0.53, 0.59) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) |
| all | TC3 | rate | 0.019 (0, 0.12) | 0 (0, 0.024) | 0 (0, 0.073) | 0 (0, 0) | 0 (0, 0.167) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.092) | NA (NA, NA) | 0 (0, 0.13) | 0 (0, 0.019) | 3.523 (3.523, 3.523) | 0 (0, 2.039) | NA (NA, NA) | 0 (0, 0.151) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.602) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0.124) | 0 (0, 0) | 0 (0, 0.07) | NA (NA, NA) | 0.11 (0.022, 0.198) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) |
| all | TC4 | count | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 |
| all | TC4 | time | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) | 8 (6, 13) |
| all | TC4 | n | 9 (4, 15) | 1 (0, 5) | 0 (0, 0) | 1 (0, 2) | 2 (0, 6) | 2 (0, 4) | 0 (0, 1) | 1 (0, 4) | 5 (2, 8) | 0 (0, 0) | 2 (0, 5) | 1 (0, 2) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 2) | 0 (0, 1) | 0 (0, 0) | 0 (0, 2) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 2 (1, 4) | 1 (0, 3) | 1 (0, 4) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC4 | post_p | 0.6 (0.55, 0.79) | 0.63 (0.54, 0.66) | NA (NA, NA) | 0.56 (0.5, 0.7) | 0.56 (0.52, 0.64) | 0.57 (0.53, 0.68) | 0.54 (0.51, 0.59) | 0.55 (0.5, 0.8) | 0.57 (0.52, 0.78) | NA (NA, NA) | 0.59 (0.54, 0.82) | 0.54 (0.52, 0.62) | NA (NA, NA) | 0.57 (0.55, 0.6) | NA (NA, NA) | 0.57 (0.55, 0.62) | 0.56 (0.56, 0.56) | NA (NA, NA) | 0.54 (0.52, 0.56) | 0.54 (0.53, 0.55) | 0.54 (0.54, 0.54) | NA (NA, NA) | 0.55 (0.53, 0.65) | 0.62 (0.53, 0.72) | 0.53 (0.5, 0.56) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) |
| all | TC4 | rate | 0.079 (0, 0.11) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.317) | 0 (0, 0.085) | 0 (0, 0.103) | 0 (0, 0) | 0 (0, 0.123) | 0 (0, 0.031) | NA (NA, NA) | 0 (0, 0.017) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0.012) | NA (NA, NA) | 0 (0, 0.178) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0.037) | 0 (0, 0) | 0 (0, 0.081) | NA (NA, NA) | 0 (0, 0.095) | 0 (0, 0.068) | 0 (0, 0.103) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) |
| all | TC5 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
| all | TC5 | time | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) |
| all | TC5 | n | 5 (5, 6) | 7 (5, 8) | 0 (0, 1) | 1 (0, 2) | 3 (3, 5) | 4 (2, 4) | 0 (0, 0) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 2) | 0 (0, 1) | 1 (0, 2) | 1 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 4 (3, 5) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) |
| all | TC5 | post_p | 0.65 (0.56, 0.68) | 0.67 (0.65, 0.73) | 0.51 (0.51, 0.51) | 0.53 (0.52, 0.54) | 0.54 (0.53, 0.71) | 0.54 (0.52, 0.59) | NA (NA, NA) | NA (NA, NA) | 0.53 (0.51, 0.54) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.53 (0.53, 0.53) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.58 (0.58, 0.58) | 0.53 (0.53, 0.53) | NA (NA, NA) | NA (NA, NA) | 0.51 (0.51, 0.51) | 0.6 (0.54, 0.61) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC5 | rate | 0 (0, 0.082) | 0.048 (0.032, 0.099) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.08) | 0.073 (0.071, 0.116) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0.093 (0.019, 0.152) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) |
| AR- & TP53- | TC1 | count | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | time | 9 (6, 14) | 9 (6, 14) | 9 (6, 14) | 9 (6, 14) | 9 (6, 14) | 9 (6, 14) | 9 (6, 14) | 9 (6, 14) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | n | 23 (18, 39) | 4 (2, 9) | 1 (0, 2) | 2 (0, 4) | 1 (0, 4) | 0 (0, 0) | 1 (0, 2) | 0 (0, 1) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | post_p | 0.82 (0.74, 0.93) | 0.71 (0.53, 0.78) | 0.53 (0.51, 0.55) | 0.6 (0.55, 0.74) | 0.56 (0.51, 0.65) | NA (NA, NA) | 0.53 (0.53, 0.71) | 0.53 (0.53, 0.54) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | r_prob | 0.41 (0.41, 0.41) | 0.22 (0.22, 0.22) | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | rate | 0.073 (0.055, 0.097) | 0.032 (0, 0.083) | 0 (0, 0.22) | 0 (0, 0.068) | 0 (0, 0.041) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0.428) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | count | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | time | 10 (7, 14) | 10 (7, 14) | 10 (7, 14) | 10 (7, 14) | 10 (7, 14) | 10 (7, 14) | 10 (7, 14) | 10 (7, 14) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | n | 21 (16, 31) | 3 (1, 4) | 0 (0, 3) | 2 (0, 4) | 2 (1, 5) | 0 (0, 0) | 0 (0, 2) | 0 (0, 1) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | post_p | 0.81 (0.73, 0.94) | 0.6 (0.52, 0.69) | 0.58 (0.54, 0.63) | 0.55 (0.52, 0.66) | 0.55 (0.51, 0.61) | NA (NA, NA) | 0.54 (0.51, 0.58) | 0.53 (0.5, 0.56) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | r_prob | 0.18 (0.18, 0.18) | 0.03 (0.03, 0.03) | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | rate | 0.067 (0.046, 0.095) | 0 (0, 0.098) | 0 (0, 0.239) | 0 (0, 0.065) | 0 (0, 0.064) | NA (NA, NA) | 0 (0, 0.335) | 0 (0, 0.148) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | count | 39 | 39 | 39 | 39 | 39 | 39 | 39 | 39 | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | time | 14 (9, 25) | 14 (9, 25) | 14 (9, 25) | 14 (9, 25) | 14 (9, 25) | 14 (9, 25) | 14 (9, 25) | 14 (9, 25) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | n | 19 (12, 55) | 4 (0, 11) | 0 (0, 2) | 3 (0, 5) | 8 (4, 15) | 0 (0, 0) | 3 (2, 8) | 1 (0, 3) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | post_p | 0.8 (0.72, 0.93) | 0.62 (0.52, 0.77) | 0.56 (0.5, 0.71) | 0.58 (0.51, 0.75) | 0.8 (0.6, 0.96) | NA (NA, NA) | 0.62 (0.53, 0.85) | 0.59 (0.53, 0.67) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | rate | 0.079 (0.043, 0.094) | 0.072 (0, 0.116) | 0 (0, 0.263) | 0.054 (0, 0.131) | 0.029 (0, 0.056) | NA (NA, NA) | 0.017 (0, 0.065) | 0 (0, 0.103) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | count | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | time | 14 (10, 27) | 14 (10, 27) | 14 (10, 27) | 14 (10, 27) | 14 (10, 27) | 14 (10, 27) | 14 (10, 27) | 14 (10, 27) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | n | 18 (10, 44) | 4 (1, 13) | 0 (0, 2) | 2 (0, 5) | 8 (4, 17) | 0 (0, 0) | 4 (2, 7) | 1 (0, 4) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | post_p | 0.79 (0.7, 0.92) | 0.59 (0.52, 0.79) | 0.56 (0.51, 0.66) | 0.62 (0.53, 0.83) | 0.75 (0.58, 0.96) | NA (NA, NA) | 0.63 (0.52, 0.89) | 0.57 (0.52, 0.77) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | rate | 0.079 (0.036, 0.103) | 0.067 (0, 0.128) | 0 (0, 0.126) | 0.057 (0, 0.106) | 0.028 (0, 0.053) | NA (NA, NA) | 0.016 (0, 0.056) | 0 (0, 0.096) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | count | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | time | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | n | 18 (12, 25) | 8 (4, 11) | 0 (0, 2) | 3 (0, 5) | 2 (0, 4) | 0 (0, 0) | 0 (0, 2) | 0 (0, 1) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | post_p | 0.8 (0.72, 0.86) | 0.76 (0.64, 0.84) | 0.55 (0.53, 0.58) | 0.62 (0.56, 0.72) | 0.54 (0.52, 0.72) | NA (NA, NA) | 0.55 (0.52, 0.59) | 0.55 (0.54, 0.56) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | rate | 0.068 (0.031, 0.093) | 0.043 (0.031, 0.091) | 0.181 (0, 0.689) | 0.066 (0.029, 0.114) | 0 (0, 0.095) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0.337) | ||||||||||||||||||||||||
| HRD+ | TC2 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||
| HRD+ | TC2 | time | 26 (26, 26) | 26 (26, 26) | 26 (26, 26) | 26 (26, 26) | 26 (26, 26) | 26 (26, 26) | 26 (26, 26) | 26 (26, 26) | 26 (26, 26) | 26 (26, 26) | 26 (26, 26) | 26 (26, 26) | 26 (26, 26) | 26 (26, 26) | 26 (26, 26) | 26 (26, 26) | ||||||||||||||||
| HRD+ | TC2 | n | 12 (12, 12) | 0 (0, 0) | 5 (5, 5) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 5 (5, 5) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC2 | post_p | 0.82 (0.82, 0.82) | NA (NA, NA) | 0.5 (0.5, 0.5) | 0.56 (0.56, 0.56) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.63 (0.63, 0.63) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC2 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC2 | rate | 0.044 (0.044, 0.044) | NA (NA, NA) | 0.111 (0.111, 0.111) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.043 (0.043, 0.043) | 0.08 (0.08, 0.08) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC3 | count | 275 | 275 | 275 | 275 | 275 | 275 | 275 | 275 | 275 | 275 | 275 | 275 | 275 | 275 | 275 | 275 | ||||||||||||||||
| HRD+ | TC3 | time | 23 (17, 33) | 23 (17, 33) | 23 (17, 33) | 23 (17, 33) | 23 (17, 33) | 23 (17, 33) | 23 (17, 33) | 23 (17, 33) | 23 (17, 33) | 23 (17, 33) | 23 (17, 33) | 23 (17, 33) | 23 (17, 33) | 23 (17, 33) | 23 (17, 33) | 23 (17, 33) | ||||||||||||||||
| HRD+ | TC3 | n | 13 (8, 21) | 0 (0, 0) | 6 (3, 11) | 2 (0, 5) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 1 (0, 4) | 4 (1, 9) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC3 | post_p | 0.92 (0.74, 1) | 0.57 (0.57, 0.57) | 0.76 (0.55, 0.93) | 0.6 (0.52, 0.78) | 0.53 (0.53, 0.53) | 0.56 (0.52, 0.69) | 0.58 (0.58, 0.58) | 0.58 (0.51, 0.71) | 0.68 (0.53, 0.9) | NA (NA, NA) | 0.56 (0.51, 0.67) | 0.6 (0.6, 0.6) | 0.55 (0.51, 0.59) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC3 | r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| HRD+ | TC3 | rate | 0.032 (0.015, 0.054) | 0 (0, 0.343) | 0.032 (0, 0.068) | 0.021 (0, 0.088) | 0 (0, 0.093) | 0 (0, 0.114) | 0 (0, 0.155) | 0 (0, 0.086) | 0.028 (0, 0.078) | 0 (0, 0.121) | 0 (0, 0.116) | 0.061 (0, 0.123) | 0 (0, 0.15) | 0.082 (0, 1.001) | 0 (0, 0.736) | 0 (0, 0.072) | ||||||||||||||||
| HRD+ | TC4 | count | 281 | 281 | 281 | 281 | 281 | 281 | 281 | 281 | 281 | 281 | 281 | 281 | 281 | 281 | 281 | 281 | ||||||||||||||||
| HRD+ | TC4 | time | 24 (17, 32) | 24 (17, 32) | 24 (17, 32) | 24 (17, 32) | 24 (17, 32) | 24 (17, 32) | 24 (17, 32) | 24 (17, 32) | 24 (17, 32) | 24 (17, 32) | 24 (17, 32) | 24 (17, 32) | 24 (17, 32) | 24 (17, 32) | 24 (17, 32) | 24 (17, 32) | ||||||||||||||||
| HRD+ | TC4 | n | 13 (9, 21) | 0 (0, 0) | 6 (3, 11) | 2 (0, 5) | 0 (0, 0) | 1 (0, 4) | 0 (0, 0) | 1 (0, 3) | 4 (2, 8) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC4 | post_p | 0.92 (0.74, 0.99) | NA (NA, NA) | 0.75 (0.56, 0.95) | 0.6 (0.52, 0.78) | 0.58 (0.58, 0.58) | 0.58 (0.51, 0.73) | 0.55 (0.54, 0.55) | 0.56 (0.51, 0.7) | 0.7 (0.54, 0.89) | NA (NA, NA) | 0.56 (0.51, 0.66) | 0.58 (0.58, 0.58) | 0.54 (0.51, 0.57) | 0.53 (0.52, 0.55) | 0.55 (0.51, 0.58) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC4 | r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| HRD+ | TC4 | rate | 0.033 (0.014, 0.054) | 0.025 (0, 0.849) | 0.031 (0, 0.068) | 0.025 (0, 0.082) | 0 (0, 0.232) | 0.015 (0, 0.087) | 0.045 (0, 0.223) | 0 (0, 0.091) | 0.029 (0, 0.072) | 0 (0, 0.066) | 0 (0, 0.159) | 0 (0, 0.059) | 0 (0, 0.206) | 0 (0, 0.39) | 0.073 (0, 1.178) | 0 (0, 0.21) | ||||||||||||||||
| TP53+ | TC1 | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | ||||||||||||||||
| TP53+ | TC1 | time | 17 (14, 21) | 17 (14, 21) | 17 (14, 21) | 17 (14, 21) | 17 (14, 21) | 17 (14, 21) | 17 (14, 21) | 17 (14, 21) | 17 (14, 21) | 17 (14, 21) | 17 (14, 21) | 17 (14, 21) | 17 (14, 21) | 17 (14, 21) | 17 (14, 21) | 17 (14, 21) | ||||||||||||||||
| TP53+ | TC1 | n | 8 (6, 12) | 7 (2, 14) | 4 (1, 5) | 4 (3, 13) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 0 (0, 2) | 0 (0, 1) | 0 (0, 0) | 4 (3, 7) | 3 (0, 4) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC1 | post_p | 0.77 (0.72, 0.86) | 0.72 (0.56, 0.75) | 0.55 (0.53, 0.56) | 0.74 (0.7, 0.87) | NA (NA, NA) | 0.55 (0.51, 0.65) | NA (NA, NA) | 0.61 (0.61, 0.61) | 0.51 (0.51, 0.51) | NA (NA, NA) | 0.7 (0.6, 0.78) | 0.63 (0.54, 0.7) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC1 | r_prob | 0.31 (0.31, 0.31) | 0.13 (0.13, 0.13) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC1 | rate | 0.07 (0.057, 0.083) | 0.071 (0.023, 0.096) | 0.12 (0.032, 0.184) | 0.08 (0.031, 0.095) | NA (NA, NA) | 0 (0, 0.022) | NA (NA, NA) | 0.077 (0.015, 0.138) | 0 (0, 0) | NA (NA, NA) | 0.102 (0.043, 0.165) | 0.061 (0.037, 0.113) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC2 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||||||||||
| TP53+ | TC2 | time | 16 (14, 17) | 16 (14, 17) | 16 (14, 17) | 16 (14, 17) | 16 (14, 17) | 16 (14, 17) | 16 (14, 17) | 16 (14, 17) | 16 (14, 17) | 16 (14, 17) | 16 (14, 17) | 16 (14, 17) | 16 (14, 17) | 16 (14, 17) | 16 (14, 17) | 16 (14, 17) | ||||||||||||||||
| TP53+ | TC2 | n | 4 (4, 4) | 4 (4, 4) | 4 (3, 4) | 3 (1, 5) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 7 (5, 9) | 4 (2, 5) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | ||||||||||||||||
| TP53+ | TC2 | post_p | 0.72 (0.63, 0.81) | 0.77 (0.63, 0.91) | 0.58 (0.58, 0.59) | 0.56 (0.56, 0.57) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.69 (0.68, 0.71) | 0.55 (0.54, 0.56) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC2 | r_prob | 0.17 (0.17, 0.17) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC2 | rate | 0.047 (0.034, 0.059) | 0.031 (0.026, 0.035) | 0.081 (0.053, 0.108) | 0.059 (0.012, 0.107) | NA (NA, NA) | 0.054 (0.054, 0.054) | NA (NA, NA) | NA (NA, NA) | 0.191 (0.191, 0.191) | NA (NA, NA) | 0.091 (0.069, 0.113) | 0.087 (0.059, 0.115) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC3 | count | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | ||||||||||||||||
| TP53+ | TC3 | time | 19 (13, 23) | 19 (13, 23) | 19 (13, 23) | 19 (13, 23) | 19 (13, 23) | 19 (13, 23) | 19 (13, 23) | 19 (13, 23) | 19 (13, 23) | 19 (13, 23) | 19 (13, 23) | 19 (13, 23) | 19 (13, 23) | 19 (13, 23) | 19 (13, 23) | 19 (13, 23) | ||||||||||||||||
| TP53+ | TC3 | n | 7 (4, 12) | 5 (2, 9) | 1 (0, 3) | 4 (2, 9) | 0 (0, 0) | 1 (1, 2) | 0 (0, 0) | 1 (1, 2) | 0 (0, 0) | 0 (0, 0) | 4 (3, 7) | 5 (2, 5) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC3 | post_p | 0.8 (0.51, 0.87) | 0.71 (0.53, 0.78) | 0.57 (0.51, 0.6) | 0.64 (0.56, 0.88) | NA (NA, NA) | 0.52 (0.51, 0.52) | NA (NA, NA) | 0.56 (0.51, 0.61) | NA (NA, NA) | NA (NA, NA) | 0.69 (0.54, 0.8) | 0.54 (0.52, 0.81) | 0.59 (0.59, 0.59) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC3 | r_prob | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TP53+ | TC3 | rate | 0.059 (0.044, 0.111) | 0.1 (0.032, 0.122) | 0 (0, 0.053) | 0.034 (0, 0.141) | NA (NA, NA) | 0 (0, 0.134) | NA (NA, NA) | 0.015 (0, 0.273) | NA (NA, NA) | NA (NA, NA) | 0.066 (0.028, 0.13) | 0.057 (0.018, 0.129) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC4 | count | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | ||||||||||||||||
| TP53+ | TC4 | time | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | ||||||||||||||||
| TP53+ | TC4 | n | 8 (5, 12) | 7 (3, 12) | 2 (0, 2) | 4 (2, 6) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 2 (0, 3) | 0 (0, 0) | 0 (0, 0) | 5 (4, 8) | 4 (2, 9) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC4 | post_p | 0.78 (0.69, 0.93) | 0.72 (0.63, 0.81) | 0.55 (0.51, 0.59) | 0.57 (0.53, 0.76) | NA (NA, NA) | 0.55 (0.53, 0.56) | NA (NA, NA) | 0.56 (0.54, 0.58) | NA (NA, NA) | NA (NA, NA) | 0.73 (0.58, 0.8) | 0.68 (0.52, 0.82) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC4 | r_prob | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TP53+ | TC4 | rate | 0.059 (0.049, 0.075) | 0.061 (0.034, 0.086) | 0.047 (0, 0.173) | 0.055 (0, 0.098) | NA (NA, NA) | 0 (0, 0.046) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0.061 (0.023, 0.105) | 0.082 (0.013, 0.142) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC5 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||||||||||
| TP53+ | TC5 | time | 15 (13, 23) | 15 (13, 23) | 15 (13, 23) | 15 (13, 23) | 15 (13, 23) | 15 (13, 23) | 15 (13, 23) | 15 (13, 23) | 15 (13, 23) | 15 (13, 23) | 15 (13, 23) | 15 (13, 23) | 15 (13, 23) | 15 (13, 23) | 15 (13, 23) | 15 (13, 23) | ||||||||||||||||
| TP53+ | TC5 | n | 5 (3, 10) | 7 (2, 10) | 2 (1, 3) | 5 (4, 8) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 2) | 0 (0, 0) | 2 (1, 11) | 4 (2, 9) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC5 | post_p | 0.75 (0.66, 0.91) | 0.81 (0.6, 0.85) | 0.53 (0.51, 0.56) | 0.71 (0.57, 0.73) | NA (NA, NA) | 0.5 (0.5, 0.5) | NA (NA, NA) | 0.52 (0.52, 0.52) | NA (NA, NA) | NA (NA, NA) | 0.56 (0.55, 0.71) | 0.62 (0.59, 0.71) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC5 | r_prob | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC5 | rate | 0.033 (0.007, 0.058) | 0.049 (0.01, 0.057) | 0.12 (0.024, 0.138) | 0.041 (0.008, 0.108) | NA (NA, NA) | 0.077 (0.077, 0.077) | NA (NA, NA) | 0 (0, 0) | 0.204 (0.204, 0.204) | NA (NA, NA) | 0 (0, 0.044) | 0.084 (0.017, 0.124) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC1 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||||||||||
| TEfus+ | TC1 | time | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | ||||||||||||||||
| TEfus+ | TC1 | n | 2 (1, 3) | 4 (4, 4) | 1 (0, 2) | 3 (1, 5) | 1 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 2 (1, 2) | 2 (0, 3) | 7 (5, 9) | 4 (4, 5) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC1 | post_p | 0.53 (0.53, 0.54) | 0.59 (0.59, 0.59) | 0.56 (0.56, 0.56) | 0.63 (0.55, 0.71) | 0.56 (0.56, 0.56) | NA (NA, NA) | NA (NA, NA) | 0.52 (0.52, 0.52) | 0.52 (0.52, 0.52) | 0.62 (0.62, 0.62) | 0.74 (0.57, 0.92) | 0.75 (0.75, 0.75) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC1 | r_prob | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC1 | rate | 0.138 (0.084, 0.191) | 0.069 (0.046, 0.092) | 0 (0, 0) | 0.022 (0.004, 0.039) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0.032 (0.006, 0.058) | 0 (0, 0) | 0.077 (0.033, 0.12) | 0.054 (0.011, 0.097) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC2 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||||||||||
| TEfus+ | TC2 | time | 16 (15, 16) | 16 (15, 16) | 16 (15, 16) | 16 (15, 16) | 16 (15, 16) | 16 (15, 16) | 16 (15, 16) | 16 (15, 16) | 16 (15, 16) | 16 (15, 16) | 16 (15, 16) | 16 (15, 16) | 16 (15, 16) | 16 (15, 16) | 16 (15, 16) | 16 (15, 16) | ||||||||||||||||
| TEfus+ | TC2 | n | 0 (0, 1) | 2 (1, 3) | 4 (4, 5) | 4 (3, 4) | 2 (0, 3) | 3 (2, 4) | 0 (0, 0) | 2 (1, 2) | 2 (1, 3) | 1 (1, 1) | 10 (9, 10) | 6 (5, 7) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC2 | post_p | NA (NA, NA) | 0.68 (0.57, 0.79) | 0.53 (0.51, 0.55) | 0.51 (0.51, 0.51) | 0.57 (0.57, 0.57) | 0.58 (0.58, 0.58) | NA (NA, NA) | NA (NA, NA) | 0.57 (0.56, 0.57) | 0.55 (0.55, 0.55) | 0.76 (0.75, 0.76) | 0.66 (0.6, 0.72) | 0.5 (0.5, 0.5) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC2 | r_prob | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC2 | rate | 0.283 (0.283, 0.283) | 0.024 (0.005, 0.043) | 0.117 (0.107, 0.127) | 0.135 (0.131, 0.14) | 0 (0, 0) | 0.115 (0.023, 0.207) | NA (NA, NA) | 0.104 (0.021, 0.187) | 0.037 (0.007, 0.067) | 0 (0, 0) | 0.08 (0.049, 0.111) | 0.089 (0.084, 0.095) | 0.113 (0.023, 0.203) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC3 | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | ||||||||||||||||
| TEfus+ | TC3 | time | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | ||||||||||||||||
| TEfus+ | TC3 | n | 1 (0, 2) | 4 (1, 4) | 2 (0, 2) | 2 (1, 4) | 4 (2, 8) | 2 (1, 2) | 0 (0, 0) | 1 (0, 2) | 1 (0, 4) | 1 (0, 2) | 4 (2, 4) | 6 (4, 9) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC3 | post_p | 0.54 (0.54, 0.54) | 0.63 (0.57, 0.68) | 0.55 (0.51, 0.67) | 0.6 (0.54, 0.65) | 0.65 (0.59, 0.79) | 0.55 (0.54, 0.56) | NA (NA, NA) | 0.57 (0.53, 0.6) | 0.57 (0.52, 0.71) | 0.52 (0.52, 0.53) | 0.6 (0.53, 0.66) | 0.64 (0.52, 0.81) | 0.58 (0.58, 0.58) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TEfus+ | TC3 | rate | 0.037 (0, 0.521) | 0.076 (0.025, 0.085) | 0 (0, 0.056) | 0 (0, 0.028) | 0 (0, 0.037) | 0 (0, 0.082) | NA (NA, NA) | 0.015 (0, 0.102) | 0.048 (0, 0.209) | 0 (0, 4.559) | 0.058 (0.022, 0.113) | 0.084 (0.021, 0.14) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC4 | count | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | ||||||||||||||||
| TEfus+ | TC4 | time | 18 (13, 19) | 18 (13, 19) | 18 (13, 19) | 18 (13, 19) | 18 (13, 19) | 18 (13, 19) | 18 (13, 19) | 18 (13, 19) | 18 (13, 19) | 18 (13, 19) | 18 (13, 19) | 18 (13, 19) | 18 (13, 19) | 18 (13, 19) | 18 (13, 19) | 18 (13, 19) | ||||||||||||||||
| TEfus+ | TC4 | n | 1 (0, 2) | 3 (2, 6) | 1 (1, 4) | 3 (1, 9) | 3 (2, 4) | 2 (1, 3) | 0 (0, 0) | 2 (0, 4) | 2 (1, 2) | 1 (0, 1) | 5 (3, 10) | 5 (3, 8) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC4 | post_p | 0.64 (0.56, 0.74) | 0.61 (0.52, 0.88) | 0.58 (0.54, 0.66) | 0.62 (0.53, 0.88) | 0.64 (0.58, 0.85) | 0.54 (0.52, 0.62) | NA (NA, NA) | 0.59 (0.52, 0.63) | 0.62 (0.57, 0.68) | 0.56 (0.56, 0.56) | 0.6 (0.53, 0.94) | 0.56 (0.51, 0.75) | 0.54 (0.53, 0.55) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TEfus+ | TC4 | rate | 0 (0, 0) | 0.062 (0, 0.16) | 0 (0, 0.049) | 0.035 (0, 0.068) | 0.012 (0, 0.043) | 0.016 (0, 0.069) | NA (NA, NA) | 0.021 (0, 0.052) | 0 (0, 0.099) | 0.275 (0, 0.572) | 0.067 (0, 0.104) | 0.059 (0.029, 0.116) | 0.114 (0, 0.492) | 0.09 (0.09, 0.09) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC5 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||||||||||
| TEfus+ | TC5 | time | 14 (12, 15) | 14 (12, 15) | 14 (12, 15) | 14 (12, 15) | 14 (12, 15) | 14 (12, 15) | 14 (12, 15) | 14 (12, 15) | 14 (12, 15) | 14 (12, 15) | 14 (12, 15) | 14 (12, 15) | 14 (12, 15) | 14 (12, 15) | 14 (12, 15) | 14 (12, 15) | ||||||||||||||||
| TEfus+ | TC5 | n | 1 (1, 1) | 2 (2, 3) | 2 (1, 2) | 10 (9, 10) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 0 (0, 1) | 1 (0, 2) | 0 (0, 1) | 1 (1, 1) | 10 (9, 10) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC5 | post_p | 0.57 (0.57, 0.57) | 0.57 (0.52, 0.62) | 0.54 (0.53, 0.56) | 0.72 (0.7, 0.74) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.52 (0.52, 0.52) | 0.57 (0.57, 0.57) | 0.54 (0.54, 0.54) | 0.52 (0.51, 0.54) | 0.82 (0.75, 0.89) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC5 | rate | 0 (0, 0) | 0.126 (0.025, 0.227) | 0 (0, 0) | 0.032 (0.006, 0.058) | NA (NA, NA) | 0.21 (0.184, 0.235) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.074 (0.015, 0.133) | 0.065 (0.05, 0.08) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC1 | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | ||||||||||||||||
| PI3K+ | TC1 | time | 22 (14, 24) | 22 (14, 24) | 22 (14, 24) | 22 (14, 24) | 22 (14, 24) | 22 (14, 24) | 22 (14, 24) | 22 (14, 24) | 22 (14, 24) | 22 (14, 24) | 22 (14, 24) | 22 (14, 24) | 22 (14, 24) | 22 (14, 24) | 22 (14, 24) | 22 (14, 24) | ||||||||||||||||
| PI3K+ | TC1 | n | 7 (5, 13) | 3 (0, 7) | 14 (3, 21) | 10 (4, 11) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 2) | 2 (0, 3) | 0 (0, 0) | 4 (3, 6) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC1 | post_p | 0.76 (0.67, 0.83) | 0.7 (0.6, 0.78) | 0.75 (0.63, 0.84) | 0.71 (0.59, 0.9) | NA (NA, NA) | NA (NA, NA) | 0.57 (0.54, 0.59) | 0.55 (0.55, 0.55) | NA (NA, NA) | 0.62 (0.58, 0.66) | NA (NA, NA) | 0.7 (0.56, 0.71) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC1 | r_prob | 0.22 (0.22, 0.22) | 0.22 (0.22, 0.22) | 0.13 (0.13, 0.13) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.14 (0.14, 0.14) | 0.14 (0.14, 0.14) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC1 | rate | 0.092 (0.052, 0.105) | 0.063 (0.061, 0.084) | 0.072 (0.055, 0.103) | 0.097 (0.061, 0.129) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0.15 (0.099, 0.201) | 0.114 (0.109, 0.119) | 0.065 (0.033, 0.757) | NA (NA, NA) | 0.085 (0.081, 0.114) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC2 | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | ||||||||||||||||
| PI3K+ | TC2 | time | 14 (12, 18) | 14 (12, 18) | 14 (12, 18) | 14 (12, 18) | 14 (12, 18) | 14 (12, 18) | 14 (12, 18) | 14 (12, 18) | 14 (12, 18) | 14 (12, 18) | 14 (12, 18) | 14 (12, 18) | 14 (12, 18) | 14 (12, 18) | 14 (12, 18) | 14 (12, 18) | ||||||||||||||||
| PI3K+ | TC2 | n | 5 (1, 7) | 2 (0, 3) | 4 (4, 7) | 5 (3, 6) | 0 (0, 1) | 1 (0, 3) | 0 (0, 2) | 0 (0, 0) | 0 (0, 2) | 3 (1, 4) | 0 (0, 0) | 4 (2, 7) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | ||||||||||||||||
| PI3K+ | TC2 | post_p | 0.72 (0.61, 0.76) | 0.58 (0.56, 0.6) | 0.66 (0.54, 0.86) | 0.6 (0.56, 0.75) | NA (NA, NA) | 0.54 (0.52, 0.55) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.54 (0.53, 0.56) | NA (NA, NA) | 0.57 (0.54, 0.75) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC2 | r_prob | 0.03 (0.03, 0.03) | 0.03 (0.03, 0.03) | 0.07 (0.07, 0.07) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.21 (0.21, 0.21) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC2 | rate | 0.046 (0.01, 0.084) | 0.066 (0.055, 0.071) | 0.047 (0.037, 0.097) | 0.061 (0.019, 0.153) | 0 (0, 0) | 0 (0, 0.118) | 0.336 (0.067, 0.606) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0.052) | NA (NA, NA) | 0.076 (0.044, 0.111) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC3 | count | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | ||||||||||||||||
| PI3K+ | TC3 | time | 15 (14, 19) | 15 (14, 19) | 15 (14, 19) | 15 (14, 19) | 15 (14, 19) | 15 (14, 19) | 15 (14, 19) | 15 (14, 19) | 15 (14, 19) | 15 (14, 19) | 15 (14, 19) | 15 (14, 19) | 15 (14, 19) | 15 (14, 19) | 15 (14, 19) | 15 (14, 19) | ||||||||||||||||
| PI3K+ | TC3 | n | 8 (3, 10) | 1 (0, 3) | 5 (2, 9) | 4 (2, 9) | 0 (0, 0) | 3 (0, 5) | 0 (0, 2) | 2 (1, 2) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 4 (2, 8) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC3 | post_p | 0.75 (0.62, 0.84) | 0.56 (0.51, 0.77) | 0.69 (0.55, 0.76) | 0.71 (0.59, 0.82) | NA (NA, NA) | 0.62 (0.53, 0.76) | 0.63 (0.54, 0.64) | 0.55 (0.51, 0.57) | 0.58 (0.58, 0.58) | 0.56 (0.56, 0.56) | NA (NA, NA) | 0.67 (0.55, 0.85) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| PI3K+ | TC3 | rate | 0.065 (0.052, 0.076) | 0 (0, 0.142) | 0.071 (0.036, 0.124) | 0.052 (0.016, 0.071) | NA (NA, NA) | 0.029 (0, 0.047) | 0 (0, 0.062) | 0 (0, 0.059) | 0.092 (0.092, 0.092) | 0.101 (0, 0.238) | NA (NA, NA) | 0.061 (0, 0.078) | 0.212 (0.212, 0.212) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC4 | count | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | ||||||||||||||||
| PI3K+ | TC4 | time | 16 (13, 22) | 16 (13, 22) | 16 (13, 22) | 16 (13, 22) | 16 (13, 22) | 16 (13, 22) | 16 (13, 22) | 16 (13, 22) | 16 (13, 22) | 16 (13, 22) | 16 (13, 22) | 16 (13, 22) | 16 (13, 22) | 16 (13, 22) | 16 (13, 22) | 16 (13, 22) | ||||||||||||||||
| PI3K+ | TC4 | n | 6 (3, 14) | 2 (0, 4) | 6 (3, 9) | 3 (2, 6) | 0 (0, 0) | 1 (0, 3) | 0 (0, 1) | 2 (0, 3) | 0 (0, 2) | 2 (0, 3) | 0 (0, 0) | 3 (1, 5) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC4 | post_p | 0.72 (0.53, 0.86) | 0.62 (0.51, 0.82) | 0.78 (0.7, 0.89) | 0.71 (0.51, 0.78) | NA (NA, NA) | 0.56 (0.51, 0.68) | 0.56 (0.54, 0.6) | 0.59 (0.54, 0.69) | 0.57 (0.57, 0.57) | 0.6 (0.56, 0.61) | NA (NA, NA) | 0.56 (0.5, 0.73) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| PI3K+ | TC4 | rate | 0.069 (0.019, 0.11) | 0.067 (0, 0.09) | 0.053 (0.031, 0.068) | 0.071 (0, 0.16) | NA (NA, NA) | 0 (0, 0.079) | 0 (0, 0) | 0 (0, 0.078) | 0.155 (0, 6.301) | 0.056 (0, 0.233) | NA (NA, NA) | 0.073 (0, 0.124) | NA (NA, NA) | NA (NA, NA) | 0.124 (0.124, 0.124) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC5 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||||||||||
| PI3K+ | TC5 | time | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | 15 (13, 17) | ||||||||||||||||
| PI3K+ | TC5 | n | 12 (9, 16) | 6 (4, 8) | 6 (4, 7) | 5 (5, 5) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 1 (1, 1) | 0 (0, 1) | 0 (0, 0) | 4 (4, 4) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC5 | post_p | 0.77 (0.74, 0.8) | 0.7 (0.65, 0.75) | 0.64 (0.58, 0.7) | 0.66 (0.59, 0.72) | NA (NA, NA) | 0.6 (0.6, 0.6) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.66 (0.65, 0.68) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC5 | r_prob | 0.38 (0.38, 0.38) | 0.38 (0.38, 0.38) | 0.33 (0.33, 0.33) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC5 | rate | 0.072 (0.044, 0.1) | 0.087 (0.06, 0.114) | 0.074 (0.055, 0.094) | 0.113 (0.063, 0.163) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0.155 (0.113, 0.198) | 0.169 (0.169, 0.169) | NA (NA, NA) | 0.088 (0.082, 0.093) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| signature | treatment | var | —– | —-+ | —+- | —++ | –+– | –+-+ | –++- | –+++ | -+— | -+–+ | -+-+- | -+-++ | -++– | -++-+ | -+++- | -++++ | +—- | +—+ | +–+- | +–++ | +-+– | +-+-+ | +-++- | +-+++ | ++— | ++–+ | ++-+- | ++-++ | +++– | +++-+ | ++++- | +++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | TC1 | count | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 |
| all | TC1 | time | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) |
| all | TC1 | n | 17 (12, 22) | 3 (2, 5) | 2 (1, 2) | 1 (1, 3) | 3 (2, 6) | 1 (1, 4) | 0 (0, 1) | 1 (0, 3) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 2) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | post_p | 0.33 (0.17, 0.41) | 0.45 (0.45, 0.47) | 0.45 (0.44, 0.48) | 0.43 (0.36, 0.44) | 0.4 (0.32, 0.49) | 0.39 (0.37, 0.47) | 0.46 (0.44, 0.49) | 0.48 (0.47, 0.48) | 0.48 (0.48, 0.48) | NA (NA, NA) | 0.42 (0.42, 0.42) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.48 (0.47, 0.49) | 0.42 (0.42, 0.42) | NA (NA, NA) | 0.46 (0.46, 0.46) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.39 (0.36, 0.42) | 0.46 (0.42, 0.49) | 0.49 (0.49, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC1 | r_prob | 0.41 (0.41, 0.41) | 0.22 (0.22, 0.22) | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0.31 (0.31, 0.31) | 0.13 (0.13, 0.13) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | rate | 0.153 (0.103, 0.209) | 0.147 (0.055, 0.205) | 0.203 (0, 1.074) | 0.286 (0, 0.972) | 0.348 (0.176, 0.48) | 0.224 (0.052, 1.218) | 0.856 (0.171, 1.541) | 0.152 (0.031, 0.224) | 0 (0, 0) | NA (NA, NA) | 0.541 (0.417, 0.664) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0.292 (0.058, 0.408) | NA (NA, NA) | 1.692 (0.338, 3.046) | 0.364 (0.364, 0.364) | 0 (0, 0) | NA (NA, NA) | 3.072 (1.696, 4.449) | 0.13 (0.026, 0.234) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
| all | TC2 | time | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) | 5 (3, 5) |
| all | TC2 | n | 7 (6, 9) | 1 (0, 2) | 0 (0, 1) | 0 (0, 0) | 3 (1, 3) | 1 (0, 3) | 1 (0, 2) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 2 (1, 2) | 0 (0, 0) | 2 (1, 2) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 5 (4, 7) | 1 (0, 3) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | post_p | 0.41 (0.33, 0.47) | 0.45 (0.41, 0.49) | NA (NA, NA) | NA (NA, NA) | 0.47 (0.45, 0.48) | 0.38 (0.38, 0.38) | 0.44 (0.44, 0.44) | 0.38 (0.38, 0.38) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.4 (0.38, 0.42) | NA (NA, NA) | 0.49 (0.49, 0.5) | 0.42 (0.42, 0.42) | NA (NA, NA) | NA (NA, NA) | 0.43 (0.39, 0.46) | 0.47 (0.46, 0.48) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | r_prob | 0.18 (0.18, 0.18) | 0.03 (0.03, 0.03) | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0.17 (0.17, 0.17) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | rate | 0.223 (0.101, 0.325) | 0.134 (0.027, 0.241) | 0 (0, 0) | NA (NA, NA) | 0.382 (0.076, 0.688) | 0.139 (0.028, 0.25) | 0.354 (0.336, 0.372) | 0.833 (0.833, 0.833) | 2.831 (2.831, 2.831) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.231 (0.046, 0.985) | NA (NA, NA) | 0 (0, 0.146) | 0.454 (0.454, 0.454) | NA (NA, NA) | NA (NA, NA) | 0.307 (0.113, 0.328) | 0.101 (0.02, 0.181) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC5 | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| all | TC5 | time | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) | 10 (10, 11) |
| all | TC5 | n | 12 (6, 15) | 6 (5, 11) | 3 (2, 4) | 4 (2, 6) | 2 (1, 4) | 4 (3, 4) | 0 (0, 1) | 6 (3, 6) | 2 (2, 4) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 2 (0, 3) | 2 (1, 4) | 0 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC5 | post_p | 0.26 (0.15, 0.36) | 0.35 (0.33, 0.45) | 0.45 (0.43, 0.46) | 0.35 (0.23, 0.42) | 0.37 (0.35, 0.42) | 0.37 (0.28, 0.43) | 0.44 (0.44, 0.44) | 0.33 (0.18, 0.44) | 0.4 (0.28, 0.45) | NA (NA, NA) | 0.47 (0.45, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.46 (0.46, 0.46) | 0.48 (0.48, 0.48) | NA (NA, NA) | 0.43 (0.43, 0.43) | NA (NA, NA) | NA (NA, NA) | 0.48 (0.38, 0.49) | 0.43 (0.4, 0.47) | 0.36 (0.36, 0.36) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC5 | rate | 0.159 (0.143, 0.185) | 0.21 (0.155, 0.258) | 0.215 (0.054, 0.293) | 0.155 (0.143, 0.6) | 1.283 (0.273, 2.301) | 0.249 (0.11, 0.865) | 2.555 (2.555, 2.555) | 0.245 (0.148, 0.269) | 0.172 (0.131, 0.214) | NA (NA, NA) | 0.187 (0.113, 0.26) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.133 (0.133, 0.133) | 0 (0, 0) | NA (NA, NA) | 0.975 (0.862, 1.089) | NA (NA, NA) | NA (NA, NA) | 0.136 (0.122, 0.878) | 0.203 (0.1, 0.471) | 0.17 (0.17, 0.17) | NA (NA, NA) | 0.28 (0.056, 0.505) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| AR- & TP53- | TC1 | count | 131 | 131 | 131 | 131 | 131 | 131 | 131 | 131 | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | time | 13 (6, 29) | 13 (6, 29) | 13 (6, 29) | 13 (6, 29) | 13 (6, 29) | 13 (6, 29) | 13 (6, 29) | 13 (6, 29) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | n | 24 (16, 47) | 5 (2, 13) | 1 (0, 3) | 2 (0, 6) | 3 (0, 7) | 0 (0, 0) | 2 (0, 5) | 0 (0, 3) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | post_p | 0.32 (0.12, 0.46) | 0.39 (0.2, 0.49) | 0.43 (0.28, 0.49) | 0.4 (0.28, 0.48) | 0.39 (0.24, 0.47) | NA (NA, NA) | 0.41 (0.27, 0.48) | 0.4 (0.29, 0.48) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | r_prob | 0.41 (0.41, 0.41) | 0.22 (0.22, 0.22) | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | rate | 0.126 (0.101, 0.163) | 0.155 (0.102, 0.51) | 0.181 (0, 0.681) | 0.195 (0.096, 0.601) | 0.147 (0.074, 0.777) | 0 (0, 0) | 0.169 (0.08, 0.6) | 0.202 (0.02, 1.006) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | count | 103 | 103 | 103 | 103 | 103 | 103 | 103 | 103 | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | time | 18 (11, 33) | 18 (11, 33) | 18 (11, 33) | 18 (11, 33) | 18 (11, 33) | 18 (11, 33) | 18 (11, 33) | 18 (11, 33) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | n | 21 (9, 47) | 4 (2, 12) | 1 (0, 3) | 2 (0, 6) | 5 (2, 9) | 0 (0, 0) | 2 (0, 6) | 1 (0, 3) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | post_p | 0.33 (0.1, 0.47) | 0.36 (0.18, 0.47) | 0.42 (0.32, 0.48) | 0.4 (0.24, 0.48) | 0.38 (0.21, 0.46) | NA (NA, NA) | 0.41 (0.27, 0.49) | 0.42 (0.34, 0.48) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | r_prob | 0.18 (0.18, 0.18) | 0.03 (0.03, 0.03) | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | rate | 0.131 (0.106, 0.201) | 0.168 (0.116, 0.482) | 0.178 (0.063, 0.781) | 0.18 (0.11, 0.54) | 0.13 (0.076, 0.27) | NA (NA, NA) | 0.134 (0.072, 0.613) | 0.181 (0.067, 1.45) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | time | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | n | 13 (13, 13) | 3 (3, 3) | 1 (1, 1) | 1 (1, 1) | 6 (6, 6) | 0 (0, 0) | 2 (2, 2) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | post_p | 0.33 (0.33, 0.33) | 0.47 (0.47, 0.47) | 0.42 (0.42, 0.42) | 0.44 (0.44, 0.44) | 0.48 (0.48, 0.48) | NA (NA, NA) | 0.39 (0.39, 0.39) | NA (NA, NA) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | rate | 0.167 (0.167, 0.167) | 0.096 (0.096, 0.096) | 0.241 (0.241, 0.241) | 0.28 (0.28, 0.28) | 0.05 (0.05, 0.05) | NA (NA, NA) | 0.104 (0.104, 0.104) | NA (NA, NA) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | time | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | n | 14 (13, 15) | 5 (3, 7) | 2 (0, 4) | 2 (2, 3) | 8 (5, 11) | 0 (0, 0) | 4 (1, 8) | 1 (0, 2) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | post_p | 0.25 (0.09, 0.41) | 0.23 (0.16, 0.3) | 0.42 (0.42, 0.42) | 0.34 (0.32, 0.36) | 0.39 (0.35, 0.43) | NA (NA, NA) | 0.46 (0.46, 0.46) | 0.44 (0.44, 0.44) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | rate | 0.139 (0.119, 0.158) | 0.286 (0.2, 0.371) | 0.084 (0.084, 0.084) | 0.285 (0.157, 0.413) | 0.124 (0.115, 0.133) | NA (NA, NA) | 0.036 (0.036, 0.036) | 0.048 (0.048, 0.048) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | count | 101 | 101 | 101 | 101 | 101 | 101 | 101 | 101 | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | time | 20 (11, 33) | 20 (11, 33) | 20 (11, 33) | 20 (11, 33) | 20 (11, 33) | 20 (11, 33) | 20 (11, 33) | 20 (11, 33) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | n | 15 (8, 32) | 7 (4, 14) | 1 (0, 3) | 4 (2, 9) | 4 (1, 8) | 0 (0, 0) | 3 (0, 6) | 1 (0, 3) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | post_p | 0.3 (0.1, 0.47) | 0.36 (0.18, 0.49) | 0.43 (0.35, 0.49) | 0.37 (0.19, 0.47) | 0.36 (0.16, 0.47) | NA (NA, NA) | 0.39 (0.19, 0.48) | 0.43 (0.33, 0.48) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | rate | 0.138 (0.113, 0.213) | 0.15 (0.106, 0.266) | 0.184 (0.068, 0.6) | 0.162 (0.096, 0.394) | 0.153 (0.093, 0.493) | NA (NA, NA) | 0.151 (0.08, 0.399) | 0.147 (0.039, 0.542) | ||||||||||||||||||||||||
| HRD+ | TC1 | count | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | ||||||||||||||||
| HRD+ | TC1 | time | 32 (28, 35) | 32 (28, 35) | 32 (28, 35) | 32 (28, 35) | 32 (28, 35) | 32 (28, 35) | 32 (28, 35) | 32 (28, 35) | 32 (28, 35) | 32 (28, 35) | 32 (28, 35) | 32 (28, 35) | 32 (28, 35) | 32 (28, 35) | 32 (28, 35) | 32 (28, 35) | ||||||||||||||||
| HRD+ | TC1 | n | 10 (6, 17) | 0 (0, 0) | 7 (2, 14) | 2 (1, 6) | 0 (0, 0) | 2 (0, 3) | 0 (0, 0) | 1 (0, 3) | 3 (2, 6) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC1 | post_p | 0.28 (0.16, 0.45) | NA (NA, NA) | 0.37 (0.17, 0.46) | 0.4 (0.33, 0.45) | NA (NA, NA) | 0.43 (0.37, 0.47) | NA (NA, NA) | 0.4 (0.34, 0.49) | 0.29 (0.19, 0.48) | NA (NA, NA) | 0.45 (0.38, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC1 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC1 | rate | 0.123 (0.087, 0.15) | NA (NA, NA) | 0.123 (0.087, 0.289) | 0.137 (0.088, 0.414) | 0.168 (0.168, 0.168) | 0.19 (0.086, 0.71) | 0.136 (0.136, 0.136) | 0.193 (0.074, 0.713) | 0.18 (0.092, 0.26) | 0.436 (0.436, 0.436) | 0.259 (0.104, 0.955) | 0.319 (0.064, 0.574) | 0.452 (0, 1.745) | 0.108 (0.083, 0.134) | 0.241 (0.241, 0.241) | 0.333 (0.333, 0.333) | ||||||||||||||||
| HRD+ | TC2 | count | 31 | 31 | 31 | 31 | 31 | 31 | 31 | 31 | 31 | 31 | 31 | 31 | 31 | 31 | 31 | 31 | ||||||||||||||||
| HRD+ | TC2 | time | 34 (26, 36) | 34 (26, 36) | 34 (26, 36) | 34 (26, 36) | 34 (26, 36) | 34 (26, 36) | 34 (26, 36) | 34 (26, 36) | 34 (26, 36) | 34 (26, 36) | 34 (26, 36) | 34 (26, 36) | 34 (26, 36) | 34 (26, 36) | 34 (26, 36) | 34 (26, 36) | ||||||||||||||||
| HRD+ | TC2 | n | 11 (6, 13) | 0 (0, 0) | 6 (2, 8) | 3 (1, 5) | 0 (0, 0) | 2 (0, 4) | 0 (0, 0) | 1 (0, 3) | 4 (2, 7) | 0 (0, 0) | 0 (0, 2) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC2 | post_p | 0.28 (0.14, 0.47) | NA (NA, NA) | 0.34 (0.2, 0.47) | 0.38 (0.29, 0.46) | NA (NA, NA) | 0.42 (0.38, 0.48) | 0.46 (0.44, 0.49) | 0.43 (0.3, 0.48) | 0.33 (0.21, 0.45) | NA (NA, NA) | 0.45 (0.42, 0.48) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC2 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC2 | rate | 0.117 (0.092, 0.174) | 0.3 (0.214, 0.387) | 0.127 (0.08, 0.213) | 0.135 (0.077, 0.324) | 0.92 (0.92, 0.92) | 0.132 (0.072, 0.318) | 0.346 (0.185, 0.745) | 0.224 (0.099, 1.191) | 0.138 (0.093, 0.474) | NA (NA, NA) | 0.2 (0.076, 0.381) | 0.279 (0.043, 0.591) | 0 (0, 0.209) | 0.089 (0.089, 0.089) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC5 | count | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | ||||||||||||||||
| HRD+ | TC5 | time | 32 (25, 36) | 32 (25, 36) | 32 (25, 36) | 32 (25, 36) | 32 (25, 36) | 32 (25, 36) | 32 (25, 36) | 32 (25, 36) | 32 (25, 36) | 32 (25, 36) | 32 (25, 36) | 32 (25, 36) | 32 (25, 36) | 32 (25, 36) | 32 (25, 36) | 32 (25, 36) | ||||||||||||||||
| HRD+ | TC5 | n | 10 (5, 15) | 0 (0, 0) | 6 (3, 9) | 3 (0, 6) | 0 (0, 0) | 2 (0, 3) | 0 (0, 0) | 1 (0, 4) | 3 (1, 6) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC5 | post_p | 0.27 (0.11, 0.42) | NA (NA, NA) | 0.33 (0.2, 0.47) | 0.4 (0.28, 0.47) | NA (NA, NA) | 0.42 (0.29, 0.48) | NA (NA, NA) | 0.41 (0.32, 0.44) | 0.35 (0.24, 0.48) | NA (NA, NA) | 0.44 (0.41, 0.45) | NA (NA, NA) | 0.44 (0.44, 0.44) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC5 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC5 | rate | 0.131 (0.088, 0.236) | 0.187 (0.158, 0.217) | 0.147 (0.078, 0.263) | 0.123 (0.077, 0.254) | 0.044 (0.009, 0.08) | 0.198 (0.099, 0.385) | 0 (0, 0) | 0.238 (0.094, 0.625) | 0.168 (0.095, 0.275) | 0.298 (0.298, 0.298) | 0.275 (0.057, 3.804) | 0.276 (0.055, 0.497) | 0.073 (0, 0.29) | 1.358 (1.358, 1.358) | 0.834 (0.834, 0.834) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC1 | count | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | ||||||||||||||||
| TP53+ | TC1 | time | 20 (15, 33) | 20 (15, 33) | 20 (15, 33) | 20 (15, 33) | 20 (15, 33) | 20 (15, 33) | 20 (15, 33) | 20 (15, 33) | 20 (15, 33) | 20 (15, 33) | 20 (15, 33) | 20 (15, 33) | 20 (15, 33) | 20 (15, 33) | 20 (15, 33) | 20 (15, 33) | ||||||||||||||||
| TP53+ | TC1 | n | 8 (4, 13) | 6 (3, 12) | 2 (1, 4) | 5 (2, 9) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 1 (0, 2) | 0 (0, 1) | 0 (0, 0) | 6 (3, 10) | 3 (1, 7) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC1 | post_p | 0.35 (0.22, 0.46) | 0.38 (0.16, 0.49) | 0.42 (0.3, 0.49) | 0.34 (0.15, 0.46) | NA (NA, NA) | 0.43 (0.36, 0.49) | NA (NA, NA) | 0.44 (0.37, 0.5) | 0.42 (0.34, 0.48) | NA (NA, NA) | 0.36 (0.21, 0.48) | 0.35 (0.21, 0.45) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC1 | r_prob | 0.31 (0.31, 0.31) | 0.13 (0.13, 0.13) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC1 | rate | 0.159 (0.108, 0.245) | 0.165 (0.103, 0.27) | 0.208 (0.099, 1.057) | 0.168 (0.115, 0.469) | 0.086 (0.017, 0.155) | 0.144 (0.012, 0.576) | NA (NA, NA) | 0.147 (0.005, 2.408) | 0.124 (0, 0.851) | 0.352 (0.352, 0.352) | 0.151 (0.105, 0.302) | 0.201 (0.133, 0.865) | 0 (0, 0) | 0.989 (0.403, 1.576) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC2 | count | 41 | 41 | 41 | 41 | 41 | 41 | 41 | 41 | 41 | 41 | 41 | 41 | 41 | 41 | 41 | 41 | ||||||||||||||||
| TP53+ | TC2 | time | 21 (14, 30) | 21 (14, 30) | 21 (14, 30) | 21 (14, 30) | 21 (14, 30) | 21 (14, 30) | 21 (14, 30) | 21 (14, 30) | 21 (14, 30) | 21 (14, 30) | 21 (14, 30) | 21 (14, 30) | 21 (14, 30) | 21 (14, 30) | 21 (14, 30) | 21 (14, 30) | ||||||||||||||||
| TP53+ | TC2 | n | 6 (3, 12) | 5 (2, 10) | 3 (1, 5) | 4 (2, 10) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 1 (0, 2) | 0 (0, 2) | 0 (0, 0) | 6 (3, 11) | 4 (2, 10) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC2 | post_p | 0.37 (0.13, 0.49) | 0.32 (0.19, 0.45) | 0.38 (0.26, 0.47) | 0.38 (0.17, 0.47) | NA (NA, NA) | 0.43 (0.36, 0.48) | NA (NA, NA) | 0.46 (0.4, 0.5) | 0.44 (0.34, 0.48) | NA (NA, NA) | 0.38 (0.16, 0.48) | 0.38 (0.22, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC2 | r_prob | 0.17 (0.17, 0.17) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC2 | rate | 0.157 (0.111, 0.55) | 0.162 (0.103, 0.498) | 0.173 (0.116, 0.491) | 0.178 (0.112, 0.358) | NA (NA, NA) | 0.167 (0.052, 2.27) | 0.225 (0.107, 0.343) | 0.173 (0.005, 1.163) | 0.261 (0, 2.481) | 1.24 (1.24, 1.24) | 0.147 (0.106, 0.417) | 0.159 (0.108, 0.403) | 0.144 (0.029, 1.452) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC3 | count | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | ||||||||||||||||
| TP53+ | TC3 | time | 21 (17, 33) | 21 (17, 33) | 21 (17, 33) | 21 (17, 33) | 21 (17, 33) | 21 (17, 33) | 21 (17, 33) | 21 (17, 33) | 21 (17, 33) | 21 (17, 33) | 21 (17, 33) | 21 (17, 33) | 21 (17, 33) | 21 (17, 33) | 21 (17, 33) | 21 (17, 33) | ||||||||||||||||
| TP53+ | TC3 | n | 6 (3, 11) | 4 (2, 9) | 2 (1, 4) | 4 (2, 6) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 5 (3, 8) | 4 (1, 7) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC3 | post_p | 0.25 (0.16, 0.43) | 0.26 (0.15, 0.47) | 0.39 (0.32, 0.49) | 0.41 (0.27, 0.45) | NA (NA, NA) | 0.45 (0.44, 0.48) | NA (NA, NA) | 0.48 (0.41, 0.49) | 0.41 (0.38, 0.44) | NA (NA, NA) | 0.36 (0.21, 0.46) | 0.38 (0.27, 0.5) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC3 | r_prob | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TP53+ | TC3 | rate | 0.173 (0.12, 0.25) | 0.188 (0.125, 0.429) | 0.193 (0.011, 0.624) | 0.198 (0.109, 0.28) | 0 (0, 0) | 0.179 (0.039, 1.288) | NA (NA, NA) | 0.245 (0.038, 0.796) | 0.117 (0.045, 0.64) | 0.081 (0.081, 0.081) | 0.174 (0.138, 0.331) | 0.16 (0.116, 0.424) | 0 (0, 0.117) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC4 | count | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | ||||||||||||||||
| TP53+ | TC4 | time | 24 (19, 32) | 24 (19, 32) | 24 (19, 32) | 24 (19, 32) | 24 (19, 32) | 24 (19, 32) | 24 (19, 32) | 24 (19, 32) | 24 (19, 32) | 24 (19, 32) | 24 (19, 32) | 24 (19, 32) | 24 (19, 32) | 24 (19, 32) | 24 (19, 32) | 24 (19, 32) | ||||||||||||||||
| TP53+ | TC4 | n | 6 (4, 8) | 5 (3, 8) | 3 (1, 5) | 5 (2, 7) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 1 (0, 2) | 1 (0, 1) | 0 (0, 0) | 5 (3, 10) | 5 (2, 8) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC4 | post_p | 0.35 (0.25, 0.48) | 0.36 (0.14, 0.45) | 0.43 (0.25, 0.49) | 0.35 (0.21, 0.48) | NA (NA, NA) | 0.46 (0.41, 0.48) | NA (NA, NA) | 0.44 (0.42, 0.49) | 0.44 (0.42, 0.47) | NA (NA, NA) | 0.32 (0.12, 0.41) | 0.37 (0.21, 0.49) | 0.47 (0.47, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC4 | r_prob | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TP53+ | TC4 | rate | 0.142 (0.104, 0.206) | 0.211 (0.112, 0.636) | 0.178 (0.107, 0.36) | 0.203 (0.113, 0.321) | NA (NA, NA) | 0.088 (0.026, 0.229) | NA (NA, NA) | 0.077 (0, 0.284) | 0.232 (0, 0.618) | NA (NA, NA) | 0.185 (0.126, 0.364) | 0.157 (0.115, 0.26) | 0 (0, 0.131) | 0.193 (0.193, 0.193) | NA (NA, NA) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC5 | count | 38 | 38 | 38 | 38 | 38 | 38 | 38 | 38 | 38 | 38 | 38 | 38 | 38 | 38 | 38 | 38 | ||||||||||||||||
| TP53+ | TC5 | time | 24 (13, 32) | 24 (13, 32) | 24 (13, 32) | 24 (13, 32) | 24 (13, 32) | 24 (13, 32) | 24 (13, 32) | 24 (13, 32) | 24 (13, 32) | 24 (13, 32) | 24 (13, 32) | 24 (13, 32) | 24 (13, 32) | 24 (13, 32) | 24 (13, 32) | 24 (13, 32) | ||||||||||||||||
| TP53+ | TC5 | n | 6 (4, 11) | 6 (4, 12) | 1 (0, 3) | 6 (4, 11) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 2) | 0 (0, 1) | 0 (0, 0) | 4 (1, 8) | 5 (3, 9) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC5 | post_p | 0.36 (0.14, 0.47) | 0.35 (0.21, 0.46) | 0.4 (0.24, 0.45) | 0.33 (0.16, 0.47) | NA (NA, NA) | 0.44 (0.39, 0.49) | NA (NA, NA) | 0.45 (0.38, 0.5) | 0.48 (0.44, 0.49) | 0.5 (0.5, 0.5) | 0.34 (0.21, 0.47) | 0.42 (0.21, 0.49) | NA (NA, NA) | NA (NA, NA) | 0.43 (0.43, 0.43) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC5 | r_prob | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC5 | rate | 0.161 (0.109, 0.265) | 0.153 (0.119, 0.26) | 0.19 (0.111, 0.989) | 0.152 (0.119, 0.288) | NA (NA, NA) | 0.108 (0, 0.747) | 0.204 (0.204, 0.204) | 0.106 (0, 1.791) | 0.192 (0, 0.807) | 0.148 (0.03, 0.267) | 0.204 (0.128, 0.596) | 0.151 (0.092, 0.411) | 0.193 (0.193, 0.193) | 0.096 (0.096, 0.096) | 1.324 (1.25, 1.398) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC1 | count | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | ||||||||||||||||
| TEfus+ | TC1 | time | 22 (19, 32) | 22 (19, 32) | 22 (19, 32) | 22 (19, 32) | 22 (19, 32) | 22 (19, 32) | 22 (19, 32) | 22 (19, 32) | 22 (19, 32) | 22 (19, 32) | 22 (19, 32) | 22 (19, 32) | 22 (19, 32) | 22 (19, 32) | 22 (19, 32) | 22 (19, 32) | ||||||||||||||||
| TEfus+ | TC1 | n | 2 (0, 4) | 3 (1, 6) | 2 (1, 4) | 4 (2, 9) | 3 (0, 6) | 1 (0, 2) | 0 (0, 0) | 0 (0, 2) | 2 (0, 4) | 2 (1, 4) | 5 (4, 10) | 4 (1, 7) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC1 | post_p | 0.41 (0.33, 0.48) | 0.38 (0.28, 0.47) | 0.42 (0.33, 0.48) | 0.34 (0.26, 0.45) | 0.4 (0.2, 0.49) | 0.4 (0.32, 0.43) | NA (NA, NA) | 0.45 (0.36, 0.46) | 0.37 (0.24, 0.48) | 0.46 (0.37, 0.49) | 0.42 (0.3, 0.48) | 0.31 (0.2, 0.41) | 0.44 (0.44, 0.48) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC1 | r_prob | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC1 | rate | 0.2 (0.099, 1.139) | 0.195 (0.098, 2.167) | 0.158 (0.115, 0.488) | 0.157 (0.114, 0.321) | 0.119 (0.08, 0.44) | 0.289 (0.155, 0.6) | NA (NA, NA) | 0.193 (0.094, 3.404) | 0.192 (0.082, 0.549) | 0.139 (0.095, 0.493) | 0.125 (0.085, 0.2) | 0.212 (0.141, 1.061) | 0.407 (0, 2.385) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC2 | count | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | ||||||||||||||||
| TEfus+ | TC2 | time | 17 (14, 26) | 17 (14, 26) | 17 (14, 26) | 17 (14, 26) | 17 (14, 26) | 17 (14, 26) | 17 (14, 26) | 17 (14, 26) | 17 (14, 26) | 17 (14, 26) | 17 (14, 26) | 17 (14, 26) | 17 (14, 26) | 17 (14, 26) | 17 (14, 26) | 17 (14, 26) | ||||||||||||||||
| TEfus+ | TC2 | n | 1 (0, 2) | 2 (1, 5) | 2 (1, 5) | 4 (2, 7) | 3 (1, 5) | 0 (0, 2) | 0 (0, 0) | 0 (0, 1) | 2 (1, 5) | 1 (0, 3) | 6 (5, 11) | 6 (3, 8) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC2 | post_p | 0.42 (0.39, 0.5) | 0.43 (0.19, 0.48) | 0.41 (0.22, 0.46) | 0.43 (0.2, 0.49) | 0.38 (0.27, 0.48) | 0.32 (0.28, 0.34) | NA (NA, NA) | 0.42 (0.36, 0.43) | 0.43 (0.3, 0.45) | 0.44 (0.4, 0.48) | 0.38 (0.22, 0.5) | 0.4 (0.13, 0.48) | 0.4 (0.4, 0.4) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC2 | r_prob | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC2 | rate | 0.223 (0.01, 0.309) | 0.166 (0.098, 0.654) | 0.159 (0.095, 1.127) | 0.137 (0.086, 0.418) | 0.141 (0.051, 0.394) | 0.143 (0, 0.859) | 0.372 (0.372, 0.372) | 0.23 (0.071, 0.448) | 0.174 (0.121, 0.416) | 0.192 (0.124, 0.904) | 0.128 (0.087, 0.183) | 0.151 (0.103, 0.418) | 0.502 (0.048, 1.067) | 0 (0, 0) | NA (NA, NA) | 0.284 (0.284, 0.284) | ||||||||||||||||
| TEfus+ | TC3 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||
| TEfus+ | TC3 | time | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | ||||||||||||||||
| TEfus+ | TC3 | n | 3 (3, 3) | 1 (1, 1) | 0 (0, 0) | 3 (3, 3) | 4 (4, 4) | 3 (3, 3) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 5 (5, 5) | 4 (4, 4) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC3 | post_p | 0.35 (0.35, 0.35) | 0.35 (0.35, 0.35) | NA (NA, NA) | 0.32 (0.32, 0.32) | 0.5 (0.5, 0.5) | 0.49 (0.49, 0.49) | NA (NA, NA) | NA (NA, NA) | 0.4 (0.4, 0.4) | NA (NA, NA) | 0.44 (0.44, 0.44) | 0.34 (0.34, 0.34) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TEfus+ | TC3 | rate | 0.211 (0.211, 0.211) | 0.492 (0.492, 0.492) | NA (NA, NA) | 0.262 (0.262, 0.262) | 0.069 (0.069, 0.069) | 0.109 (0.109, 0.109) | NA (NA, NA) | NA (NA, NA) | 0.301 (0.301, 0.301) | NA (NA, NA) | 0.179 (0.179, 0.179) | 0.173 (0.173, 0.173) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC4 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||
| TEfus+ | TC4 | time | 25 (25, 25) | 25 (25, 25) | 25 (25, 25) | 25 (25, 25) | 25 (25, 25) | 25 (25, 25) | 25 (25, 25) | 25 (25, 25) | 25 (25, 25) | 25 (25, 25) | 25 (25, 25) | 25 (25, 25) | 25 (25, 25) | 25 (25, 25) | 25 (25, 25) | 25 (25, 25) | ||||||||||||||||
| TEfus+ | TC4 | n | 2 (2, 2) | 3 (3, 3) | 2 (2, 2) | 15 (15, 15) | 5 (5, 5) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 6 (6, 6) | 4 (4, 4) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC4 | post_p | 0.32 (0.32, 0.32) | 0.28 (0.28, 0.28) | 0.43 (0.43, 0.43) | 0.39 (0.39, 0.39) | 0.3 (0.3, 0.3) | 0.43 (0.43, 0.43) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.41 (0.41, 0.41) | 0.36 (0.36, 0.36) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TEfus+ | TC4 | rate | 0.54 (0.54, 0.54) | 0.232 (0.232, 0.232) | 0.148 (0.148, 0.148) | 0.123 (0.123, 0.123) | 0.111 (0.111, 0.111) | 0.102 (0.102, 0.102) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.159 (0.159, 0.159) | 0.217 (0.217, 0.217) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC5 | count | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | ||||||||||||||||
| TEfus+ | TC5 | time | 19 (12, 28) | 19 (12, 28) | 19 (12, 28) | 19 (12, 28) | 19 (12, 28) | 19 (12, 28) | 19 (12, 28) | 19 (12, 28) | 19 (12, 28) | 19 (12, 28) | 19 (12, 28) | 19 (12, 28) | 19 (12, 28) | 19 (12, 28) | 19 (12, 28) | 19 (12, 28) | ||||||||||||||||
| TEfus+ | TC5 | n | 1 (0, 4) | 4 (1, 7) | 1 (0, 4) | 6 (3, 9) | 3 (0, 5) | 1 (0, 3) | 0 (0, 0) | 1 (0, 2) | 2 (0, 4) | 2 (0, 3) | 4 (2, 6) | 5 (2, 9) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC5 | post_p | 0.41 (0.36, 0.49) | 0.39 (0.19, 0.45) | 0.41 (0.31, 0.49) | 0.31 (0.21, 0.46) | 0.33 (0.16, 0.42) | 0.4 (0.3, 0.45) | NA (NA, NA) | 0.45 (0.42, 0.46) | 0.38 (0.19, 0.45) | 0.44 (0.4, 0.48) | 0.36 (0.22, 0.47) | 0.38 (0.22, 0.45) | 0.46 (0.46, 0.46) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC5 | rate | 0.297 (0, 0.737) | 0.158 (0.109, 0.37) | 0.202 (0.087, 0.389) | 0.177 (0.118, 0.305) | 0.186 (0.077, 0.753) | 0.21 (0.155, 0.467) | NA (NA, NA) | 0.158 (0.092, 0.87) | 0.18 (0.091, 0.302) | 0.205 (0.08, 0.791) | 0.161 (0.121, 0.42) | 0.14 (0.089, 0.245) | 0.136 (0.034, 0.232) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC1 | count | 28 | 28 | 28 | 28 | 28 | 28 | 28 | 28 | 28 | 28 | 28 | 28 | 28 | 28 | 28 | 28 | ||||||||||||||||
| PI3K+ | TC1 | time | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | 24 (16, 32) | ||||||||||||||||
| PI3K+ | TC1 | n | 6 (3, 13) | 4 (1, 7) | 6 (3, 10) | 5 (2, 11) | 0 (0, 0) | 1 (0, 3) | 1 (0, 2) | 1 (0, 3) | 1 (0, 2) | 1 (0, 3) | 0 (0, 0) | 3 (1, 6) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC1 | post_p | 0.31 (0.18, 0.45) | 0.38 (0.23, 0.45) | 0.36 (0.19, 0.47) | 0.36 (0.17, 0.45) | NA (NA, NA) | 0.43 (0.33, 0.47) | 0.44 (0.41, 0.47) | 0.42 (0.36, 0.47) | 0.47 (0.36, 0.49) | 0.4 (0.27, 0.46) | NA (NA, NA) | 0.32 (0.18, 0.5) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC1 | r_prob | 0.22 (0.22, 0.22) | 0.22 (0.22, 0.22) | 0.13 (0.13, 0.13) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.14 (0.14, 0.14) | 0.14 (0.14, 0.14) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC1 | rate | 0.169 (0.112, 0.405) | 0.157 (0.097, 0.326) | 0.165 (0.107, 0.293) | 0.159 (0.108, 0.354) | 0.136 (0.136, 0.136) | 0.233 (0.089, 0.438) | 0.169 (0.057, 0.756) | 0.172 (0.024, 0.96) | 0.14 (0.031, 0.521) | 0.288 (0.016, 0.948) | 0.558 (0.558, 0.558) | 0.235 (0.112, 0.792) | NA (NA, NA) | 0 (0, 0) | 0.181 (0.181, 0.181) | 0.29 (0.29, 0.29) | ||||||||||||||||
| PI3K+ | TC2 | count | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | ||||||||||||||||
| PI3K+ | TC2 | time | 20 (17, 30) | 20 (17, 30) | 20 (17, 30) | 20 (17, 30) | 20 (17, 30) | 20 (17, 30) | 20 (17, 30) | 20 (17, 30) | 20 (17, 30) | 20 (17, 30) | 20 (17, 30) | 20 (17, 30) | 20 (17, 30) | 20 (17, 30) | 20 (17, 30) | 20 (17, 30) | ||||||||||||||||
| PI3K+ | TC2 | n | 6 (2, 11) | 3 (0, 7) | 7 (3, 10) | 4 (2, 9) | 0 (0, 0) | 1 (0, 4) | 1 (0, 3) | 0 (0, 2) | 1 (0, 2) | 1 (0, 2) | 0 (0, 0) | 4 (3, 8) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC2 | post_p | 0.38 (0.16, 0.49) | 0.37 (0.23, 0.44) | 0.33 (0.19, 0.42) | 0.34 (0.22, 0.41) | NA (NA, NA) | 0.38 (0.3, 0.46) | 0.42 (0.36, 0.47) | 0.44 (0.35, 0.5) | 0.42 (0.42, 0.46) | 0.45 (0.32, 0.49) | NA (NA, NA) | 0.34 (0.24, 0.46) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC2 | r_prob | 0.03 (0.03, 0.03) | 0.03 (0.03, 0.03) | 0.07 (0.07, 0.07) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.21 (0.21, 0.21) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC2 | rate | 0.163 (0.106, 0.258) | 0.175 (0.118, 0.373) | 0.168 (0.127, 0.355) | 0.152 (0.117, 0.34) | 0 (0, 0) | 0.159 (0.047, 0.558) | 0.22 (0.079, 0.632) | 0.23 (0.088, 0.469) | 0.193 (0, 0.514) | 0.17 (0.016, 0.358) | 0.62 (0.124, 1.116) | 0.148 (0.089, 0.248) | 0 (0, 0) | 0.373 (0.191, 0.556) | 0 (0, 0) | 0.584 (0.117, 1.052) | ||||||||||||||||
| PI3K+ | TC3 | count | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | ||||||||||||||||
| PI3K+ | TC3 | time | 18 (15, 26) | 18 (15, 26) | 18 (15, 26) | 18 (15, 26) | 18 (15, 26) | 18 (15, 26) | 18 (15, 26) | 18 (15, 26) | 18 (15, 26) | 18 (15, 26) | 18 (15, 26) | 18 (15, 26) | 18 (15, 26) | 18 (15, 26) | 18 (15, 26) | 18 (15, 26) | ||||||||||||||||
| PI3K+ | TC3 | n | 8 (5, 12) | 2 (2, 4) | 4 (2, 6) | 4 (2, 5) | 0 (0, 0) | 2 (1, 2) | 0 (0, 1) | 1 (1, 2) | 0 (0, 2) | 0 (0, 3) | 0 (0, 0) | 5 (2, 9) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC3 | post_p | 0.35 (0.2, 0.42) | 0.35 (0.19, 0.45) | 0.24 (0.12, 0.39) | 0.34 (0.25, 0.47) | NA (NA, NA) | 0.46 (0.46, 0.48) | 0.49 (0.49, 0.49) | 0.44 (0.4, 0.49) | 0.47 (0.45, 0.49) | 0.47 (0.47, 0.47) | NA (NA, NA) | 0.38 (0.26, 0.48) | 0.47 (0.47, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| PI3K+ | TC3 | rate | 0.16 (0.125, 0.238) | 0.304 (0.142, 0.669) | 0.211 (0.161, 0.897) | 0.188 (0.119, 0.306) | NA (NA, NA) | 0.062 (0, 0.769) | 0.032 (0, 0.387) | 0.159 (0.056, 0.33) | 0.199 (0.04, 0.261) | 0.289 (0.143, 0.514) | NA (NA, NA) | 0.169 (0.105, 0.262) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC4 | count | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | ||||||||||||||||
| PI3K+ | TC4 | time | 26 (22, 32) | 26 (22, 32) | 26 (22, 32) | 26 (22, 32) | 26 (22, 32) | 26 (22, 32) | 26 (22, 32) | 26 (22, 32) | 26 (22, 32) | 26 (22, 32) | 26 (22, 32) | 26 (22, 32) | 26 (22, 32) | 26 (22, 32) | 26 (22, 32) | 26 (22, 32) | ||||||||||||||||
| PI3K+ | TC4 | n | 7 (5, 22) | 4 (3, 8) | 6 (4, 10) | 5 (2, 10) | 0 (0, 0) | 1 (0, 2) | 0 (0, 1) | 1 (0, 1) | 1 (0, 1) | 0 (0, 1) | 0 (0, 0) | 3 (2, 7) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC4 | post_p | 0.34 (0.28, 0.44) | 0.34 (0.24, 0.44) | 0.38 (0.1, 0.45) | 0.4 (0.28, 0.45) | NA (NA, NA) | 0.43 (0.37, 0.48) | 0.44 (0.42, 0.46) | 0.44 (0.4, 0.48) | 0.44 (0.42, 0.44) | 0.45 (0.36, 0.49) | NA (NA, NA) | 0.4 (0.31, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| PI3K+ | TC4 | rate | 0.126 (0.114, 0.203) | 0.181 (0.122, 0.288) | 0.161 (0.128, 0.348) | 0.199 (0.12, 0.379) | NA (NA, NA) | 0.102 (0.069, 0.306) | 0.042 (0.008, 0.21) | 0.124 (0.014, 0.333) | 0.629 (0.492, 0.868) | 0.216 (0.143, 0.257) | NA (NA, NA) | 0.185 (0.13, 0.356) | NA (NA, NA) | 0 (0, 0) | 0.13 (0.079, 0.18) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC5 | count | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | ||||||||||||||||
| PI3K+ | TC5 | time | 20 (9, 30) | 20 (9, 30) | 20 (9, 30) | 20 (9, 30) | 20 (9, 30) | 20 (9, 30) | 20 (9, 30) | 20 (9, 30) | 20 (9, 30) | 20 (9, 30) | 20 (9, 30) | 20 (9, 30) | 20 (9, 30) | 20 (9, 30) | 20 (9, 30) | 20 (9, 30) | ||||||||||||||||
| PI3K+ | TC5 | n | 8 (4, 16) | 4 (2, 8) | 5 (3, 11) | 6 (2, 12) | 0 (0, 0) | 1 (0, 2) | 1 (0, 2) | 0 (0, 2) | 1 (0, 2) | 1 (0, 3) | 0 (0, 0) | 3 (2, 8) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC5 | post_p | 0.4 (0.17, 0.49) | 0.39 (0.18, 0.48) | 0.38 (0.17, 0.47) | 0.34 (0.2, 0.45) | NA (NA, NA) | 0.43 (0.31, 0.47) | 0.45 (0.37, 0.49) | 0.4 (0.28, 0.45) | 0.46 (0.43, 0.49) | 0.45 (0.32, 0.48) | NA (NA, NA) | 0.36 (0.22, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC5 | r_prob | 0.38 (0.38, 0.38) | 0.38 (0.38, 0.38) | 0.33 (0.33, 0.33) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC5 | rate | 0.139 (0.096, 0.292) | 0.162 (0.092, 0.394) | 0.153 (0.11, 0.327) | 0.17 (0.115, 0.375) | NA (NA, NA) | 0.249 (0.024, 2.254) | 0.173 (0, 0.386) | 0.198 (0.026, 0.88) | 0.121 (0, 0.367) | 0.168 (0, 0.828) | NA (NA, NA) | 0.195 (0.113, 0.7) | NA (NA, NA) | 0 (0, 0) | 0.096 (0.096, 0.096) | 0.191 (0.191, 0.191) |